format-version: 1.2
data-version: 1.5.1.10
date: 12:01:2010 15:21
saved-by: Ceri
auto-generated-by: OBO-Edit 2.0
default-namespace: cell
remark: $Revision: 1.44 $  Drafted by Jonathan Bard, Michael Ashburner, David States, Seung Y. Rhee, and Pascal Gaudet. Incorporating terms and synonyms from the eVOC cell ontology of Janet Kelso, Win Hide et al. http://www.sanbi.ac.za/evoc/ontologies.html. Hematopoietic cell terms revised by Alexander Diehl, MGI, The Jackson Laboratory. Contact Oliver Hofmann, oliver@sanbi.ac.za, at SANBI, University of the Western Cape.

[Term]
id: CL:0000000
name: cell
def: "Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah]
xref: FMA:68646

[Term]
id: CL:0000001
name: primary cell line cell
is_a: CL:0000010 ! cell line cell

[Term]
id: CL:0000002
name: permanent cell line cell
is_a: CL:0000010 ! cell line cell

[Term]
id: CL:0000003
name: cell in vivo
is_a: CL:0000000 ! cell

[Term]
id: CL:0000004
name: cell by organism
def: "A classification of cells by the organisms within which they are contained." [FB:ma]
is_a: CL:0000003 ! cell in vivo

[Term]
id: CL:0000005
name: fibroblast neural crest derived
is_a: CL:0000057 ! fibroblast
relationship: develops_from CL:0000008 ! cranial neural crest cell

[Term]
id: CL:0000006
name: receptor cell (sensu Animalia)
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000007
name: early embryonic cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000008
name: cranial neural crest cell
is_a: CL:0000333 ! neural crest cell

[Term]
id: CL:0000009
name: fusiform initial
alt_id: CL:0000274
def: "An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues." [ISBN:0471245208]
synonym: "xylem initial" RELATED []
synonym: "xylem mother cell" RELATED []
is_a: CL:0000272 ! cambial initial
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000010
name: cell line cell
is_a: CL:0000578 ! experimentally modified cell

[Term]
id: CL:0000011
name: trunk neural crest cell
is_a: CL:0000333 ! neural crest cell

[Term]
id: CL:0000012
name: cell by class
is_a: CL:0000003 ! cell in vivo

[Term]
id: CL:0000013
name: dentine secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000014
name: germ line stem cell
synonym: "germline stem cell" EXACT []
is_a: CL:0000034 ! stem cell
is_a: CL:0000039 ! germ line cell

[Term]
id: CL:0000015
name: male germ cell
is_a: CL:0000586 ! germ cell

[Term]
id: CL:0000016
name: male germ line stem cell
is_a: CL:0000014 ! germ line stem cell
is_a: CL:0000015 ! male germ cell

[Term]
id: CL:0000017
name: spermatocyte
def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [MESH:A.05.360.490.890.880]
xref: FBbt:00004936
is_a: CL:0000015 ! male germ cell

[Term]
id: CL:0000018
name: spermatid
def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [MESH:A.05.360.490.890.860]
xref: FBbt:00004942
is_a: CL:0000015 ! male germ cell

[Term]
id: CL:0000019
name: sperm
def: "A mature male germ cell that develops from a spermatid." [MESH:A.05.360.490.890]
synonym: "sperm cell" EXACT []
synonym: "spermatozoid" EXACT []
synonym: "spermatozoon" EXACT []
xref: FBbt:00004954
xref: FMA:67338
is_a: CL:0000015 ! male germ cell
is_a: CL:0000408 ! male gamete

[Term]
id: CL:0000020
name: spermatogonium
def: "An euploid male germ cell of an early stage of spermatogenesis." [MESH:A.05.360.490.890.900]
xref: FBbt:00004935
xref: FMA:72291
is_a: CL:0000015 ! male germ cell

[Term]
id: CL:0000021
name: female germ cell
is_a: CL:0000586 ! germ cell

[Term]
id: CL:0000022
name: female germ line stem cell
is_a: CL:0000014 ! germ line stem cell
is_a: CL:0000021 ! female germ cell

[Term]
id: CL:0000023
name: oocyte
xref: FBbt:00004886
xref: FMA:18644
is_a: CL:0000021 ! female germ cell

[Term]
id: CL:0000024
name: oogonial cell
is_a: CL:0000021 ! female germ cell

[Term]
id: CL:0000025
name: egg
synonym: "ovum" EXACT []
xref: FBbt:00000034
xref: FMA:67343
is_a: CL:0000675 ! female gamete

[Term]
id: CL:0000026
name: nurse cell
synonym: "nurse cell" RELATED []
xref: FBbt:00004878
is_a: CL:0000412 ! polyploid cell
is_a: CL:0000548 ! animal cell
relationship: develops_from CL:0000722 ! cystoblast

[Term]
id: CL:0000027
name: smooth muscle cell neural crest derived
is_a: CL:0000192 ! smooth muscle cell
relationship: develops_from CL:0000008 ! cranial neural crest cell

[Term]
id: CL:0000028
name: CNS neuron (sensu Nematoda and Protostomia)
is_a: CL:0000540 ! neuron
relationship: develops_from CL:0000338 ! neuroblast (sensu Nematoda and Protostomia)

[Term]
id: CL:0000029
name: neuron neural crest derived
is_a: CL:0000540 ! neuron
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0000030
name: glioblast
xref: FBbt:00005145
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000031
name: neuroblast
xref: FBbt:00005146
is_a: CL:0000047 ! neuronal stem cell
is_a: CL:0000055 ! non-terminally differentiated cell

[Term]
id: CL:0000032
name: neuroplacodal cell
is_a: CL:0000548 ! animal cell
relationship: develops_from CL:0000114 ! surface ectodermal cell

[Term]
id: CL:0000033
name: apocrine cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000034
name: stem cell
def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [MESH:A.11.872]
is_a: CL:0000012 ! cell by class

[Term]
id: CL:0000035
name: single fate stem cell
is_a: CL:0000723 ! somatic stem cell

[Term]
id: CL:0000036
name: epithelial fate stem cell
is_a: CL:0000035 ! single fate stem cell

[Term]
id: CL:0000037
name: hematopoietic stem cell
def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [GOC:add]
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hematopoietic progenitor cell" RELATED []
synonym: "hemopoietic progenitor cell" RELATED []
synonym: "hemopoietic stem cell" EXACT []
synonym: "HSC" EXACT []
is_a: CL:0000048 ! multi fate stem cell
relationship: develops_from CL:0000566 ! angioblastic mesenchymal cell

[Term]
id: CL:0000038
name: erythroid progenitor cell
def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464]
synonym: "BFU-E" RELATED []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "CFU-E" RELATED []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000050 ! megakaryocyte erythroid progenitor cell

[Term]
id: CL:0000039
name: germ line cell
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000040
name: monoblast
def: "A myeloid progenitor cell committed to the monocyte lineage." [GOC:add, http://www.clt.astate.edu/wwilliam/, http://www.copewithcytokines.de, PMID:1104740]
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
synonym: "CFU-M" RELATED []
synonym: "colony forming unit macrophage" RELATED []
synonym: "monocyte stem cell" RELATED []
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell

[Term]
id: CL:0000041
name: mature eosinophil
def: "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin." [GOC:add, ISBN:0721601464]
synonym: "mature eosinocyte" EXACT []
synonym: "mature eosinophil leucocyte" EXACT []
synonym: "mature eosinophil leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
is_a: CL:0000771 ! eosinophil
relationship: develops_from CL:0000772 ! immature eosinophil
relationship: develops_from CL:0000774 ! band form eosinophil

[Term]
id: CL:0000042
name: neutrophilic myeloblast
def: "A myeloblast committed to the neutrophil lineage. A myeloblast is the most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, and a nongranular basophilic cytoplasm." [GOC:add, ISBN:0721601464]
synonym: "neutrophilic granuloblast" RELATED []
is_a: CL:0000835 ! myeloblast
relationship: develops_from CL:0000834 ! neutrophil progenitor cell

[Term]
id: CL:0000043
name: mature basophil
alt_id: CL:0000739
def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [GOC:add, ISBN:0721601464]
synonym: "mature basophil leucocyte" EXACT []
synonym: "mature basophil leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
is_a: CL:0000767 ! basophil
relationship: develops_from CL:0000768 ! immature basophil
relationship: develops_from CL:0000770 ! band form basophil

[Term]
id: CL:0000045
name: thymus processed stem cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Consider using term 'pro-T cell ; CL:0000827' or the term 'thymocyte ; CL:0000893' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000046
name: bursa processed stem cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Consider using term 'pro-B cell ; CL:0000826' or the term 'immature B cell ; CL:0000816' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000047
name: neuronal stem cell
is_a: CL:0000048 ! multi fate stem cell
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000048
name: multi fate stem cell
def: "A stem cell that can give rise to mulitple lineages of cells." [GOC:add]
synonym: "multipotent stem cell" EXACT []
is_a: CL:0000723 ! somatic stem cell

[Term]
id: CL:0000049
name: common myeloid progenitor
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, PMID:10724173]
synonym: "cfu-gemm" RELATED [ISBN:0878932437]
synonym: "CFU-S" RELATED [ISBN:0878932437]
synonym: "CMP" EXACT [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437]
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000037 ! hematopoietic stem cell

[Term]
id: CL:0000050
name: megakaryocyte erythroid progenitor cell
def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add]
synonym: "CFU-EM" EXACT []
synonym: "colony forming unit erythroid megakaryocyte" EXACT []
synonym: "MEP" EXACT []
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000049 ! common myeloid progenitor

[Term]
id: CL:0000051
name: common lymphoid progenitor
alt_id: CL:0000044
def: "A progenitor cell committed to the lymphoid lineage with phenotype Lin-negative, CD117-low, Sca-1-low and CD127-positive." [GOC:add, PMID:10407577]
synonym: "CLP" EXACT []
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
synonym: "ELP" RELATED []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
is_a: CL:0000838 ! lymphoid progenitor cell
relationship: develops_from CL:0000936 ! early lymphoid progenitor

[Term]
id: CL:0000052
name: totipotent stem cell
def: "A stem cell from which all cells of the body can form." [GOC:add]
is_a: CL:0000723 ! somatic stem cell

[Term]
id: CL:0000053
name: enamel secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000054
name: bone matrix secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000055
name: non-terminally differentiated cell
def: "A precursor cell with a limited number of potential fates." [SANBI:mhl]
synonym: "blast cell" EXACT []
is_a: CL:0000012 ! cell by class

[Term]
id: CL:0000056
name: myoblast
def: "An embryonic (precursor) cell of the myogenic lineage that develops from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes." [MESH:A.11.635]
xref: FBbt:00005083
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000355 ! muscle stem cell

[Term]
id: CL:0000057
name: fibroblast
def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [MESH:A.11.329.228]
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000134 ! mesenchymal cell

[Term]
id: CL:0000058
name: chondroblast
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000548 ! animal cell
relationship: develops_from CL:0000134 ! mesenchymal cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000059
name: ameloblast
def: "A cylindrical epithelial cell in the innermost layer of the enamel organ. Their functions include contribution to the development of the dentinoenamel junction by the deposition of a layer of the matrix, thus producing the foundation for the prisms (the structural units of the dental enamel), and production of the matrix for the enamel prisms and interprismatic substance. (From Jablonski's Dictionary of Dentistry, 1992)." [MESH:A.11.436.107]
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000548 ! animal cell
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0000060
name: odontoblast
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000008 ! cranial neural crest cell

[Term]
id: CL:0000061
name: cementoblast
def: "A cell of ectomesenchymal origin concerned with the formation of the layer of cementum on the roots of teeth." [ISBN:0781733901 "Stedman's Medical Dictionary"]
is_a: CL:0000062 ! osteoblast

[Term]
id: CL:0000062
name: osteoblast
def: "A bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [MESH:A.11.329.629]
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000008 ! cranial neural crest cell
relationship: develops_from CL:0000375 ! osteoprogenitor cell

[Term]
id: CL:0000063
name: cell by histology
def: "A classification of cells by their microscopical appearance." [FB:ma]
is_a: CL:0000012 ! cell by class

[Term]
id: CL:0000064
name: ciliated cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000065
name: ependymal cell
def: "A neurectoderm derived cell that lines the neural lumen." [JB:jb, PMID:9550134]
synonym: "ependymocyte" EXACT []
is_a: CL:0000067 ! ciliated epithelial cell
relationship: develops_from CL:0000710 ! neuroepithelial cell

[Term]
id: CL:0000066
name: epithelial cell
def: "A cell that is usually found in a two-dimensional sheet with a free surface." [FB:ma, MESH:A.11.436]
xref: FBbt:00000124
is_a: CL:0000063 ! cell by histology

[Term]
id: CL:0000067
name: ciliated epithelial cell
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000068
name: duct epithelial cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000069
name: branched duct epithelial cell
is_a: CL:0000068 ! duct epithelial cell
relationship: develops_from CL:0000221 ! ectodermal cell
relationship: develops_from CL:0000222 ! mesodermal cell
relationship: develops_from CL:0000223 ! endodermal cell

[Term]
id: CL:0000070
name: epithelial cell of gland
is_obsolete: true

[Term]
id: CL:0000071
name: blood vessel endothelial cell
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000115 ! endothelial cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000072
name: non-branched duct epithelial cell
is_a: CL:0000068 ! duct epithelial cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000073
name: barrier epithelial cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000074
name: epithem cell
def: "A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap." [ISBN:0471245208, PMID:12662305]
is_a: CL:0000151 ! secretory cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000075
name: columnar/cuboidal epithelial cell
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0000076
name: squamous epithelial cell
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0000077
name: mesothelial cell
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000213 ! lining cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000078
name: peridermal cell
is_a: CL:0000076 ! squamous epithelial cell

[Term]
id: CL:0000079
name: stratified epithelial cell
is_a: CL:0000066 ! epithelial cell
relationship: develops_from CL:0000357 ! stratified epithelial stem cell

[Term]
id: CL:0000080
name: circulating cell
def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add]
is_a: CL:0000144 ! cell by function
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000081
name: blood cell
def: "A cell found predominately in the blood." [GOC:add]
is_a: CL:0000080 ! circulating cell
is_a: CL:0000988 ! hematopoietic cell

[Term]
id: CL:0000082
name: epithelial cell of lung
is_a: CL:0000066 ! epithelial cell
relationship: develops_from CL:0000223 ! endodermal cell

[Term]
id: CL:0000083
name: epithelial cell of pancreas
is_a: CL:0000066 ! epithelial cell
relationship: develops_from CL:0000223 ! endodermal cell

[Term]
id: CL:0000084
name: T cell
alt_id: CL:0000804
alt_id: CL:0000812
def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, ISBN:0781735149]
synonym: "immature T cell" RELATED []
synonym: "mature T cell" RELATED []
synonym: "T lymphocyte" EXACT []
synonym: "T-cell" EXACT []
synonym: "T-lymphocyte" EXACT []
is_a: CL:0000542 ! lymphocyte
relationship: develops_from CL:0000827 ! pro-T cell

