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katdetectr

This is the development version of katdetectr; for the stable release version, see katdetectr.

All versions 3.24 (devel), 3.23 (release), 3.22, 3.21, 3.20, 3.19, 3.18, 3.17, 3.16

Detection, Characterization and Visualization of Kataegis in Sequencing Data


Bioconductor version: Development (3.24)

Kataegis refers to the occurrence of regional hypermutation and is a phenomenon observed in a wide range of malignancies. Using changepoint detection katdetectr aims to identify putative kataegis foci from common data-formats housing genomic variants. Katdetectr has shown to be a robust package for the detection, characterization and visualization of kataegis.

Author: Daan Hazelaar [aut, cre] ORCID iD ORCID: 0000-0002-7513-6813 , Job van Riet [aut] ORCID iD ORCID: 0000-0001-7767-7923 , Harmen van de Werken [ths] ORCID iD ORCID: 0000-0002-9794-1477

Maintainer: Daan Hazelaar <daanhazelaar at gmail.com>

Citation (from within R, enter citation("katdetectr")):

Daan Hazelaar, Job van Riet. katdetectr: Detection, Characterization and Visualization of Kataegis in Sequencing Data. doi:10.18129/B9.bioc.katdetectr, R package version 1.15.0, https://bioconductor.org/packages/katdetectr.

Generated from the package metadata; it may differ from the package's own citation.

Installation

To install this package, start R (version "4.6") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("katdetectr")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("katdetectr")
Overview_katdetectr HTML R Script
Reference ManualPDF
NEWSText
LICENSEText

Details

biocViews Classification, SNP, Sequencing, Software, VariantAnnotation, WholeGenome
Version1.15.0
In Bioconductor sinceBioC 3.16 (R-4.2) (4 years)
License GPL-3 + file LICENSE
Depends R (>= 4.2)
Imports Biobase (>= 2.54.0), BiocParallel (>= 1.26.2), BSgenome (>= 1.62.0), BSgenome.Hsapiens.UCSC.hg19 (>= 1.4.3), BSgenome.Hsapiens.UCSC.hg38 (>= 1.4.4), changepoint (>= 2.2.3), changepoint.np (>= 1.0.3), checkmate (>= 2.0.0), dplyr (>= 1.0.8), GenomeInfoDb (>= 1.28.4), GenomicRanges (>= 1.44.0), ggplot2 (>= 3.3.5), ggtext (>= 0.1.1), IRanges (>= 2.26.0), maftools (>= 2.10.5), methods (>= 4.1.3), plyranges (>= 1.17.0), Rdpack (>= 2.3.1), rlang (>= 1.0.2), S4Vectors (>= 0.30.2), scales (>= 1.2.0), tibble (>= 3.1.6), tidyr (>= 1.2.0), tools, utils, VariantAnnotation (>= 1.38.0)
System Requirements
URLhttps://doi.org/doi:10.18129/B9.bioc.katdetectr
Bug Reportshttps://github.com/ErasmusMC-CCBC/katdetectr/issues
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Suggests BiocStyle (>= 2.26.0), knitr (>= 1.37), rmarkdown (>= 2.13), stats, testthat (>= 3.0.0)
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package katdetectr_1.15.0.tar.gz
Windows Binary (x86_64) katdetectr_1.15.0.zip
macOS Binary (big-sur-x86_64) katdetectr_1.15.0.tgz
macOS Binary (sonoma-arm64) katdetectr_1.15.0.tgz
Source Repositorygit clone https://git.bioconductor.org/packages/katdetectr
Source Repository (Developer Access)git clone git@git.bioconductor.org:packages/katdetectr
Package Short Url https://bioconductor.org/packages/katdetectr/
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