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ceRNAnetsim

This is the development version of ceRNAnetsim; for the stable release version, see ceRNAnetsim.

All versions 3.24 (devel), 3.23 (release), 3.22, 3.21, 3.20, 3.19, 3.18, 3.17, 3.16, 3.15, 3.14, 3.13, 3.12, 3.11

Regulation Simulator of Interaction between miRNA and Competing RNAs (ceRNA)


Bioconductor version: Development (3.24)

This package simulates regulations of ceRNA (Competing Endogenous) expression levels after a expression level change in one or more miRNA/mRNAs. The methodolgy adopted by the package has potential to incorparate any ceRNA (circRNA, lincRNA, etc.) into miRNA:target interaction network. The package basically distributes miRNA expression over available ceRNAs where each ceRNA attracks miRNAs proportional to its amount. But, the package can utilize multiple parameters that modify miRNA effect on its target (seed type, binding energy, binding location, etc.). The functions handle the given dataset as graph object and the processes progress via edge and node variables.

Author: Selcen Ari Yuka [aut, cre] ORCID iD ORCID: 0000-0002-0028-2453 , Alper Yilmaz [aut] ORCID iD ORCID: 0000-0002-8827-4887

Maintainer: Selcen Ari Yuka <selcenarii at gmail.com>

Citation (from within R, enter citation("ceRNAnetsim")):

Selcen Ari Yuka, Alper Yilmaz. ceRNAnetsim: Regulation Simulator of Interaction between miRNA and Competing RNAs (ceRNA). doi:10.18129/B9.bioc.ceRNAnetsim, R package version 1.25.0, https://bioconductor.org/packages/ceRNAnetsim.

Generated from the package metadata; it may differ from the package's own citation.

Installation

To install this package, start R (version "4.6") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

## The following initializes the development version of Bioconductor
BiocManager::install(version = "devel")

BiocManager::install("ceRNAnetsim")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("ceRNAnetsim")
auxiliary_commands HTML R Script
basic_usage HTML R Script
A Suggestion: How to Find the Appropriate Iteration for Simulation HTML R Script
An TCGA dataset application HTML R Script
Reference ManualPDF
NEWSText

Details

biocViews GraphAndNetwork, Network, NetworkInference, Software, SystemsBiology, Transcriptomics
Version1.25.0
In Bioconductor sinceBioC 3.11 (R-4.0) (6.5 years)
License GPL (>= 3.0)
Depends R (>= 4.0.0), dplyr, tidygraph
Imports furrr, rlang, tibble, ggplot2, ggraph, igraph, purrr, tidyr, future, stats
System Requirements
URLhttps://github.com/selcenari/ceRNAnetsim
Bug Reportshttps://github.com/selcenari/ceRNAnetsim/issues
See More
Suggests knitr, png, rmarkdown, testthat, covr
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Build Report Build Report, r-universe

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package ceRNAnetsim_1.25.0.tar.gz
Windows Binary (x86_64) ceRNAnetsim_1.25.0.zip
macOS Binary (big-sur-x86_64) ceRNAnetsim_1.25.0.tgz
macOS Binary (sonoma-arm64) ceRNAnetsim_1.25.0.tgz
Source Repositorygit clone https://git.bioconductor.org/packages/ceRNAnetsim
Source Repository (Developer Access)git clone git@git.bioconductor.org:packages/ceRNAnetsim
Package Short Url https://bioconductor.org/packages/ceRNAnetsim/
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