[Term]
id: CL:0000085
name: germ line stem cell (sensu Vertebrata)
is_a: CL:0000014 ! germ line stem cell
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000086
name: germ line stem cell (sensu Nematoda and Protostomia)
xref: FBbt:00004861
is_a: CL:0000014 ! germ line stem cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000087
name: male germ line stem cell (sensu Nematoda and Protostomia)
xref: FBbt:00004929
is_a: CL:0000016 ! male germ line stem cell
is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000088
name: female germ line stem cell (sensu Nematoda and Protostomia)
xref: FBbt:00004873
is_a: CL:0000022 ! female germ line stem cell
is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000089
name: male germ line stem cell (sensu Vertebrata)
is_a: CL:0000016 ! male germ line stem cell
is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata)

[Term]
id: CL:0000090
name: female germ line stem cell (sensu Vertebrata)
is_a: CL:0000022 ! female germ line stem cell
is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata)

[Term]
id: CL:0000091
name: Kupffer cell
def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids." [GO_REF:0000031, GOC:add, MESH:A.11.329.372.588, PMID:15771589, PMID:17105582]
comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythro-cytes, iron metabolism.
is_a: CL:0000864 ! tissue-resident macrophage

[Term]
id: CL:0000092
name: osteoclast
def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158]
comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.
synonym: "chondroclast" RELATED []
is_a: CL:0000766 ! myeloid leukocyte
relationship: develops_from CL:0000576 ! monocyte

[Term]
id: CL:0000093
name: osteochondroclast
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Consider using 'osteoclast ; CL:0000092' instead.
is_obsolete: true

[Term]
id: CL:0000094
name: granulocyte
def: "A leukocyte with abundant granules in the cytoplasm." [MESH:A.11.118.637.415]
is_a: CL:0000766 ! myeloid leukocyte

[Term]
id: CL:0000095
name: neuron associated cell
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000096
name: mature neutrophil
def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [GOC:add, MESH:A.11.118.637.415.583]
synonym: "mature neutrocyte" EXACT []
synonym: "mature neutrophil leucocyte" EXACT []
synonym: "mature neutrophil leukocyte" EXACT []
synonym: "mature neutrophilic leucocyte" EXACT []
synonym: "mature neutrophilic leukocyte" EXACT []
synonym: "PMN" EXACT []
synonym: "poly" BROAD []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
synonym: "polymorphonuclear neutrophil" EXACT []
synonym: "polynuclear neutrophilic leucocyte" EXACT []
synonym: "polynuclear neutrophilic leukocyte" EXACT []
is_a: CL:0000775 ! neutrophil
relationship: develops_from CL:0000560 ! band form neutrophil
relationship: develops_from CL:0000776 ! immature neutrophil

[Term]
id: CL:0000097
name: mast cell
def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:add, ISBN:068340007X, MESH:A.11.329.427]
synonym: "labrocyte" EXACT [ISBN:0721601464]
synonym: "mastocyte" EXACT [ISBN:0721601464]
synonym: "tissue basophil" RELATED [ISBN:068340007X]
is_a: CL:0000766 ! myeloid leukocyte
relationship: develops_from CL:0000831 ! mast cell progenitor

[Term]
id: CL:0000098
name: sensory epithelial cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
relationship: develops_from CL:0000710 ! neuroepithelial cell

[Term]
id: CL:0000099
name: interneuron
def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [MESH:A.08.663.358]
xref: FBbt:00005125
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000100
name: motor neuron
def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [MESH:A.08.663.655.500, PMID:16875686]
synonym: "motoneuron" EXACT []
is_a: CL:0000527 ! efferent neuron

[Term]
id: CL:0000101
name: sensory neuron
xref: FBbt:00005124
is_a: CL:0000526 ! afferent neuron

[Term]
id: CL:0000102
name: polymodal neuron
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000103
name: bipolar neuron
def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." [ISBN:0444009442]
is_a: CL:0000063 ! cell by histology
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000104
name: multipolar neuron
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000105
name: pseudounipolar neuron
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000106
name: unipolar neuron
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000107
name: autonomic neuron
is_a: CL:0000029 ! neuron neural crest derived

[Term]
id: CL:0000108
name: cholinergic neuron
is_a: CL:0000107 ! autonomic neuron

[Term]
id: CL:0000109
name: adrenergic neuron
is_a: CL:0000107 ! autonomic neuron

[Term]
id: CL:0000110
name: peptidergic neuron
is_a: CL:0000107 ! autonomic neuron

[Term]
id: CL:0000111
name: peripheral neuron
is_a: CL:0000029 ! neuron neural crest derived

[Term]
id: CL:0000112
name: columnar neuron
synonym: "columnar neuron" RELATED []
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000113
name: mononuclear phagocyte
def: "A vertebrate phagocyte with a single nucleus." [GOC:add, ISBN:0781735149]
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)
is_a: CL:0000842 ! mononuclear cell

[Term]
id: CL:0000114
name: surface ectodermal cell
synonym: "cell of surface ectoderm" EXACT []
synonym: "surface ectoderm cell" EXACT []
xref: FMA:72552
is_a: CL:0000221 ! ectodermal cell

[Term]
id: CL:0000115
name: endothelial cell
is_a: CL:0000213 ! lining cell

[Term]
id: CL:0000116
name: pioneer neuron
xref: FBbt:00005128
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000117
name: CNS neuron (sensu Vertebrata)
is_a: CL:0000540 ! neuron
relationship: develops_from CL:0000337 ! neuroblast (sensu Vertebrata)

[Term]
id: CL:0000118
name: basket cell
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000119
name: Golgi cell
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000120
name: granule cell
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000121
name: Purkinje cell
def: "The output neuron of the cerebellar cortex." [MESH:A.08.186.211.132.810.428.200.212.600]
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
is_a: CL:0000527 ! efferent neuron

[Term]
id: CL:0000122
name: stellate cell
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000123
name: neuron associated cell (sensu Vertebrata)
relationship: develops_from CL:0000095 ! neuron associated cell
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0000124
name: glial cell (sensu Nematoda and Protostomia)
xref: FBbt:00005144
is_a: CL:0000125 ! glial cell
is_a: CL:0000340 ! glioblast (sensu Nematoda and Protostomia)

[Term]
id: CL:0000125
name: glial cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:A.08.637]
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
xref: FMA:54536
relationship: develops_from CL:0000030 ! glioblast
disjoint_from: CL:0000540

[Term]
id: CL:0000126
name: macroglial cell
is_a: CL:0000243 ! glial cell (sensu Vertebrata)
relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata)

[Term]
id: CL:0000127
name: astrocyte
def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [MESH:A.08.637.200]
xref: FMA:54537
is_a: CL:0000126 ! macroglial cell

[Term]
id: CL:0000128
name: oligodendrocyte
def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [MESH:A.08.637.600]
synonym: "oligodendroglia" RELATED []
xref: FMA:54540
is_a: CL:0000126 ! macroglial cell
relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata)

[Term]
id: CL:0000129
name: microglial cell
def: "A central nervous system macrophage found in the parenchyma of the central nervous system." [GOC:add, ISBN:0721601464]
comment: Markers: Mouse: CD11b+, F4/80+, CD68+.
synonym: "microglia" EXACT []
xref: FMA:54539
is_a: CL:0000878 ! central nervous system macrophage

[Term]
id: CL:0000130
name: neuron associated cell (sensu Nematoda and Protostomia)
is_a: CL:0000095 ! neuron associated cell

[Term]
id: CL:0000131
name: gut endothelial cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0000115 ! endothelial cell
relationship: develops_from CL:0000223 ! endodermal cell

[Term]
id: CL:0000132
name: corneal endothelial cell
def: "Cell of the single layer of large flattened cells covering the surface of the cornea." [MESH:A.09.371.060.067.31]
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000115 ! endothelial cell
relationship: develops_from CL:0000008 ! cranial neural crest cell

[Term]
id: CL:0000133
name: neurectodermal cell
synonym: "neurectoderm cell" EXACT []
is_a: CL:0000221 ! ectodermal cell

[Term]
id: CL:0000134
name: mesenchymal cell
def: "A cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [FB:ma]
is_a: CL:0000063 ! cell by histology
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000135
name: fibrocyte
xref: FMA:63879
is_a: CL:0000499 ! stromal cell
relationship: develops_from CL:0000005 ! fibroblast neural crest derived
relationship: develops_from CL:0000057 ! fibroblast

[Term]
id: CL:0000136
name: fat cell
def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:A.11.329.114]
synonym: "adipocyte" EXACT []
synonym: "lipocyte" EXACT []
is_a: CL:0000325 ! stuff accumulating cell
relationship: develops_from CL:0000057 ! fibroblast
relationship: develops_from CL:0000134 ! mesenchymal cell

[Term]
id: CL:0000137
name: osteocyte
def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." [MESH:A.11.329.629.500]
is_a: CL:0000054 ! bone matrix secreting cell
relationship: develops_from CL:0000062 ! osteoblast

[Term]
id: CL:0000138
name: chondrocyte
def: "Polymorphic cell that form cartilage." [MESH:A.11.329.171]
is_a: CL:0000153 ! GAG secreting cell
is_a: CL:0000667 ! collagen secreting cell
relationship: develops_from CL:0000058 ! chondroblast

[Term]
id: CL:0000139
name: amelocyte
is_a: CL:0000053 ! enamel secreting cell
is_a: CL:0000146 ! simple columnar epithelial cell
relationship: develops_from CL:0000059 ! ameloblast

[Term]
id: CL:0000140
name: odontocyte
is_a: CL:0000013 ! dentine secreting cell
relationship: develops_from CL:0000060 ! odontoblast
relationship: develops_from CL:0000134 ! mesenchymal cell

[Term]
id: CL:0000141
name: cementocyte
def: "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth." [ISBN:0781733901 "Stedman's Medical Dictionary"]
is_a: CL:0000137 ! osteocyte
relationship: develops_from CL:0000061 ! cementoblast

[Term]
id: CL:0000142
name: hyalocyte
is_a: CL:0000499 ! stromal cell

[Term]
id: CL:0000143
name: guidepost cell
is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000144
name: cell by function
def: "A classification of cells by their primary end goal or behavior." [FB:ma]
is_a: CL:0000012 ! cell by class

[Term]
id: CL:0000145
name: professional antigen presenting cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149]
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constituitively express MHC Class II as well as constimulatory molecules, and thus can initiate immune responses via T cells.
synonym: "APC" BROAD []
is_a: CL:0000473 ! defensive cell

[Term]
id: CL:0000146
name: simple columnar epithelial cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000147
name: pigment cell
synonym: "chromatocyte" RELATED []
synonym: "chromatophore" RELATED []
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000148
name: melanocyte
alt_id: CL:0000572
def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." [SANBI:mhl]
synonym: "melanophore" NARROW []
xref: FMA:70545
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0000541 ! melanoblast

[Term]
id: CL:0000149
name: visual pigment cell
synonym: "pigment cell" BROAD []
is_a: CL:0000147 ! pigment cell

[Term]
id: CL:0000150
name: glandular epithelial cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000151
name: secretory cell
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000152
name: exocrine cell
def: "A cell of an exocrine gland, i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684]
xref: FMA:16014
is_a: CL:0000151 ! secretory cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000153
name: GAG secreting cell
synonym: "hyaluronic acid secreting cell" EXACT []
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000154
name: protein secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000155
name: pepsinogen secreting cell
synonym: "chief cell" RELATED []
synonym: "peptic cell" EXACT []
synonym: "zymogenic cell" EXACT []
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000156
name: antibody secreting cell
def: "OBSOLETE: A cell of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B cells, can be defined, based on the different classes of immunoglobulins that they synthesize." []
comment: Consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000157
name: surfactant secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000158
name: Clara cell
def: "Epithelial progenitor cell of the lung. Clara cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium." [PMID:12107102, PMID:7905712]
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000159
name: seromucus secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000160
name: goblet cell
def: "A cell of the epithelial lining that produce and secrete mucins." [MESH:A.03.492.411.369.320]
synonym: "chalice cell" EXACT []
xref: FMA:13148
is_a: CL:0000319 ! mucus secreting cell

[Term]
id: CL:0000161
name: acid secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000162
name: parietal cell
synonym: "oxyntic cell" EXACT []
xref: FMA:62901
is_a: CL:0000161 ! acid secreting cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000163
name: endocrine cell
def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:A.06.407]
is_a: CL:0000151 ! secretory cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000164
name: enteroendocrine cell
def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract." [SANBI:mhl]
xref: FMA:62930
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000165
name: neuroendocrine cell
def: "A neuron that has the specialized function to produce and secrete hormones, and that constitutes, in whole or in part, an endocrine organ or system." [MESH:A.06.688]
synonym: "neurosecretory cell" EXACT []
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000393 ! electrically responsive cell

[Term]
id: CL:0000166
name: chromaffin cell
def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:A.06.224.161]
synonym: "phaeochromocyte" EXACT []
xref: FMA:69263
is_a: CL:0000165 ! neuroendocrine cell
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0000167
name: peptide hormone secreting cell
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000168
name: insulin secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000169
name: pancreatic B cell
synonym: "pancreatic beta cell" EXACT []
xref: FMA:70586
is_a: CL:0000168 ! insulin secreting cell

[Term]
id: CL:0000170
name: glucagon secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000171
name: pancreatic A cell
synonym: "pancreatic alpha cell" EXACT []
xref: FMA:70585
is_a: CL:0000170 ! glucagon secreting cell

[Term]
id: CL:0000172
name: somatostatin secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000173
name: pancreatic D cell
synonym: "pancreatic delta cell" EXACT []
xref: FMA:70587
is_a: CL:0000502 ! D cell

[Term]
id: CL:0000174
name: steroid hormone secreting cell
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000175
name: luteal cell
def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." [MESH:A.05.360.319.114.630.278.400]
synonym: "lutein cell" EXACT []
xref: FMA:18688
is_a: CL:0000174 ! steroid hormone secreting cell

[Term]
id: CL:0000176
name: ecdysteroid secreting cell
is_a: CL:0000174 ! steroid hormone secreting cell

[Term]
id: CL:0000177
name: testosterone secreting cell
is_a: CL:0000174 ! steroid hormone secreting cell

[Term]
id: CL:0000178
name: Leydig cell
synonym: "interstitial cell" EXACT []
xref: FMA:72297
is_a: CL:0000177 ! testosterone secreting cell

[Term]
id: CL:0000179
name: progesterone secreting cell
is_a: CL:0000174 ! steroid hormone secreting cell

[Term]
id: CL:0000180
name: estradiol secreting cell
is_a: CL:0000174 ! steroid hormone secreting cell

[Term]
id: CL:0000181
name: metabolising cell
def: "A cell whose primary function is intermediary metabolism." [FB:ma]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000182
name: hepatocyte
def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules." [MESH:A.11.436.348]
xref: FMA:14515
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000181 ! metabolising cell
is_a: CL:0000417 ! endopolyploid cell
is_a: CL:0000548 ! animal cell
relationship: develops_from CL:0000134 ! mesenchymal cell
relationship: develops_from CL:0000223 ! endodermal cell

[Term]
id: CL:0000183
name: contractile cell
def: "A cell whose primary function is to shorten." [FB:ma]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000184
name: pericyte
def: "A slender, contractile, mesenchymal-like cell found in close association with capillary walls. They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. (From Stedman, 26th ed)." [MESH:A.07.231.330.600]
is_a: CL:0000183 ! contractile cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000185
name: myoepithelial cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0000183 ! contractile cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000186
name: myofibroblast cell
is_a: CL:0000183 ! contractile cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000187
name: muscle cell
def: "A mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [MESH:A.11.620]
synonym: "myocyte" EXACT []
xref: FBbt:00005074
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
relationship: develops_from CL:0000056 ! myoblast

