a_high {RNAdecay} | R Documentation

## calculates bounds for modeled parameters

### Description

Calculates maximum and minimum bounds for parameter alpha based on experimental time points (t_0, t_1, t_2, t_3, ..., t_max). If RNA level is too low at t_1, then the decay has happened before our observations began - there is an upper bound to the decay rate we can detect (a_high). If RNA level is too high at t_max, then relatively little decay has happened and we can not distinguish the decay rate and the decay of the decay rate - there is a lower bound to the base decay rate of the decaying decay model (a_low).

### Usage

    a_high(t_min)

    a_low(t_max)

    b_low(t_max)

### Arguments

`t_min` | time of first experiemtal time point after inhibition of transcription (not T0)
`t_max` | time of last experimental time point

### Details

Similarly, limits on beta are required to prevent precude ranges in which the decay rate and decaing decay are indistinguishable. See vignette "RNAdecay_workflow" for more information.

### Value

returns the lowest/highest parameter values to be used as bounds on modeled parameters

### Examples

    a_high(7.5)
    a_low(480)
    b_low(480)

[Package RNAdecay version 1.3.1 Index]