immGLIPH

Grouping of Lymphocyte Interactions by Paratope Hotspots

Bioconductor version: 3.24 · Package version: 0.99.5

An R implementation of the GLIPH and GLIPH2 algorithms for clustering T cell receptors (TCRs) predicted to bind the same HLA-restricted peptide antigen. Identifies specificity groups based on local (motif-based) and global (sequence-based) CDR3 similarities. Integrates with the scRepertoire ecosystem via immApex for single-cell immune repertoire analysis. Users should cite the original GLIPH algorithm papers: Glanville et al. (2017) <doi:10.1038/nature22976> and Huang et al. (2020) <doi:10.1038/s41587-020-0505-4>.

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("immGLIPH")