[Term]
id: CL:0000188
name: skeletal muscle cell
synonym: "striated muscle cell" EXACT []
is_a: CL:0000187 ! muscle cell
is_a: CL:0000228 ! multinucleate cell
relationship: develops_from CL:0000515 ! skeletal muscle myoblast

[Term]
id: CL:0000189
name: slow muscle cell
synonym: "red muscle cell" EXACT []
synonym: "slow muscle fiber" EXACT [ISBN:0815316208]
is_a: CL:0000188 ! skeletal muscle cell
relationship: develops_from CL:0000857 ! slow muscle myoblast

[Term]
id: CL:0000190
name: fast muscle cell
synonym: "white muscle cell" EXACT []
is_a: CL:0000188 ! skeletal muscle cell
relationship: develops_from CL:0000858 ! fast muscle myoblast

[Term]
id: CL:0000192
name: smooth muscle cell
alt_id: CL:0000191
def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [MESH:A.11.620.520]
synonym: "non-striated muscle cell" EXACT []
xref: FMA:14072
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0000193
name: cardiac muscle cell (sensu Arthopoda)
alt_id: CL:0000466
def: "A striated muscle cell found in the heart. They develop from cardiac myoblasts." [MESH:A.11.620.500]
synonym: "cardiocyte" EXACT []
synonym: "heart muscle cell" EXACT []
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000746 ! cardiac muscle cell
relationship: develops_from CL:0000465 ! cardioblast (sensu Arthropoda)

[Term]
id: CL:0000194
name: nodal cardiac cell
is_obsolete: true

[Term]
id: CL:0000195
name: Purkinje fiber
is_obsolete: true

[Term]
id: CL:0000196
name: flight muscle cell
is_a: CL:0000187 ! muscle cell
is_a: CL:0000228 ! multinucleate cell

[Term]
id: CL:0000197
name: receptor cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000198
name: pain receptor cell
def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:A.08.800.550.700.650]
synonym: "nociceptor" EXACT []
synonym: "nocireceptor" EXACT []
is_a: CL:0000006 ! receptor cell (sensu Animalia)

[Term]
id: CL:0000199
name: mechanoreceptor cell
def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [MESH:A.08.800.550.700.500]
is_a: CL:0000006 ! receptor cell (sensu Animalia)

[Term]
id: CL:0000200
name: touch receptor cell
is_a: CL:0000199 ! mechanoreceptor cell

[Term]
id: CL:0000201
name: auditory receptor cell
is_a: CL:0000006 ! receptor cell (sensu Animalia)

[Term]
id: CL:0000202
name: auditory hair cell
def: "A mechanoreceptor cell located in the inner ear that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [MESH:A.08.663.650.250]
comment: In mammals these cells are located in the organ of Corti.
synonym: "cochlear hair cell" EXACT []
xref: FMA:62364
is_a: CL:0000201 ! auditory receptor cell
is_a: CL:0000855 ! hair cell

[Term]
id: CL:0000203
name: gravity sensitive cell
is_a: CL:0000006 ! receptor cell (sensu Animalia)

[Term]
id: CL:0000204
name: acceleration receptive cell
is_a: CL:0000006 ! receptor cell (sensu Animalia)

[Term]
id: CL:0000205
name: thermoreceptor cell
def: "A cellular receptor which mediates the sense of temperature. Thermoreceptors in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." [MESH:A.08.800.550.700.840]
is_a: CL:0000006 ! receptor cell (sensu Animalia)

[Term]
id: CL:0000206
name: chemoreceptor cell
def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:A.08.800.550.700.120]
is_a: CL:0000006 ! receptor cell (sensu Animalia)

[Term]
id: CL:0000207
name: olfactory receptor cell
synonym: "olfactory receptor neuron" EXACT []
synonym: "olfactory sensory neuron" EXACT []
synonym: "Schultze's cell" EXACT []
xref: FMA:67860
is_a: CL:0000206 ! chemoreceptor cell

[Term]
id: CL:0000208
name: pH receptor cell
is_a: CL:0000206 ! chemoreceptor cell

[Term]
id: CL:0000209
name: taste receptor cell
is_a: CL:0000206 ! chemoreceptor cell

[Term]
id: CL:0000210
name: photoreceptor cell
def: "A cell specialized to detect and transduce light." [MESH:A.08.663.650.650]
xref: FBbt:00004211
is_a: CL:0000006 ! receptor cell (sensu Animalia)

[Term]
id: CL:0000211
name: electrically active cell
def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma]
is_a: CL:0000144 ! cell by function
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000212
name: absorptive cell
def: "A cell that takes up and metabolizes substances." [CL:CVS]
is_a: CL:0000144 ! cell by function
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000213
name: lining cell
def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb]
synonym: "boundary cell" EXACT []
is_a: CL:0000215 ! barrier cell

[Term]
id: CL:0000214
name: synovial cell
is_a: CL:0000153 ! GAG secreting cell
is_a: CL:0000213 ! lining cell
relationship: develops_from CL:0000134 ! mesenchymal cell

[Term]
id: CL:0000215
name: barrier cell
def: "A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb]
is_a: CL:0000144 ! cell by function
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000216
name: Sertoli cell
def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:A.05.360.444.849.789]
is_a: CL:0000215 ! barrier cell
is_a: CL:0000511 ! androgen binding protein secreting cell

[Term]
id: CL:0000217
name: insulating cell
is_a: CL:0000215 ! barrier cell

[Term]
id: CL:0000218
name: Schwann cell
def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [MESH:A.08.637.800]
is_a: CL:0000217 ! insulating cell
is_a: CL:0000243 ! glial cell (sensu Vertebrata)
is_a: CL:0000328 ! myelin accumulating cell

[Term]
id: CL:0000219
name: motile cell
def: "A cell that moves by its own activities." [FB:ma]
is_a: CL:0000144 ! cell by function
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000220
name: cell by lineage
is_a: CL:0000012 ! cell by class

[Term]
id: CL:0000221
name: ectodermal cell
def: "A cell of the outer of the three germ layers of the embryo." [MESH:A.16.254.425.273]
synonym: "ectoderm cell" EXACT []
is_a: CL:0000220 ! cell by lineage
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000222
name: mesodermal cell
def: "A cell of the middle germ layer of the embryo." [MESH:A.16.254.425.660]
synonym: "mesoblast" EXACT []
synonym: "mesoderm cell" EXACT []
is_a: CL:0000220 ! cell by lineage
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000223
name: endodermal cell
def: "A cell of the inner of the three germ layers of the embryo." [MESH:A.16.254.425.407]
synonym: "endoderm cell" EXACT []
is_a: CL:0000220 ! cell by lineage
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000224
name: cell by nuclear number
def: "A classification of cells by the number of their nuclei." [FB:ma]
is_a: CL:0000012 ! cell by class

[Term]
id: CL:0000225
name: anucleate cell
def: "A cell that lacks a nucleus." [FB:ma]
is_a: CL:0000224 ! cell by nuclear number

[Term]
id: CL:0000226
name: single nucleate cell
def: "A cell with a single nucleus." [FB:ma]
is_a: CL:0000224 ! cell by nuclear number

[Term]
id: CL:0000227
name: binucleate cell
is_a: CL:0000228 ! multinucleate cell

[Term]
id: CL:0000228
name: multinucleate cell
def: "A cell with more than one nucleus." [FB:ma]
synonym: "syncitium" EXACT []
synonym: "syncytial cell" EXACT []
synonym: "syncytium" EXACT []
is_a: CL:0000224 ! cell by nuclear number

[Term]
id: CL:0000229
name: lymphoblast
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Refers to an activated mature lymphocyte phenotype rather than a distinct cell type; consider using 'lymphocyte ; CL:0000542' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000230
name: T lymphoblast
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Refers to an activated mature T lymphocyte phenotype rather than a distinct cell type; consider using 'T cell ; CL:0000084' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000231
name: B lymphoblast
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Refers to an activated mature B lymphocyte phenotype rather than a distinct cell type; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000232
name: erythrocyte
def: "A red blood cell. In mammals, mature erythrocytes are non-nucleated, biconcave disks containing hemoglobin whose function is to transport oxygen." [MESH:A.11.118.290]
synonym: "RBC" EXACT []
synonym: "red blood cell" EXACT []
xref: FMA:62845
is_a: CL:0000081 ! blood cell
is_a: CL:0000329 ! oxygen accumulating cell
is_a: CL:0000764 ! erythroid lineage cell
relationship: develops_from CL:0000558 ! reticulocyte

[Term]
id: CL:0000233
name: platelet
def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [GOC:add, MESH:A.11.118.188]
synonym: "blood platelet" EXACT []
synonym: "thrombocyte" RELATED []
is_a: CL:0000081 ! blood cell
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000763 ! myeloid cell
relationship: develops_from CL:0000556 ! megakaryocyte

[Term]
id: CL:0000234
name: phagocyte
def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464]
is_a: CL:0000219 ! motile cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000473 ! defensive cell

[Term]
id: CL:0000235
name: macrophage
def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, http://www.clt.astate.edu/wwilliam/]
comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
synonym: "histiocyte" EXACT []
is_a: CL:0000766 ! myeloid leukocyte
relationship: develops_from CL:0000576 ! monocyte

[Term]
id: CL:0000236
name: B cell
def: "A lymphocyte of B lineage with the phenotype CD19-positive and surface immunoglobulin-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149]
synonym: "B lymphocyte" EXACT []
synonym: "B-cell" EXACT []
synonym: "B-lymphocyte" EXACT []
is_a: CL:0000945 ! lymphocyte of B lineage
relationship: develops_from CL:0000826 ! pro-B cell

[Term]
id: CL:0000237
name: keratinizing barrier epithelial cell
is_a: CL:0000240 ! stratified squamous epithelial cell
is_a: CL:0000311 ! keratin accumulating cell
relationship: develops_from CL:0000114 ! surface ectodermal cell

[Term]
id: CL:0000238
name: non keratinizing barrier epithelial cell
is_a: CL:0000240 ! stratified squamous epithelial cell

[Term]
id: CL:0000239
name: brush border epithelial cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000240
name: stratified squamous epithelial cell
is_a: CL:0000079 ! stratified epithelial cell

[Term]
id: CL:0000241
name: stratified cuboidal epithelial cell
is_a: CL:0000079 ! stratified epithelial cell

[Term]
id: CL:0000242
name: Merkel cell
def: "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." [MESH:A.08.800.550.700.500.425]
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)

[Term]
id: CL:0000243
name: glial cell (sensu Vertebrata)
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." [MESH:A.08.637]
is_a: CL:0000125 ! glial cell
relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata)

[Term]
id: CL:0000244
name: transitional epithelial cell
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0000245
name: passage cell
def: "Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." [ISBN:0471245208]
is_a: CL:0000293 ! structural cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000246
name: Mauthner neuron
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000247
name: Rohon-Beard neuron
is_a: CL:0000531 ! primary sensory neuron

[Term]
id: CL:0000248
name: microsporocyte
def: "A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [ISBN:0471245208]
synonym: "pollen mother cell" EXACT []
synonym: "primary sporogenous cell" EXACT []
is_a: CL:0000039 ! germ line cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000249
name: hatching gland cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000250
name: megaspore
def: "A haploid (1n) spore developing into a female gametophyte in heterosporous plants." [ISBN:0471245208]
is_a: CL:0000021 ! female germ cell
relationship: develops_from CL:0000320 ! megasporocyte

[Term]
id: CL:0000251
name: extramedullary cell
is_a: CL:0000101 ! sensory neuron

[Term]
id: CL:0000252
name: microspore
def: "A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants." [ISBN:0471245208]
synonym: "pollen" RELATED []
is_a: CL:0000015 ! male germ cell
relationship: develops_from CL:0000248 ! microsporocyte

[Term]
id: CL:0000253
name: eurydendroid cell
is_a: CL:0000527 ! efferent neuron

[Term]
id: CL:0000254
name: egg cell
def: "The female gamete of plants." [TAIR:lr]
synonym: "female gametophyte egg cell" EXACT []
is_a: CL:0000610 ! plant cell
is_a: CL:0000675 ! female gamete

[Term]
id: CL:0000255
name: eukaryotic cell
is_a: CL:0000004 ! cell by organism
disjoint_from: CL:0000520 ! prokaryotic cell

[Term]
id: CL:0000256
name: uric acid accumulating cell
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000257
name: Mycetozoan cell
is_a: CL:0000255 ! eukaryotic cell

[Term]
id: CL:0000258
name: fiber tracheid
def: "A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures." [ISBN:0471245208]
is_a: CL:0000672 ! tracheary element

[Term]
id: CL:0000259
name: aggregate cell
def: "Differentiating cell composing the aggregate that has acquired adhesive properties." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000260
name: mucilage cell
def: "Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water." [ISBN:0471245208]
is_a: CL:0000151 ! secretory cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000261
name: anterior cell
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000262
name: guard mother cell
def: "An epidermal cell that divides to produce the guard cells." [ISBN:0471245208]
is_a: CL:0000362 ! epidermal cell
is_a: CL:0000610 ! plant cell
relationship: develops_from CL:0000538 ! epidermal initial

[Term]
id: CL:0000263
name: vegetative cell (sensu Mycetozoa)
def: "Unicellular haploid myxamoebae that feeds on bacteria and divides by binary fission." [DictyBase:DDB]
synonym: "amoeba" EXACT []
is_a: CL:0000257 ! Mycetozoan cell

[Term]
id: CL:0000264
name: phloem initial
def: "A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes." [ISBN:0471245208]
synonym: "phloem mother cell" EXACT []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000272 ! cambial initial

[Term]
id: CL:0000265
name: anterior like cell
def: "Cell that has properties of anterior cells (for e.g., accumulate vital dyes in autophagic vesicles) but that is are scattered throughout the rear of the slug. Some but not all these cells express the ecmA gene and/or the ecmB gene. ALCs maintain an amoeboid appearance during culmination. ALCs that express the ecmO promoter have been called pstO/ALC." [DictyBase:DDB]
synonym: "ALC" EXACT []
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000266
name: meristemoid
def: "A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells." [ISBN:0471245208]
is_a: CL:0000610 ! plant cell
is_a: CL:0000723 ! somatic stem cell

[Term]
id: CL:0000267
name: prespore cell
def: "Cell that is undergoing differentiation to become a spore." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000268
name: sieve element
def: "The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member." [ISBN:0471245208]
is_a: CL:0000610 ! plant cell
is_a: CL:0000627 ! transporting cell

[Term]
id: CL:0000269
name: prestalk cell
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000270
name: subsidiary cell
def: "An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue." [ISBN:047124520]
synonym: "accessory cell" RELATED []
xref: TAIR:0000296
is_a: CL:0000293 ! structural cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000271
name: prestalk A cell
def: "Cell expressing the ecmA marker from a promoter region that is proximal to the ATG (ecmAO promoter). They are located at the anterior-most region of the slug. During culmination pstA cells differentiate into pstAB cells." [DictyBase:DDB]
synonym: "pstA" EXACT []
synonym: "pstAO" EXACT []
is_a: CL:0000269 ! prestalk cell

[Term]
id: CL:0000272
name: cambial initial
def: "A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells)." [ISBN:0471245208]
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000685 ! meristematic cell

[Term]
id: CL:0000273
name: prestalk AB cell
def: "Cell that expresses both ecmA and ecmB either simultaneously or sequentially. During culmination pstA differentiate into pstAB cells." [DictyBase:DDB]
synonym: "pstAB" EXACT []
is_a: CL:0000269 ! prestalk cell

[Term]
id: CL:0000275
name: prestalk B cell
def: "Cell expressing ecmB but not ecmA. Most pstB cells are located at the very rear of the slug (rearguard region). These cells form part of the basal disc of the fruiting body. If a migratory slug is formed, these cells are left behind." [DictyBase:DDB]
synonym: "pstB" EXACT []
is_a: CL:0000269 ! prestalk cell

[Term]
id: CL:0000276
name: sclerenchyma cell
def: "Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity." [ISBN:0471245208]
is_a: CL:0000293 ! structural cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000277
name: prestalk I cell
def: "Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." [DictyBase:DDB]
is_a: CL:0000269 ! prestalk cell

[Term]
id: CL:0000278
name: central cell
def: "A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm." [TAIR:lr]
is_a: CL:0000021 ! female germ cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000279
name: prestalk 0 cell
def: "Cell that express ecmA at a very low level. Located at the posterior half of the prestalk zone. Expresses ecmA from the distal region of its promoter (ecmO)." [DictyBase:DDB]
is_a: CL:0000269 ! prestalk cell

[Term]
id: CL:0000280
name: generative cell
def: "The cell that will give rise to the generative nuclei which will participate in fertilization." [TAIR:lr]
is_a: CL:0000039 ! germ line cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000281
name: pstAB/ALC
def: "Anterior-like cell expressing both ecmA and ecmB." [DictyBase:DDB]
is_a: CL:0000265 ! anterior like cell

[Term]
id: CL:0000282
name: trichome
def: "An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata." [ISBN:0471245208, PMID:10938806]
is_a: CL:0000362 ! epidermal cell
relationship: develops_from CL:0000538 ! epidermal initial

[Term]
id: CL:0000283
name: pstO/ALC
def: "Anterior-like cell that expresses the ecmO promoter and that can move to the position normally occupied by the pstO cells." [DictyBase:DDB]
is_a: CL:0000265 ! anterior like cell

[Term]
id: CL:0000284
name: companion cell
def: "A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [ISBN:0879015322]
is_a: CL:0000630 ! supportive cell
is_a: CL:0000668 ! parenchymal cell

[Term]
id: CL:0000285
name: stalk cell
def: "Vacuolated cell located at the center of the stalk tube that has a cell wall composed of cellulose and that die upon terminal differentiation. Stalk cells provide structural support for the fruiting body." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000286
name: hyphal cell
def: "A cell of a filament of a fungal mycelium." [ISBN:08199377X]
is_a: CL:0000521 ! fungal cell

[Term]
id: CL:0000287
name: eye photoreceptor cell
is_a: CL:0000210 ! photoreceptor cell

[Term]
id: CL:0000288
name: synergid
def: "A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization." [ISBN:047125208]
is_a: CL:0000610 ! plant cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000289
name: chemotactic amoeboid cell (sensu Mycetozoa)
def: "Starved cell that secretes and responds to chemoattractants (cAMP)." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)
is_a: CL:0000732 ! amoeboid cell

[Term]
id: CL:0000290
name: xylem fiber cell
def: "A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." [ISBN:0471245208]
is_a: CL:0000293 ! structural cell
is_a: CL:0000298 ! xylem element

[Term]
id: CL:0000291
name: spore (sensu Mycetozoa)
def: "Dormant cell protected by a spore coat." [DictyBase:DDB]
is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa)

[Term]
id: CL:0000292
name: guard cell
def: "One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." [ISBN:0471245208]
synonym: "stomatal guard cell" EXACT []
is_a: CL:0000362 ! epidermal cell
is_a: CL:0000610 ! plant cell
relationship: develops_from CL:0000262 ! guard mother cell

[Term]
id: CL:0000293
name: structural cell
def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000294
name: sieve cell
def: "A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants." [ISBN:0471245208]
is_a: CL:0000268 ! sieve element

[Term]
id: CL:0000295
name: somatotropin secreting cell
alt_id: CL:0000471
def: "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [SANBI:mhl]
synonym: "growth hormone secreting cell" RELATED []
synonym: "somatotrope" RELATED []
synonym: "somatotroph" RELATED []
synonym: "somatotrophin secreting cell" EXACT []
synonym: "somatotropic cell" EXACT []
synonym: "somatrophic cell" RELATED []
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0000638 ! acidophil cell

[Term]
id: CL:0000296
name: vegetative cell
def: "Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus." [ISBN:0140514031, TAIR:lr]
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000297
name: socket cell
def: "A cell that surrounds a trichome and provides support for the trichome." [PMID:10938806]
is_a: CL:0000362 ! epidermal cell
is_a: CL:0000630 ! supportive cell
relationship: develops_from CL:0000538 ! epidermal initial

[Term]
id: CL:0000298
name: xylem element
def: "A cell composing the xylem." [ISBN:0471245208]
is_a: CL:0000363 ! axial cell
is_a: CL:0000627 ! transporting cell

[Term]
id: CL:0000299
name: trichoblast
def: "Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair." [ISBN:0471245208]
synonym: "hair cell" EXACT []
is_a: CL:0000538 ! epidermal initial

[Term]
id: CL:0000300
name: gamete
synonym: "haploid germ cell" RELATED []
synonym: "haploid nucleated cell" EXACT []
xref: FBbt:00005412
xref: FMA:18649
is_a: CL:0000039 ! germ line cell
is_a: CL:0000413 ! haploid cell

[Term]
id: CL:0000301
name: pole cell
xref: FBbt:00000092
is_a: CL:0000548 ! animal cell
is_a: CL:0000670 ! primordial germ cell

[Term]
id: CL:0000302
name: IgM B cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000303
name: IgG B cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se, and IgG isotypes vary by species; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000304
name: IgA B cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se, and IgA isotypes vary by species. Consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000305
name: IgE B cell
def: "OBSOLETE (was not defined before being made obsolete)." []
comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead.
is_obsolete: true

[Term]
id: CL:0000306
name: crystallin accumulating cell
synonym: "cone cell" EXACT []
synonym: "lens cell" EXACT []
xref: FBbt:00004193
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000307
name: tracheal epithelial cell
synonym: "tracheocyte" EXACT []
xref: FBbt:00005038
is_a: CL:0000066 ! epithelial cell
relationship: develops_from CL:0000377 ! tracheoblast

[Term]
id: CL:0000308
name: metal ion accumulating cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000309
name: copper accumulating cell
synonym: "cuprophilic cell" EXACT []
is_a: CL:0000308 ! metal ion accumulating cell

[Term]
id: CL:0000310
name: iron accumulating cell
is_a: CL:0000308 ! metal ion accumulating cell

[Term]
id: CL:0000311
name: keratin accumulating cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000312
name: keratinocyte
def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [MESH:A.11.436.397]
synonym: "malpighian cell" EXACT []
is_a: CL:0000311 ! keratin accumulating cell

[Term]
id: CL:0000313
name: serous secreting cell
is_a: CL:0000159 ! seromucus secreting cell

[Term]
id: CL:0000314
name: milk secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000315
name: tears secreting cell
def: "A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea." [MESH:A.12.200.882]
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000316
name: ray initial
def: "A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem." [ISBN:0471245208]
is_a: CL:0000272 ! cambial initial

[Term]
id: CL:0000317
name: sebum secreting cell
def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." [MESH:A.12.200.702]
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000318
name: sweat secreting cell
def: "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." [MESH:A.12.200.849]
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000319
name: mucus secreting cell
synonym: "mucous cell" EXACT []
is_a: CL:0000159 ! seromucus secreting cell

[Term]
id: CL:0000320
name: megasporocyte
def: "A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." [ISBN:0471245208]
synonym: "archesporial cell" EXACT []
synonym: "megaspore mother cell" EXACT []
is_a: CL:0000039 ! germ line cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000321
name: seminal fluid secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000322
name: pneumocyte
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000323
name: lysozyme secreting cell
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000324
name: metanephric mesenchyme stem cell
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0000548 ! animal cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000325
name: stuff accumulating cell
def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000326
name: glycogen accumulating cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000327
name: extracellular matrix secreting cell
is_a: CL:0000151 ! secretory cell
is_a: CL:0000499 ! stromal cell

[Term]
id: CL:0000328
name: myelin accumulating cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000329
name: oxygen accumulating cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000330
name: collenchymal cell
def: "An elongated living cell with unevenly thickened nonlignified primary walls." [ISBN:0471245208]
is_a: CL:0000063 ! cell by histology
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000331
name: tracheid
def: "A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements." [ISBN:0471245208]
is_a: CL:0000672 ! tracheary element

[Term]
id: CL:0000332
name: atrichoblast
def: "A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair." [ISBN:0387987819]
synonym: "non-hair cell" RELATED []
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000538 ! epidermal initial

[Term]
id: CL:0000333
name: neural crest cell
def: "A cell of the strip of specialized ectoderm flanking each side of the embryonal neural plate, which after the closure of the neural tube, forms a column of isolated cells along the dorsal aspect of the neural tube. Most of the cranial and all of the spinal sensory ganglion cells arise by differentiation of neural crest cells." [MESH:A.16.254.600]
is_a: CL:0000219 ! motile cell
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000334
name: vegetative cell (sensu Fungi)
synonym: "yeast-form" RELATED []
xref: FAO:0000032
is_a: CL:0000521 ! fungal cell

[Term]
id: CL:0000335
name: mesenchyme condensation cell
relationship: develops_from CL:0000134 ! mesenchymal cell

[Term]
id: CL:0000336
name: adrenal medulla cell
synonym: "chromafin cell" EXACT []
relationship: develops_from CL:0000011 ! trunk neural crest cell

[Term]
id: CL:0000337
name: neuroblast (sensu Vertebrata)
synonym: "neuroblast" BROAD []
is_a: CL:0000031 ! neuroblast

[Term]
id: CL:0000338
name: neuroblast (sensu Nematoda and Protostomia)
synonym: "neuroblast" BROAD []
is_a: CL:0000031 ! neuroblast

[Term]
id: CL:0000339
name: glioblast (sensu Vertebrata)
is_a: CL:0000030 ! glioblast
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)

[Term]
id: CL:0000340
name: glioblast (sensu Nematoda and Protostomia)
is_a: CL:0000030 ! glioblast
is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000341
name: pigment cell (sensu Nematoda and Protostomia)
is_a: CL:0000147 ! pigment cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000342
name: pigment cell (sensu Vertebrata)
is_a: CL:0000147 ! pigment cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000343
name: visual pigment cell (sensu Vertebrata)
is_a: CL:0000149 ! visual pigment cell
is_a: CL:0000342 ! pigment cell (sensu Vertebrata)

[Term]
id: CL:0000344
name: non-visual cell (sensu Vertebrata)
is_a: CL:0000342 ! pigment cell (sensu Vertebrata)

[Term]
id: CL:0000345
name: dental papilla cell
relationship: develops_from CL:0000008 ! cranial neural crest cell

[Term]
id: CL:0000346
name: hair papilla cell
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0000347
name: scleral cell
def: "A cell of the sclera of the eye." [GOC:add]
is_a: CL:0000293 ! structural cell
relationship: develops_from CL:0000008 ! cranial neural crest cell

[Term]
id: CL:0000348
name: choroidal cell of the eye
def: "A cell of the choroid of the eye." [GOC:add]
is_a: CL:0000293 ! structural cell
relationship: develops_from CL:0000008 ! cranial neural crest cell

[Term]
id: CL:0000349
name: extraembryonic cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000350
name: amnioserosal cell
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000351
name: trophoblast cell
def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [MESH:A.11.936]
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000352
name: epiblast cell
synonym: "embryonic stem cell" RELATED []
is_a: CL:0000052 ! totipotent stem cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000353
name: blastoderm cell
def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:A.11.104]
synonym: "blastomere" EXACT []
is_a: CL:0000007 ! early embryonic cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000354
name: blastemal cell
is_a: CL:0000048 ! multi fate stem cell

[Term]
id: CL:0000355
name: muscle stem cell
is_a: CL:0000035 ! single fate stem cell
is_a: CL:0000548 ! animal cell
is_a: CL:0000680 ! muscle precursor cell

[Term]
id: CL:0000356
name: hair matrix stem cell
is_a: CL:0000035 ! single fate stem cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000357
name: stratified epithelial stem cell
is_a: CL:0000036 ! epithelial fate stem cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000358
name: sphincter associated smooth muscle cell
is_a: CL:0000192 ! smooth muscle cell

[Term]
id: CL:0000359
name: vascular associated smooth muscle cell
is_a: CL:0000192 ! smooth muscle cell

[Term]
id: CL:0000360
name: morula cell
def: "A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass." [MESH:A.16.254.270.550]
is_a: CL:0000007 ! early embryonic cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000361
name: gastrula cell
def: "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." [MESH:A.16.254.412]
is_a: CL:0000007 ! early embryonic cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000362
name: epidermal cell
def: "A cell found in the outermost layer of the organism." [MA:ma]
xref: FMA:62411
is_a: CL:0000076 ! squamous epithelial cell

[Term]
id: CL:0000363
name: axial cell
def: "A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system." [ISBN:0471245208]
is_a: CL:0000293 ! structural cell
relationship: develops_from CL:0000009 ! fusiform initial

[Term]
id: CL:0000364
name: ray cell
def: "A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." [ISBN:0471245208]
is_a: CL:0000293 ! structural cell
relationship: develops_from CL:0000316 ! ray initial

[Term]
id: CL:0000365
name: zygote
def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208]
xref: TAIR:0000423
is_a: CL:0000220 ! cell by lineage
is_a: CL:0000548 ! animal cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000366
name: sperm cell (sensu Viridiplantae)
def: "Male gamete, part of male germ unit." [ISBN:0471245208]
synonym: "gametophyte sperm cell" RELATED []
synonym: "male gametophyte sperm cell" RELATED []
synonym: "pollen germ cell " RELATED []
xref: TAIR:0000084
is_a: CL:0000408 ! male gamete
relationship: develops_from CL:0000280 ! generative cell

[Term]
id: CL:0000367
name: sheath cell (sensu Nematoda)
synonym: "glial cell (sensu Nematoda)" RELATED []
is_a: CL:0000619 ! support cell (sensu Nematoda)

[Term]
id: CL:0000368
name: myrosin cell
def: "Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae." [ISBN:0471245208]
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000369
name: single cell sarcomere
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0000370
name: transfer cell
def: "Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes." [ISBN:0471245208]
synonym: "intermediary cell" RELATED []
is_a: CL:0000627 ! transporting cell
is_a: CL:0000668 ! parenchymal cell

[Term]
id: CL:0000371
name: protoplast
def: "The cell protoplasm after removal of the cell wall." [ISBN:08199377X]
is_a: CL:0000578 ! experimentally modified cell

[Term]
id: CL:0000372
name: tormogen cell
synonym: "socket cell" RELATED []
xref: FBbt:00005171
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000373
name: histoblast
xref: FBbt:00001789
is_a: CL:0000146 ! simple columnar epithelial cell

[Term]
id: CL:0000374
name: trichogen cell
synonym: "hair cell" EXACT []
xref: FBbt:00005169
is_a: CL:0000098 ! sensory epithelial cell

[Term]
id: CL:0000375
name: osteoprogenitor cell
is_a: CL:0000035 ! single fate stem cell
relationship: develops_from CL:0000335 ! mesenchyme condensation cell

[Term]
id: CL:0000376
name: humidity receptor cell
is_a: CL:0000006 ! receptor cell (sensu Animalia)

[Term]
id: CL:0000377
name: tracheoblast
is_a: CL:0000069 ! branched duct epithelial cell

[Term]
id: CL:0000378
name: support cell (sensu Nematoda and Protostomia)
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000379
name: sensory processing neuron
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000380
name: thecogen cell
synonym: "sheath cell" EXACT []
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000381
name: neurosecretory neuron
xref: FBbt:00005130
is_a: CL:0000527 ! efferent neuron

[Term]
id: CL:0000382
name: scolopidium
synonym: "scolopale cell" EXACT []
xref: FBbt:00005217
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000383
name: nephrogenic mesenchyme stem cell
is_a: CL:0000048 ! multi fate stem cell
relationship: develops_from CL:0000134 ! mesenchymal cell

[Term]
id: CL:0000384
name: ligament cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000385
name: prohemocyte (sensu Nematoda and Protostomia)
xref: FBbt:00005062
is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000386
name: attachment cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000387
name: hemocyte (sensu Nematoda and Protostomia)
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)
relationship: develops_from CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000388
name: tendon cell
synonym: "muscle attachment cell" EXACT []
is_a: CL:0000386 ! attachment cell

[Term]
id: CL:0000389
name: socket cell (sensu Nematoda)
is_a: CL:0000619 ! support cell (sensu Nematoda)
is_a: CL:0000658 ! cuticle secreting cell

[Term]
id: CL:0000390
name: blood cell (sensu Nematoda and Protostomia)
is_a: CL:0000081 ! blood cell

[Term]
id: CL:0000391
name: podocyte (sensu Diptera)
relationship: develops_from CL:0000395 ! procrystal cell

[Term]
id: CL:0000392
name: crystal cell
is_a: CL:0000391 ! podocyte (sensu Diptera)

[Term]
id: CL:0000393
name: electrically responsive cell
def: "A cell whose function is determined by its response to an electric signal." [FB:ma]
is_a: CL:0000211 ! electrically active cell

[Term]
id: CL:0000394
name: plasmatocyte
xref: FBbt:00001685
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000395
name: procrystal cell
xref: FBbt:00001689
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000396
name: lamellocyte
xref: FBbt:00001687
is_a: CL:0000394 ! plasmatocyte

[Term]
id: CL:0000397
name: ganglion interneuron
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000398
name: polygonal cell
xref: FBbt:00001691
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000399
name: phloem element
is_a: CL:0000627 ! transporting cell
relationship: develops_from CL:0000264 ! phloem initial

[Term]
id: CL:0000400
name: pavement cell
def: "An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." [ISBN:087694289]
is_a: CL:0000362 ! epidermal cell
relationship: develops_from CL:0000538 ! epidermal initial

[Term]
id: CL:0000401
name: macrophage (sensu Diptera)
xref: FBbt:00001686
is_a: CL:0000394 ! plasmatocyte

[Term]
id: CL:0000402
name: CNS interneuron
is_a: CL:0000099 ! interneuron
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000404
name: electrically signaling cell
def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma]
is_a: CL:0000211 ! electrically active cell

[Term]
id: CL:0000405
name: neuroepidermoblast
xref: FBbt:00005148
is_a: CL:0000338 ! neuroblast (sensu Nematoda and Protostomia)

[Term]
id: CL:0000406
name: CNS short range interneuron
is_a: CL:0000402 ! CNS interneuron

[Term]
id: CL:0000407
name: scolopidial ligament cell
xref: FBbt:00005221
is_a: CL:0000384 ! ligament cell

[Term]
id: CL:0000408
name: male gamete
is_a: CL:0000300 ! gamete

[Term]
id: CL:0000409
name: scolopidial sheath cell
xref: FBbt:00005219
is_a: CL:0000618 ! sheath cell

[Term]
id: CL:0000410
name: CNS long range interneuron
is_a: CL:0000402 ! CNS interneuron

[Term]
id: CL:0000411
name: hypodermal cell
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000228 ! multinucleate cell

[Term]
id: CL:0000412
name: polyploid cell
def: "A cell whose nucleus, or nuclei, each contain more than two haploid genomes." [FB:ma]
is_a: CL:0000414 ! cell by ploidy

[Term]
id: CL:0000413
name: haploid cell
def: "A cell whose nucleus contains a single haploid genome." [FB:ma]
is_a: CL:0000414 ! cell by ploidy

[Term]
id: CL:0000414
name: cell by ploidy
def: "A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." [FB:ma]
is_a: CL:0000012 ! cell by class

[Term]
id: CL:0000415
name: diploid cell
def: "A cell whose nucleus has two haploid genomes." [FB:ma]
is_a: CL:0000414 ! cell by ploidy

[Term]
id: CL:0000416
name: polytene cell
is_a: CL:0000412 ! polyploid cell

[Term]
id: CL:0000417
name: endopolyploid cell
is_a: CL:0000412 ! polyploid cell

[Term]
id: CL:0000418
name: arcade cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000419
name: seam cell
is_a: CL:0000036 ! epithelial fate stem cell

[Term]
id: CL:0000420
name: syncytial epithelial cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000421
name: coelomocyte
is_a: CL:0000080 ! circulating cell
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000422
name: mitogenic signaling cell
def: "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." [FB:ma]
is_a: CL:0000144 ! cell by function
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000423
name: tip cell
is_a: CL:0000422 ! mitogenic signaling cell

[Term]
id: CL:0000424
name: excretory cell
is_a: CL:0000151 ! secretory cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000425
name: pore cell
def: "Forms the terminal part of the cuticle-lined excretory duct of C. elegans." [JB:jb]
is_a: CL:0000548 ! animal cell
is_a: CL:0000658 ! cuticle secreting cell

[Term]
id: CL:0000426
name: scaffold cell
is_a: CL:0000445 ! apoptosis fated cell

[Term]
id: CL:0000427
name: GLR cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000428
name: yolk cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000429
name: imaginal disc cell
is_a: CL:0000146 ! simple columnar epithelial cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000430
name: xanthophore
def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." [SANBI:mhl]
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005002 ! xanthoblast

[Term]
id: CL:0000431
name: iridophore
def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." [SANBI:mhl]
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005001 ! iridoblast

[Term]
id: CL:0000432
name: reticular cell
is_a: CL:0000057 ! fibroblast

[Term]
id: CL:0000433
name: functional megaspore
def: "In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." [TAIR:lr]
is_a: CL:0000250 ! megaspore

[Term]
id: CL:0000434
name: eccrine cell
def: "A secretory cell that discharges its product without loss of cytoplasm." [ISBN:0198547684]
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000435
name: alkali secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000436
name: vaginal lubricant secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000437
name: follicle stimulating hormone secreting cell
synonym: "delta basophil" EXACT []
synonym: "gonadotroph" EXACT []
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0000639 ! basophil cell of anterior lobe of hypophysis

[Term]
id: CL:0000438
name: luteinizing hormone secreting cell
synonym: "delta basophila" EXACT []
synonym: "gonadotroph" RELATED []
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0000639 ! basophil cell of anterior lobe of hypophysis

[Term]
id: CL:0000439
name: prolactin secreting cell
def: "An acidophilic cell of the anterior pituitary that produces prolactin." [SANBI:mhl]
synonym: "epsilon-acidophil" EXACT []
synonym: "lactotrope" EXACT []
synonym: "lactotroph" EXACT []
synonym: "lactotropic cell" EXACT []
synonym: "mammotrope" EXACT []
synonym: "mammotroph" EXACT []
synonym: "mammotrophic cell" EXACT []
synonym: "mammotropic cell" EXACT []
xref: FMA:83096
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0000638 ! acidophil cell

[Term]
id: CL:0000440
name: melanocyte stimulating hormone secreting cell
def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [SANBI:mhl]
synonym: "melanotrope" EXACT []
synonym: "melanotroph" EXACT []
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000441
name: follicle stem cell
xref: FBbt:00004903
is_a: CL:0000036 ! epithelial fate stem cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000442
name: follicular dendritic cell
def: "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." [ISBN:127520252]
comment: Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451.
is_a: CL:0000473 ! defensive cell

[Term]
id: CL:0000443
name: calcitonin secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000444
name: obliquely striated muscle cell
is_a: CL:0000737 ! striated muscle cell

[Term]
id: CL:0000445
name: apoptosis fated cell
is_a: CL:0000144 ! cell by function
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000446
name: parathyroid hormone secreting cell
synonym: "chief cell" EXACT []
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000447
name: carbohydrate secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000448
name: white fat cell
is_a: CL:0000136 ! fat cell
relationship: develops_from CL:0000005 ! fibroblast neural crest derived

[Term]
id: CL:0000449
name: brown fat cell
def: "A cell from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [MESH:A.10.165.114.322]
is_a: CL:0000136 ! fat cell

[Term]
id: CL:0000450
name: lipocyte
is_a: CL:0000136 ! fat cell

[Term]
id: CL:0000451
name: dendritic cell
def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [GOC:add, ISBN:0781735149]
synonym: "interdigitating cell" RELATED []
synonym: "veiled cell" RELATED []
is_a: CL:0000738 ! leukocyte

[Term]
id: CL:0000452
name: thyroid hormone secreting cell
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000453
name: Langerhans cell
def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [GO_REF:0000031, GOC:add, GOC:amm, ISBN:0721601464, ISBN:0781735149, PMID:17850486, PMID:18082389]
xref: DC_CL:0000021
is_a: CL:0000990 ! conventional dendritic cell

[Term]
id: CL:0000454
name: epinephrin secreting cell
is_a: CL:0000457 ! biogenic amine secreting cell

[Term]
id: CL:0000455
name: starch sheath cell
def: "A cell characterized by conspicuous and rather stable accumulation of starch." [ISBN:044174520]
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000456
name: mineralocorticoid secreting cell
is_a: CL:0000174 ! steroid hormone secreting cell

[Term]
id: CL:0000457
name: biogenic amine secreting cell
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000458
name: serotin secreting cell
is_a: CL:0000457 ! biogenic amine secreting cell

[Term]
id: CL:0000459
name: norepinephrin secreting cell
is_a: CL:0000457 ! biogenic amine secreting cell

[Term]
id: CL:0000460
name: glucocorticoid secreting cell
is_a: CL:0000174 ! steroid hormone secreting cell

[Term]
id: CL:0000461
name: renin secreting cell
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000462
name: adepithelial cell
xref: FBbt:00003219
is_a: CL:0000680 ! muscle precursor cell

[Term]
id: CL:0000463
name: epidermal cell (sensu Insecta)
def: "A columnar/cuboidal epithelial cell which secretes cuticle from its apical side." [FlyBase:ds]
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
relationship: develops_from CL:0000464 ! epidermoblast

[Term]
id: CL:0000464
name: epidermoblast
xref: FBbt:00004994
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000548 ! animal cell
relationship: develops_from CL:0000114 ! surface ectodermal cell

[Term]
id: CL:0000465
name: cardioblast (sensu Arthropoda)
xref: FBbt:00001666
is_a: CL:0000513 ! cardiac muscle myoblast

[Term]
id: CL:0000467
name: adrenocorticotropic hormone secreting cell
alt_id: CL:0000640
def: "A basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin." [SANBI:mhl]
synonym: "adrenocorticotrophic hormone secreting cell" EXACT []
synonym: "corticotrope" EXACT []
synonym: "corticotroph" EXACT []
synonym: "corticotrophin hormone secreting cell" RELATED []
synonym: "corticotropin hormone secreting cell" RELATED []
xref: FMA:83098
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0000639 ! basophil cell of anterior lobe of hypophysis

[Term]
id: CL:0000468
name: neuroglioblast
xref: FBbt:00005147
is_a: CL:0000047 ! neuronal stem cell
is_a: CL:0000055 ! non-terminally differentiated cell

[Term]
id: CL:0000469
name: ganglion mother cell
xref: FBbt:00005149
is_a: CL:0000468 ! neuroglioblast

[Term]
id: CL:0000470
name: digestive enzyme secreting cell
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000472
name: chlorenchyma cell
def: "Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue." [ISBN:0471245208]
is_a: CL:0000628 ! photosynthetic cell
is_a: CL:0000668 ! parenchymal cell

[Term]
id: CL:0000473
name: defensive cell
def: "A cell whose primary function is to protect the organism." [JB:jb]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000474
name: pericardial cell
xref: FBbt:00003184
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000475
name: degenerate megaspore
def: "In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." [TAIR:lr]
is_a: CL:0000250 ! megaspore

[Term]
id: CL:0000476
name: thyroid stimulating hormone secreting cell
def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin." [SANBI:mhl]
synonym: "beta-basophil" EXACT []
synonym: "thyrotrope" EXACT []
synonym: "thyrotroph" EXACT []
xref: FMA:83099
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0000639 ! basophil cell of anterior lobe of hypophysis

[Term]
id: CL:0000477
name: follicle cell
xref: FBbt:00004904
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
relationship: develops_from CL:0000441 ! follicle stem cell

[Term]
id: CL:0000478
name: oxytocin stimulating hormone secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000479
name: vasopressin stimulating hormone secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000480
name: secretin stimulating hormone secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000481
name: cholecystokin stimulating hormone secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000482
name: juvenile hormone secreting cell
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000483
name: bombesin stimulating hormone secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000484
name: connective tissue type mast cell
def: "A mast cell of the connective tissue." [GOC:add]
is_a: CL:0000097 ! mast cell

[Term]
id: CL:0000485
name: mucosal type mast cell
def: "A mast cell of a mucosal tissue." [GOC:add]
is_a: CL:0000097 ! mast cell

[Term]
id: CL:0000486
name: garland cell
xref: FBbt:00005059
is_a: CL:0000227 ! binucleate cell
is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000487
name: oenocyte
def: "A large secretory cell found in clusters underlying the epidermis of the abdominal segments of larval abdominal segments." [GOC:bf, PMID:11171397]
xref: FBbt:00004995
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000488
name: visible light photoreceptor cell
is_a: CL:0000210 ! photoreceptor cell

[Term]
id: CL:0000489
name: scotopic photoreceptor cell
is_a: CL:0000210 ! photoreceptor cell

[Term]
id: CL:0000490
name: photopic photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000491
name: cytotoxic T cell
def: "OBSOLETE: A cell responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody." []
comment: This term had an incorrect definition and was overly broad. Consider using 'cytotoxic T cell ; CL:0000910' (in most cases) or another lymphocyte cell type if cytotoxicity is shown to be part of the cell's phenotype in a particular experimental situation.
is_obsolete: true

[Term]
id: CL:0000492
name: CD4-positive helper T cell
def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [GO_REF:0000031, GOC:add, GOC:pam, ISBN:0781735149, MESH:A.11.118.637.555.567.569.200.400]
synonym: "CD4-positive helper T lymphocyte" EXACT []
synonym: "CD4-positive helper T-cell" EXACT []
synonym: "CD4-positive helper T-lymphocyte" EXACT []
synonym: "CD4-positive T-helper cell" EXACT []
xref: FMA:70572
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000912 ! helper T cell
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell

[Term]
id: CL:0000493
name: regulatory T cell
def: "OBSOLETE: Subpopulation of CD4+ cells which induce CD8+ suppressor T cells to suppress antibody production by B cells. They also stimulate other cellular immune responses." []
comment: This term was defined too narrowly; consider using the term 'regulatory T cell ; CL:0000815' instead.
is_obsolete: true

[Term]
id: CL:0000494
name: UV sensitive photoreceptor cell
is_a: CL:0000210 ! photoreceptor cell

[Term]
id: CL:0000495
name: blue sensitive photoreceptor cell
is_a: CL:0000490 ! photopic photoreceptor cell

[Term]
id: CL:0000496
name: green sensitive photoreceptor cell
is_a: CL:0000490 ! photopic photoreceptor cell

[Term]
id: CL:0000497
name: red sensitive photoreceptor cell
is_a: CL:0000490 ! photopic photoreceptor cell

[Term]
id: CL:0000498
name: inhibitory interneuron
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000499
name: stromal cell
def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [MESH:A.11.329.830]
relationship: develops_from CL:0000134 ! mesenchymal cell

[Term]
id: CL:0000500
name: follicular epithelial cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000501
name: granulosa cell
def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [MESH:A.05.360.319.114.630.535.200]
xref: FMA:18718
is_a: CL:0000174 ! steroid hormone secreting cell

[Term]
id: CL:0000502
name: D cell
def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:A.03.492.766.440.175]
synonym: "type D enteroendocrine cell" EXACT []
xref: FMA:62935
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000172 ! somatostatin secreting cell

[Term]
id: CL:0000503
name: theca cell
def: "A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells." [MESH:A.05.360.319.114.630.535.400]
xref: FMA:18690
is_a: CL:0000499 ! stromal cell
is_a: CL:0000593 ! androgen secreting cell

[Term]
id: CL:0000504
name: enterochromaffin cell
def: "An irregular-shaped argyrophilic cell which produces histamine, chromogranin A/pancreastatin, and an as yet unidentified peptide hormone. They are the predominant endocrine cell type of the oxyntic (acid-producing) mucosa of the mammalian stomach. ECL cells respond to gastrin by releasing their secretory products and this source of histamine acts as the positive paracrine stimulator of the release of hydrochloric acid from the parietal cell." [MESH:A.06.224.365]
synonym: "argentaffin cell" EXACT []
synonym: "Kulchitsky cell" EXACT []
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000505 ! substance P secreting cell
is_a: CL:0000506 ! enkephalin secreting cell

[Term]
id: CL:0000505
name: substance P secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000506
name: enkephalin secreting cell
is_a: CL:0000507 ! endorphin secreting cell

[Term]
id: CL:0000507
name: endorphin secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000508
name: G cell
def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin." [MESH:A.03.492.766.440.300]
synonym: "gastrin secreting cell" EXACT []
synonym: "type G enteroendocrine cell" EXACT []
xref: FMA:67609
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000509 ! gastrin secreting cell

[Term]
id: CL:0000509
name: gastrin secreting cell
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000510
name: Paneth cell
def: "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn). Paneth cells synthesize and secrete lysozyme and cryptdins." [MESH:A.03.492.411.369.700]
is_a: CL:0000131 ! gut endothelial cell
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000323 ! lysozyme secreting cell

[Term]
id: CL:0000511
name: androgen binding protein secreting cell
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000512
name: paracrine cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000513
name: cardiac muscle myoblast
alt_id: CL:0000714
def: "A precursor cell destined to differentiate into cardiac myocytes." [MESH:A.11.635.470]
synonym: "cardioblast" RELATED []
is_a: CL:0000056 ! myoblast

[Term]
id: CL:0000514
name: smooth muscle myoblast
def: "A precursor cell destined to differentiate into smooth muscle myocytes." [MESH:A.11.635.510]
synonym: "satellite cell" RELATED []
is_a: CL:0000056 ! myoblast

[Term]
id: CL:0000515
name: skeletal muscle myoblast
def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl]
is_a: CL:0000056 ! myoblast

[Term]
id: CL:0000516
name: perineuronal satellite cell
def: "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." [MESH:A.08.340.685]
synonym: "perineural satellite cell" EXACT []
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0000243 ! glial cell (sensu Vertebrata)
relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata)

[Term]
id: CL:0000517
name: macrophage derived foam cell
def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add]
is_a: CL:0000891 ! foam cell
relationship: develops_from CL:0000235 ! macrophage

[Term]
id: CL:0000518
name: phagocyte (sensu Vertebrata)
is_a: CL:0000234 ! phagocyte
is_a: CL:0000766 ! myeloid leukocyte

[Term]
id: CL:0000519
name: phagocyte (sensu Nematoda and Protostomia)
is_a: CL:0000234 ! phagocyte
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000520
name: prokaryotic cell
is_a: CL:0000004 ! cell by organism

[Term]
id: CL:0000521
name: fungal cell
is_a: CL:0000255 ! eukaryotic cell

[Term]
id: CL:0000522
name: spore
def: "The reproductive structure of bacteria, fungi and cryptograms." [ISBN:08199377X]
is_a: CL:0000004 ! cell by organism
is_a: CL:0000520 ! prokaryotic cell
is_a: CL:0000521 ! fungal cell

[Term]
id: CL:0000523
name: mononuclear cytotrophoblast cell
is_a: CL:0000351 ! trophoblast cell

[Term]
id: CL:0000524
name: spheroplast
def: "A cell, usually of bacteria or yeast, which has partially lost its cell wall." [MESH:A.11.868]
synonym: "sphaeroplast" EXACT []
is_a: CL:0000371 ! protoplast

[Term]
id: CL:0000525
name: syncytiotrophoblast cell
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000351 ! trophoblast cell

[Term]
id: CL:0000526
name: afferent neuron
def: "A neuron which conveys sensory information centrally from the periphery." [MESH:A.08.663.650]
synonym: "input neuron" EXACT []
is_a: CL:0000029 ! neuron neural crest derived

[Term]
id: CL:0000527
name: efferent neuron
def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:A.08.663.655]
synonym: "output neuron" EXACT []
is_a: CL:0000029 ! neuron neural crest derived

[Term]
id: CL:0000528
name: nitrergic neuron
def: "A nerve cell where transmission is mediated by nitric oxide." [MESH:A.08.663.748]
is_a: CL:0000107 ! autonomic neuron

[Term]
id: CL:0000529
name: pigmented epithelial cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
relationship: develops_from CL:0000710 ! neuroepithelial cell

[Term]
id: CL:0000530
name: primary neuron
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000531
name: primary sensory neuron
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000530 ! primary neuron

[Term]
id: CL:0000532
name: CAP motoneuron
is_a: CL:0000533 ! primary motor neuron

[Term]
id: CL:0000533
name: primary motor neuron
is_a: CL:0000100 ! motor neuron
is_a: CL:0000530 ! primary neuron

[Term]
id: CL:0000534
name: primary interneuron
is_a: CL:0000099 ! interneuron
is_a: CL:0000530 ! primary neuron

[Term]
id: CL:0000535
name: secondary neuron
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000536
name: secondary motor neuron
is_a: CL:0000100 ! motor neuron
is_a: CL:0000535 ! secondary neuron

[Term]
id: CL:0000537
name: antipodal cell
def: "A cell located at the chalazal end of the mature embryo sac in angiosperms." [ISBN:047125208]
is_a: CL:0000039 ! germ line cell
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000538
name: epidermal initial
def: "A relatively unspecialized cell that will give rise to specialized cell types of the epidermis." [TAIR:lr]
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000685 ! meristematic cell

[Term]
id: CL:0000539
name: idioblast
def: "A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue." [ISBN:0471245208]
is_obsolete: true

[Term]
id: CL:0000540
name: neuron
def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [MESH:A.08.663]
synonym: "nerve cell" EXACT []
xref: FBbt:00005106
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000404 ! electrically signaling cell
relationship: develops_from CL:0000031 ! neuroblast

[Term]
id: CL:0000541
name: melanoblast
def: "A cell that originates from the neural crest and differentiates into a pigment cell." [SANBI:mhl]
comment: Derived from UBERON:0002342 neural crest.
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0000542
name: lymphocyte
def: "A cell of the B cell, T cell, or natural killer cell lineage." [GOC:add, ISBN:0781735149]
is_a: CL:0000738 ! leukocyte
relationship: develops_from CL:0000051 ! common lymphoid progenitor

[Term]
id: CL:0000543
name: sieve tube member
def: "One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment." [ISBN:0471245208]
synonym: "sieve tube element" EXACT []
is_a: CL:0000268 ! sieve element

[Term]
id: CL:0000544
name: slowly adapting mechanoreceptor cell
is_a: CL:0000199 ! mechanoreceptor cell

[Term]
id: CL:0000545
name: T-helper 1 cell
def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "helper T cell type 1" EXACT []
synonym: "Th1 cell" EXACT []
synonym: "Th1 T cell" EXACT []
synonym: "Th1 T lymphocyte" EXACT []
synonym: "Th1 T-cell" EXACT []
synonym: "Th1 T-lymphocyte" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell

[Term]
id: CL:0000546
name: T-helper 2 cell
def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "helper T cell type 2" EXACT []
synonym: "Th2 cell" EXACT []
synonym: "Th2 T cell" EXACT []
synonym: "Th2 T lymphocyte" EXACT []
synonym: "Th2 T-cell" EXACT []
synonym: "Th2 T-lymphocyte" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell

[Term]
id: CL:0000547
name: proerythroblast
def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells." [ISBN:0721601464, MESH:A.11.118.290.350.200]
synonym: "pronormoblast" RELATED []
synonym: "rubriblast" EXACT [ISBN:0721601464]
is_a: CL:0000764 ! erythroid lineage cell
relationship: develops_from CL:0000038 ! erythroid progenitor cell

[Term]
id: CL:0000548
name: animal cell
is_a: CL:0000255 ! eukaryotic cell

[Term]
id: CL:0000549
name: basophilic erythroblast
def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared." [ISBN:0721601464]
synonym: "basophilic normoblast" EXACT [ISBN:0721601464]
synonym: "early erythroblast" EXACT [ISBN:0721601464]
synonym: "early normoblast" EXACT [ISBN:0721601464]
synonym: "prorubricyte" EXACT [ISBN:0721601464]
is_a: CL:0000765 ! erythroblast
relationship: develops_from CL:0000547 ! proerythroblast

[Term]
id: CL:0000550
name: polychromatophilic erythroblast
def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely blue color, but takes on an acidophilic tint, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps." [ISBN:0721601464]
synonym: "intermediate erythroblast" EXACT [ISBN:0721601464]
synonym: "intermediate normoblast" EXACT [ISBN:0721601464]
synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464]
synonym: "polychromatic normoblast" EXACT [ISBN:0721601464]
synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464]
synonym: "rubricyte" EXACT [ISBN:0721601464]
is_a: CL:0000765 ! erythroblast
relationship: develops_from CL:0000549 ! basophilic erythroblast

[Term]
id: CL:0000551
name: unimodal nocireceptor
is_a: CL:0000198 ! pain receptor cell

[Term]
id: CL:0000552
name: orthochromatic erythroblast
def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464]
synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464]
synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464]
synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464]
synonym: "pyknotic erythroblast" EXACT [ISBN:0721601464]
is_a: CL:0000765 ! erythroblast
relationship: develops_from CL:0000550 ! polychromatophilic erythroblast

[Term]
id: CL:0000553
name: megakaryocyte progenitor cell
def: "The earliest cytologically identifiable precursor in the thrombocytic series." [ISBN:0721601464]
synonym: "megacaryoblast" EXACT []
synonym: "megacaryocyte progenitor cell" EXACT []
synonym: "megakaryoblast" EXACT []
synonym: "promegacaryocyte" RELATED []
synonym: "promegakaryocyte" RELATED []
xref: FMA:84235
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000050 ! megakaryocyte erythroid progenitor cell

[Term]
id: CL:0000554
name: gastrin stimulating hormone secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000555
name: brush cell
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000556
name: megakaryocyte
def: "A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm." [ISBN:0721601464]
synonym: "megacaryocyte" EXACT []
synonym: "megalocaryocyte" EXACT []
synonym: "megalokaryocyte" EXACT []
is_a: CL:0000763 ! myeloid cell
relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell

[Term]
id: CL:0000557
name: granulocyte monocyte progenitor cell
def: "A progenitor cell that has plasma membrane part CD123, CD34, and CD45RA, lacks plasma membrane part CD19 and CD3, and is committed to the granulocyte and monocyte lineages." [GO_REF:0000031, GOC:add, GOC:amm, http://www.copewithcytokines.de, ISBN:0721601464, PMID:15684376, PMID:15867096, PMID:16551251]
synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de]
synonym: "CFU-GM" EXACT [ISBN:0721601464, PMID:15684376, PMID:15867096]
synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMID:15684376, PMID:15867096]
synonym: "GMP" EXACT [ISBN:0721601464, PMID:15684376, PMID:15867096]
synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMID:15684376, PMID:15867096]
xref: DC_CL:0000042
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0001026 ! CD71-positive common myeloid progenitor

[Term]
id: CL:0000558
name: reticulocyte
def: "An immature erythrocyte showing a basophilic reticulum under vital staining." [GOC:add, ISBN:0721601464]
is_a: CL:0000081 ! blood cell
is_a: CL:0000764 ! erythroid lineage cell
relationship: develops_from CL:0000552 ! orthochromatic erythroblast

[Term]
id: CL:0000559
name: promonocyte
def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte." [http://www.clt.astate.edu/wwilliam/, ISBN:0721601464]
comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000040 ! monoblast

[Term]
id: CL:0000560
name: band form neutrophil
def: "A late neutrophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil." [GOC:add, ISBN:0721601464]
synonym: "band" NARROW []
synonym: "band cell" EXACT []
synonym: "band form" EXACT []
synonym: "rod neutrophil" EXACT []
synonym: "stab cell" EXACT []
is_a: CL:0000776 ! immature neutrophil
relationship: develops_from CL:0000582 ! neutrophilic metamyelocyte

[Term]
id: CL:0000561
name: amacrine cell
def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer." [MESH:A.08.663.358.050]
synonym: "amacrine neuron" EXACT []
xref: FBbt:00005127
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000562
name: nucleate erythrocyte
def: "An erythrocyte having a nucleus." [GOC:add]
synonym: "RBC" BROAD []
synonym: "red blood cell" BROAD []
is_a: CL:0000232 ! erythrocyte

[Term]
id: CL:0000563
name: endospore
is_a: CL:0000520 ! prokaryotic cell

[Term]
id: CL:0000564
name: neutrophilic promyelocyte
def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, and containing a few, as yet undifferentiated, cytoplasmic granules." [GOC:add, ISBN:0721601464]
synonym: "neutrophilic premyelocyte" EXACT []
synonym: "neutrophilic progranulocyte" EXACT []
is_a: CL:0000836 ! promyelocyte
relationship: develops_from CL:0000042 ! neutrophilic myeloblast

[Term]
id: CL:0000565
name: fat body cell
def: "A cell whose primary function is intermediary metabolism." [FB:ma]
is_a: CL:0000181 ! metabolising cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000566
name: angioblastic mesenchymal cell
synonym: "angioblast" EXACT []
is_a: CL:0000048 ! multi fate stem cell
relationship: develops_from CL:0000134 ! mesenchymal cell

[Term]
id: CL:0000567
name: polymodal nocireceptor
is_a: CL:0000198 ! pain receptor cell

[Term]
id: CL:0000568
name: apud cell
def: "A cell that develops from primitive cell types in the neural crest. During ontogeny they migrate to the foregut and specific locations of the neuroendocrine system. Properly located these cells form part of the normal hormone producing tissues of the neuroendocrine system. If misdirected these cells may become hyperplastic, adenomatous, or malignant." [MESH:A.11.070]
is_a: CL:0000165 ! neuroendocrine cell

[Term]
id: CL:0000569
name: cardiac mesenchymal cell
def: "A mesenchymal cell found in the developing heart." [PMID:18816864]
is_a: CL:0000134 ! mesenchymal cell
relationship: develops_from CL:0000011 ! trunk neural crest cell

[Term]
id: CL:0000570
name: parafollicular cell
synonym: "C cell" EXACT []
xref: FMA:68653
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0000571
name: leucophore
def: "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." [SANBI:mhl]
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005003 ! leucoblast

[Term]
id: CL:0000573
name: retinal cone cell
def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:A.08.663.650.650.670.100]
xref: FMA:67748
is_a: CL:0000287 ! eye photoreceptor cell

[Term]
id: CL:0000574
name: erythrophore
def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." [SANBI:mhl]
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005004 ! pigment erythroblast

[Term]
id: CL:0000575
name: corneal epithelial cell
xref: FMA:70551
is_a: CL:0000076 ! squamous epithelial cell

[Term]
id: CL:0000576
name: monocyte
def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, http://www.clt.astate.edu/wwilliam/, MESH:A.11.118.637.555.652]
comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid.
is_a: CL:0000766 ! myeloid leukocyte
relationship: develops_from CL:0000559 ! promonocyte

[Term]
id: CL:0000577
name: enterochromaffin like cell
def: "One of a group of basal granular cells of the mammalian gut whose granules stain readily with silver and chromium salts. The cells secrete serotonin, substance P, and enkephalins. There are three types: gastric (antral mucosa), duodenal, and intestinal." [MESH:A.03.492.766.440.250]
synonym: "ECL cell" EXACT []
is_a: CL:0000164 ! enteroendocrine cell

[Term]
id: CL:0000578
name: experimentally modified cell
def: "A cell that has been changed as a consequence of a deliberate and specific experimental procedure." [FB:ma]
is_a: CL:0000000 ! cell

[Term]
id: CL:0000579
name: border follicle cell
xref: FBbt:00004905
is_a: CL:0000477 ! follicle cell

[Term]
id: CL:0000580
name: neutrophilic myelocyte
def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, differentiation of cytoplasmic granules has begun." [GOC:add, ISBN:0721601464]
is_a: CL:0000776 ! immature neutrophil
relationship: develops_from CL:0000564 ! neutrophilic promyelocyte

[Term]
id: CL:0000581
name: peritoneal macrophage
def: "A macrophage resident in the peritoneum under non-inflammatory conditions." [MESH:A.11.329.372.630, PMID:15771589]
comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+.
is_a: CL:0000864 ! tissue-resident macrophage

[Term]
id: CL:0000582
name: neutrophilic metamyelocyte
def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a meylocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented and its chromatin becomes coarse and clumped; and the cytoplasm becomes pink like that of a mature granulocyte." [GOC:add, ISBN:0721601464]
synonym: "juvenile neutrophil" EXACT []
is_a: CL:0000776 ! immature neutrophil
relationship: develops_from CL:0000580 ! neutrophilic myelocyte

[Term]
id: CL:0000583
name: alveolar macrophage
def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells." [GO_REF:0000031, GOC:ana, MESH:A.11.329.372.600]
comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-.
is_a: CL:0000864 ! tissue-resident macrophage

[Term]
id: CL:0000584
name: enterocyte
def: "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." [SANBI:mhl]
is_a: CL:0000239 ! brush border epithelial cell

[Term]
id: CL:0000585
name: null cell
def: "OBSOLETE: A class of lymphocytes characterized by the lack of surface markers specific for either T or B cells." []
comment: This term is rather archaic; consider using 'natural killer cell ; CL:0000623', 'pro-B cell ; CL:0000826', 'pro-T cell ; CL:0000827', or other appropriate lymphocyte-related term depending on the context.
is_obsolete: true

[Term]
id: CL:0000586
name: germ cell
def: "The reproductive cell in multicellular organisms." [MESH:A.05.360.490]
is_a: CL:0000039 ! germ line cell

[Term]
id: CL:0000587
name: cold sensing thermoreceptor cell
is_a: CL:0000205 ! thermoreceptor cell

[Term]
id: CL:0000588
name: odontoclast
def: "A specialized osteoclast associated with the absorption and removal of cementum." [GOC:add, MESH:A.11.329.679]
is_a: CL:0000092 ! osteoclast

[Term]
id: CL:0000589
name: inner hair cell
def: "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." [MESH:A.08.663.650.250.250]
synonym: "cochlear inner hair cell" EXACT []
xref: FMA:62365
is_a: CL:0000202 ! auditory hair cell

[Term]
id: CL:0000590
name: small luteal cell
is_a: CL:0000175 ! luteal cell
is_a: CL:0000179 ! progesterone secreting cell
relationship: develops_from CL:0000503 ! theca cell

[Term]
id: CL:0000591
name: warmth sensing thermoreceptor cell
is_a: CL:0000205 ! thermoreceptor cell

[Term]
id: CL:0000592
name: large luteal cell
is_a: CL:0000175 ! luteal cell
is_a: CL:0000177 ! testosterone secreting cell
relationship: develops_from CL:0000501 ! granulosa cell

[Term]
id: CL:0000593
name: androgen secreting cell
is_a: CL:0000174 ! steroid hormone secreting cell

[Term]
id: CL:0000594
name: skeletal muscle satellite cell
def: "An elongated, spindle-shaped, quiescent myoblast lying in close contact with adult skeletal muscle. They are thought to play a role in muscle repair and regeneration." [MESH:A.11.635.500.700]
is_a: CL:0000515 ! skeletal muscle myoblast

[Term]
id: CL:0000595
name: enucleate erythrocyte
def: "An erythrocyte lacking a nucleus." [GOC:add]
synonym: "RBC" BROAD []
synonym: "red blood cell" BROAD []
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000232 ! erythrocyte

[Term]
id: CL:0000596
name: sexual spore
synonym: "meiotically-derived spore" EXACT []
xref: FAO:0000017
is_a: CL:0000522 ! spore

[Term]
id: CL:0000597
name: microconidium
xref: FAO:0000028
is_a: CL:0000599 ! conidium

[Term]
id: CL:0000598
name: pyramidal cell
def: "A projection neuron in the cerebral cortex and the hippocampus. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region." [MESH:A.08.186.211.577.405.700]
synonym: "projection neuron" EXACT []
synonym: "pyramidal neuron" EXACT []
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000599
name: conidium
def: "A non-motile asexual spore that has not developed by cytoplasmic cleavage (see: sporangiospore ; CL:0000616) or free-cell formation (see: ascospore ; CL:0000607)." [ISBN:08199377X]
xref: FAO:0000024
is_a: CL:0000605 ! asexual spore

[Term]
id: CL:0000600
name: heterokaryon
def: "A fungal cell with two or more genetically distinct nuclei." [ISBN:08199377X]
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000521 ! fungal cell

[Term]
id: CL:0000601
name: outer hair cell
def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." [MESH:A.08.663.650.250.315]
synonym: "cochlear outer hair cell" EXACT []
xref: FMA:62366
is_a: CL:0000202 ! auditory hair cell

[Term]
id: CL:0000602
name: pressoreceptor cell
def: "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." [MESH:A.08.800.050.800.900.700]
is_a: CL:1000082 ! stretch receptor cell

[Term]
id: CL:0000603
name: dikaryon
def: "A fungal cell with two genetically distinct haploid nuclei." [ISBN:08199377X]
is_a: CL:0000227 ! binucleate cell
is_a: CL:0000521 ! fungal cell
is_a: CL:0000600 ! heterokaryon

[Term]
id: CL:0000604
name: retinal rod cell
def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:A.08.663.650.650.670.650]
xref: FMA:67747
is_a: CL:0000287 ! eye photoreceptor cell

[Term]
id: CL:0000605
name: asexual spore
xref: FAO:0000023
is_a: CL:0000522 ! spore

[Term]
id: CL:0000606
name: macroconidium
xref: FAO:0000038
is_a: CL:0000599 ! conidium

[Term]
id: CL:0000607
name: ascospore
def: "A sexual spore produced in an ascus by 'free cell formation'. Has a multilayered spore wall." [ISBN:08199377X]
xref: FAO:0000020
is_a: CL:0000596 ! sexual spore

[Term]
id: CL:0000608
name: zygospore
def: "A resting spore resulting from the conjugation of isogametes or from the fusion of like gametangia." [ISBN:08199377X]
xref: FAO:0000040
is_a: CL:0000522 ! spore

[Term]
id: CL:0000609
name: vestibular hair cell
def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." [MESH:A.08.663.650.250.380]
is_a: CL:0000202 ! auditory hair cell

[Term]
id: CL:0000610
name: plant cell
def: "A cell found in seeded plants." [TAIR:syr]
is_a: CL:0000255 ! eukaryotic cell

[Term]
id: CL:0000611
name: eosinophil progenitor cell
def: "A progenitor cell committed to the eosinophil lineage." [http://www.copewithcytokines.de]
synonym: "CFU-Eo" RELATED []
synonym: "colony forming unit eosinophil" RELATED []
synonym: "eosinophil stem cell" RELATED []
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell

[Term]
id: CL:0000612
name: eosinophilic myelocyte
def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, differentiation of cytoplasmic granules has begun." [GOC:add, ISBN:0721601464]
is_a: CL:0000772 ! immature eosinophil
relationship: develops_from CL:0000833 ! eosinophilic promyelocyte

[Term]
id: CL:0000613
name: basophil progenitor cell
def: "A progenitor cell committed to the basophil lineage." [GOC:add, http://www.copewithcytokines.de]
synonym: "basophilic stem cell" RELATED []
synonym: "CFU-Bas" RELATED []
synonym: "colony forming unit basophil" RELATED []
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell

[Term]
id: CL:0000614
name: basophilic myelocyte
def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, differentiation of cytoplasmic granules has begun." [GOC:add, ISBN:0721601464]
is_a: CL:0000768 ! immature basophil
relationship: develops_from CL:0000830 ! basophilic promyelocyte

[Term]
id: CL:0000615
name: basidiospore
def: "A spore containing one or two haploid nuclei produced, after meiosis, on a basidium." [ISBN:08199377X]
xref: FAO:0000021
is_a: CL:0000596 ! sexual spore

[Term]
id: CL:0000616
name: sporangiospore
def: "A walled spore produced in a sporangium." [ISBN:08199377X]
is_a: CL:0000605 ! asexual spore

[Term]
id: CL:0000617
name: GABAergic neuron
is_a: CL:0000107 ! autonomic neuron

[Term]
id: CL:0000618
name: sheath cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000619
name: support cell (sensu Nematoda)
is_a: CL:0000124 ! glial cell (sensu Nematoda and Protostomia)
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000620
name: zoospore
def: "A sporangiospore that is motile, having flagella." [ISBN:08199377X]
xref: FAO:0000039
is_a: CL:0000616 ! sporangiospore

[Term]
id: CL:0000621
name: fusion competent myoblast
is_a: CL:0000056 ! myoblast

[Term]
id: CL:0000622
name: acinar cell
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000623
name: natural killer cell
def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "large granular lymphocyte" BROAD []
synonym: "NK cell" EXACT []
synonym: "null cell" BROAD []
is_a: CL:0000542 ! lymphocyte
relationship: develops_from CL:0000825 ! pro-NK cell
relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell

[Term]
id: CL:0000624
name: CD4-positive, alpha-beta T cell
def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." [GOC:add, ISBN:0781735149]
synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta T-cell" EXACT []
synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000791 ! mature alpha-beta T cell

[Term]
id: CL:0000625
name: CD8-positive, alpha-beta T cell
def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." [GOC:add, ISBN:0781735149]
synonym: "CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta T-cell" EXACT []
synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000791 ! mature alpha-beta T cell

[Term]
id: CL:0000626
name: olfactory granule cell
def: "Granule cell that is part of the olfactory bulb." [GOC:mah]
is_a: CL:0000120 ! granule cell

[Term]
id: CL:0000627
name: transporting cell
def: "A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances." [TAIR:sr]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000628
name: photosynthetic cell
def: "A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source." [TAIR:sr]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000629
name: storage cell
def: "A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose." [FB:ma]
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000630
name: supportive cell
def: "A cell whose primary function is to support other cell types." [FB:ma]
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000631
name: labyrinth supporting cell
def: "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen." [MESH:A.09.246.631.246.577.543]
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000632
name: ito cell
synonym: "hepatic perisinusoidal cell" EXACT []
synonym: "perisinusoidal cell" EXACT []
xref: FMA:67763
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000633
name: Hensen cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000634
name: Claudius cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000635
name: Deiter's cell
synonym: "phalangeal cell" RELATED []
is_a: CL:0000066 ! epithelial cell
is_a: CL:0005014 ! auditory epithelial support cell

[Term]
id: CL:0000636
name: Muller cell
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000637
name: chromophil cell
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000638
name: acidophil cell
synonym: "alpha cell" EXACT []
is_a: CL:0000637 ! chromophil cell

[Term]
id: CL:0000639
name: basophil cell of anterior lobe of hypophysis
synonym: "beta cell" RELATED []
is_a: CL:0000637 ! chromophil cell

[Term]
id: CL:0000641
name: chromophobe cell
synonym: "chromophobic cell" EXACT []
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000642
name: folliculostellate cell
def: "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones." [JB:jb]
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000643
name: tanycyte
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000644
name: Bergmann glial cell
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000645
name: pituicyte
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000646
name: basal cell
is_a: CL:0000036 ! epithelial fate stem cell

[Term]
id: CL:0000647
name: multinucleated giant cell
def: "A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas." [GOC:add, ISBN:0702022918, ISBN:0702024783]
comment: Role or process: Chronic infection, granulomatous inflammation.
synonym: "foreign body giant cell" EXACT [ISBN:0702022918, ISBN:0702024783]
synonym: "Langerhans giant cell" EXACT [ISBN:0702022918, ISBN:0702024783]
synonym: "macrophage polykaryon" EXACT [ISBN:0702022918, ISBN:0702024783]
synonym: "multinucleate giant cell" EXACT [ISBN:0702022918, ISBN:0702024783]
synonym: "syncytial giant cell" EXACT [ISBN:0702022918, ISBN:0702024783]
is_a: CL:0000766 ! myeloid leukocyte
relationship: develops_from CL:0000235 ! macrophage

[Term]
id: CL:0000648
name: juxtaglomerular cell
xref: FMA:84138
is_a: CL:0000192 ! smooth muscle cell

[Term]
id: CL:0000649
name: prickle cell
is_a: CL:0000312 ! keratinocyte

[Term]
id: CL:0000650
name: mesangial cell
xref: FMA:70972
relationship: develops_from CL:0000134 ! mesenchymal cell

[Term]
id: CL:0000651
name: neck cell
synonym: "mucous neck cell" EXACT []
is_a: CL:0000319 ! mucus secreting cell

[Term]
id: CL:0000652
name: pinealocyte
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000653
name: podocyte
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0000654
name: primary oocyte
xref: FMA:18645
is_a: CL:0000023 ! oocyte

[Term]
id: CL:0000655
name: secondary oocyte
xref: FMA:18646
is_a: CL:0000023 ! oocyte

[Term]
id: CL:0000656
name: primary spermatocyte
is_a: CL:0000017 ! spermatocyte

[Term]
id: CL:0000657
name: secondary spermatocyte
xref: FBbt:00004941
is_a: CL:0000017 ! spermatocyte

[Term]
id: CL:0000658
name: cuticle secreting cell
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000659
name: eggshell secreting cell
is_a: CL:0000327 ! extracellular matrix secreting cell
is_a: CL:0000500 ! follicular epithelial cell

[Term]
id: CL:0000660
name: glycocalyx secreting cell
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000661
name: distal tip cell (sensu Nematoda)
is_a: CL:0000422 ! mitogenic signaling cell

[Term]
id: CL:0000662
name: neuroglioblast (sensu Nematoda)
is_a: CL:0000468 ! neuroglioblast

[Term]
id: CL:0000663
name: valve cell
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000664
name: closable valve cell
is_a: CL:0000185 ! myoepithelial cell
is_a: CL:0000663 ! valve cell

[Term]
id: CL:0000665
name: permanently open valve cell
is_a: CL:0000663 ! valve cell

[Term]
id: CL:0000666
name: fenestrated cell
synonym: "window cell" EXACT []
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0000667
name: collagen secreting cell
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000668
name: parenchymal cell
def: "Typically this is a not distinctly specialized cell with a nucleate protoplast concerned with one or more of the various physiological and biochemical activities in plants. Varies in size, form, and wall structure." [ISBN:0471245208]
is_a: CL:0000063 ! cell by histology
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0000669
name: adventitial cell
synonym: "adventitial reticular cell" EXACT []
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000670
name: primordial germ cell
is_a: CL:0000039 ! germ line cell
is_a: CL:0000219 ! motile cell

[Term]
id: CL:0000671
name: centripetally migrating follicle cell
xref: FBbt:00004906
is_a: CL:0000477 ! follicle cell

[Term]
id: CL:0000672
name: tracheary element
def: "A water conducting cell, tracheid or vessel member." [ISBN:0471245208]
is_a: CL:0000610 ! plant cell
is_a: CL:0000627 ! transporting cell

[Term]
id: CL:0000673
name: Kenyon cell
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000674
name: interfollicle cell
synonym: "stalk cell" EXACT []
xref: FBbt:00004910
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0000675
name: female gamete
is_a: CL:0000300 ! gamete

[Term]
id: CL:0000676
name: cap cell
is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000677
name: gut absorptive cell
def: "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." [JB:jb]
is_a: CL:0000212 ! absorptive cell

[Term]
id: CL:0000678
name: commisural neuron
is_a: CL:0000372 ! tormogen cell

[Term]
id: CL:0000679
name: glutamatergic neuron
is_a: CL:0000107 ! autonomic neuron

[Term]
id: CL:0000680
name: muscle precursor cell
relationship: develops_from CL:0000222 ! mesodermal cell

[Term]
id: CL:0000681
name: radial glial cell
def: "A transient cell present only in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [GOC:dph]
is_a: CL:0000337 ! neuroblast (sensu Vertebrata)
relationship: develops_from CL:0000710 ! neuroepithelial cell

[Term]
id: CL:0000682
name: M cell
def: "An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes." [JB:jb]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000473 ! defensive cell
is_a: CL:0000627 ! transporting cell

[Term]
id: CL:0000683
name: ependymoglial cell
def: "A cell that transports hormones from neurosecretory cells." [JB:jb]
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:0000684
name: littoral cell of liver
is_a: CL:0000077 ! mesothelial cell

[Term]
id: CL:0000685
name: meristematic cell
def: "A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall." [PO:0004010]
is_a: CL:0000610 ! plant cell
is_a: CL:0000723 ! somatic stem cell

[Term]
id: CL:0000686
name: cerebrospinal fluid secreting cell
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0000151 ! secretory cell
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0000687
name: R1 photoreceptor cell
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000688
name: perijunctional fibroblast
def: "A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina." [JB:jb]
is_a: CL:0000057 ! fibroblast
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000689
name: myoendocrine cell
def: "A cell with both myofibrils and secretory granules." [JB:jb]
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000690
name: R2 photoreceptor cell
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000691
name: stellate interneuron
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000692
name: terminal Schwann cell
def: "A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse." [JB:jb]
is_a: CL:0000630 ! supportive cell
relationship: develops_from CL:0000125 ! glial cell

[Term]
id: CL:0000693
name: neuroglioform cell
def: "A stellate interneuron having 7-10 dendrites that may branch." [JB:jb]
synonym: "spiderweb cell" EXACT []
is_a: CL:0000691 ! stellate interneuron

[Term]
id: CL:0000694
name: R3 photoreceptor cell
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000695
name: Cajal-Retzius cell
def: "One of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [PMID:10600995, PMID:9728912]
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000696
name: pp cell
def: "A cell that stores pancreatic polypeptides." [JB:jb]
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000697
name: R4 photoreceptor cell
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000698
name: paraganglial cell
is_obsolete: true

[Term]
id: CL:0000699
name: paraganglial type 1 cell
is_a: CL:0000165 ! neuroendocrine cell

[Term]
id: CL:0000700
name: dopaminergic neuron
def: "A neuron that releases dopamine as a neurotransmitter." [CL:dhill]
is_a: CL:0000107 ! autonomic neuron

[Term]
id: CL:0000701
name: paraganglia type 2 cell
def: "Supports paraganglial type 1 cell." [JB:jb]
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000702
name: R5 photoreceptor cell
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000703
name: sustentacular cell
def: "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." [JB:jb]
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000704
name: endothelial tip cell
def: "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." [PMID:15376331]
is_a: CL:0000071 ! blood vessel endothelial cell

[Term]
id: CL:0000705
name: R6 photoreceptor cell
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000706
name: choroid plexus epithelial cell
def: "Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord." [GOC:add, JB:jb, PMID:9550134]
is_a: CL:0000065 ! ependymal cell
is_a: CL:0000627 ! transporting cell

[Term]
id: CL:0000707
name: R7 photoreceptor cell
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000494 ! UV sensitive photoreceptor cell

[Term]
id: CL:0000708
name: leptomeningeal  cell
def: "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." [JB:jb]
synonym: "leptomemingeal cell" RELATED []
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000709
name: R8 photoreceptor cell
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0000488 ! visible light photoreceptor cell

[Term]
id: CL:0000710
name: neuroepithelial cell
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000711
name: cumulus cell
is_a: CL:0000154 ! protein secreting cell
relationship: develops_from CL:0000501 ! granulosa cell

[Term]
id: CL:0000712
name: stratum granulosum cell
is_a: CL:0000362 ! epidermal cell

[Term]
id: CL:0000713
name: corona radiata cell
is_a: CL:0000711 ! cumulus cell

[Term]
id: CL:0000715
name: embryonic crystal cell
is_a: CL:0000392 ! crystal cell
is_a: CL:0000736 ! embryonic gland hemocyte

[Term]
id: CL:0000716
name: lymph gland crystal cell
is_a: CL:0000392 ! crystal cell
is_a: CL:0000735 ! lymph gland hemocyte

[Term]
id: CL:0000717
name: fusimotor neuron
def: "A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons." [PMID:15582775]
is_a: CL:0000100 ! motor neuron

[Term]
id: CL:0000718
name: cone cell (sensu Endopterygota)
is_a: CL:0000306 ! crystallin accumulating cell

[Term]
id: CL:0000719
name: posterior cone cell (sensu Endopterygota)
is_a: CL:0000718 ! cone cell (sensu Endopterygota)

[Term]
id: CL:0000720
name: anterior cone cell (sensu Endopterygota)
is_a: CL:0000718 ! cone cell (sensu Endopterygota)

[Term]
id: CL:0000721
name: equatorial cone cell (sensu Endopterygota)
is_a: CL:0000718 ! cone cell (sensu Endopterygota)

[Term]
id: CL:0000722
name: cystoblast
is_a: CL:0000548 ! animal cell
is_a: CL:0000586 ! germ cell

[Term]
id: CL:0000723
name: somatic stem cell
def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103]
is_a: CL:0000034 ! stem cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000724
name: heterocyst
def: " A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." [MA:ma]
is_a: CL:0000520 ! prokaryotic cell
is_a: CL:0000725 ! nitrogen fixing cell

[Term]
id: CL:0000725
name: nitrogen fixing cell
is_a: CL:0000144 ! cell by function

[Term]
id: CL:0000726
name: chlamydospore
def: "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." [ISBN:085199377X]
is_a: CL:0000605 ! asexual spore

[Term]
id: CL:0000727
name: primary pigment cell
is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000728
name: secondary pigment cell
is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000729
name: tertiary pigment cell
is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0000730
name: leading edge cell
def: "A cell at the front of a migrating epithelial sheet." [MA:ma]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000731
name: urothelial cell
def: "A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [MA:ma]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000732
name: amoeboid cell
is_a: CL:0000219 ! motile cell

[Term]
id: CL:0000733
name: lymph gland plasmatocyte
is_a: CL:0000394 ! plasmatocyte
is_a: CL:0000735 ! lymph gland hemocyte

[Term]
id: CL:0000734
name: embryonic gland plasmatocyte
is_a: CL:0000394 ! plasmatocyte
is_a: CL:0000736 ! embryonic gland hemocyte

[Term]
id: CL:0000735
name: lymph gland hemocyte
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000736
name: embryonic gland hemocyte
is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia)

[Term]
id: CL:0000737
name: striated muscle cell
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0000738
name: leukocyte
def: "A nucleated cell of the myeloid or lymphoid lineages, found in blood or other tissue." [GOC:add]
synonym: "immune cell" EXACT []
synonym: "leucocyte" EXACT []
synonym: "white blood cell" EXACT []
is_a: CL:0000988 ! hematopoietic cell
relationship: develops_from CL:0000037 ! hematopoietic stem cell

[Term]
id: CL:0000740
name: retinal ganglion cell
def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [CL:dph]
synonym: "gangliocyte" EXACT []
synonym: "ganglion cell of retina" EXACT []
synonym: "RGC" EXACT []
xref: FMA:67765
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)

[Term]
id: CL:0000741
name: spinal accessory motor neuron
def: "A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord." [PMID:16267219]
synonym: "SACMN" EXACT []
is_a: CL:0000100 ! motor neuron

[Term]
id: CL:0000742
name: periarticular chondrocyte
def: "A round chondrocyte that first differentiates in the late embryonic growth plate of bone." [PMID:15951842]
is_a: CL:0000138 ! chondrocyte

[Term]
id: CL:0000743
name: hypertrophic chondrocyte
def: "A terminally differentiated chondrocyte that differentiates in the late embryonic growth plate of bone." [PMID:15951842]
is_a: CL:0000138 ! chondrocyte

[Term]
id: CL:0000744
name: columnar chondrocyte
def: "A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate." [PMID:15951842]
is_a: CL:0000138 ! chondrocyte

[Term]
id: CL:0000745
name: horizontal cell
def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [ISBN:0195088433]
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000746
name: cardiac muscle cell
synonym: "cardiac myocyte" EXACT []
synonym: "cardiomyocyte" EXACT []
xref: FMA:14067
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0000747
name: cyanophore
def: "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." [SANBI:mhl]
synonym: "blue chromatophore" RELATED []
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005005 ! cyanoblast

[Term]
id: CL:0000748
name: retinal bipolar neuron
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [PMID:14689473]
is_a: CL:0000103 ! bipolar neuron

[Term]
id: CL:0000749
name: ON-bipolar cell
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473]
is_a: CL:0000748 ! retinal bipolar neuron

[Term]
id: CL:0000750
name: OFF-bipolar cell
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells hyperpolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473]
is_a: CL:0000748 ! retinal bipolar neuron

[Term]
id: CL:0000751
name: rod bipolar cell
def: "A bipolar neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer." [PMID:14689473]
is_a: CL:0000748 ! retinal bipolar neuron
is_a: CL:0000749 ! ON-bipolar cell

[Term]
id: CL:0000752
name: cone retinal bipolar cell
def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." [PMID:14689473]
is_a: CL:0000748 ! retinal bipolar neuron

[Term]
id: CL:0000753
name: type 1 cone bipolar cell (sensu Mus)
def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities." [PMID:14689473]
synonym: "DB1 cone bipolar cell" EXACT []
is_a: CL:0000750 ! OFF-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000754
name: type 2 cone bipolar cell (sensu Mus)
def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1." [PMID:14689473]
synonym: "FMB cone bipolar cell" EXACT []
is_a: CL:0000750 ! OFF-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000755
name: type 3 cone bipolar cell (sensu Mus)
def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer." [PMID:14689473]
synonym: "DB2 cone bipolar cell" EXACT []
is_a: CL:0000750 ! OFF-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000756
name: type 4 cone bipolar cell (sensu Mus)
def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer." [PMID:14689473]
synonym: "DB3 cone bipolar cell" EXACT []
is_a: CL:0000750 ! OFF-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000757
name: type 5 cone bipolar cell (sensu Mus)
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches." [PMID:14689473]
synonym: "DB4 cone bipolar cell" EXACT []
is_a: CL:0000749 ! ON-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000758
name: type 6 cone bipolar cell (sensu Mus)
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4." [PMID:14689473]
synonym: "DB5 cone bipolar cell" EXACT []
is_a: CL:0000749 ! ON-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000759
name: type 7 cone bipolar cell (sensu Mus)
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer." [PMID:14689473]
synonym: "IMB cone bipolar cell" EXACT []
is_a: CL:0000749 ! ON-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000760
name: type 8 cone bipolar cell (sensu Mus)
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer." [PMID:14689473]
synonym: "DB6 cone bipolar cell" EXACT []
is_a: CL:0000749 ! ON-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000761
name: type 9 cone bipolar cell (sensu Mus)
def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer." [PMID:14689473]
synonym: "BB cone bipolar cell" EXACT []
is_a: CL:0000749 ! ON-bipolar cell
is_a: CL:0000752 ! cone retinal bipolar cell

[Term]
id: CL:0000762
name: thrombocyte
def: "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." [GOC:add]
comment: Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals.
is_a: CL:0000081 ! blood cell
is_a: CL:0000763 ! myeloid cell
relationship: develops_from CL:0000828 ! thromboblast

[Term]
id: CL:0000763
name: myeloid cell
def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add]
is_a: CL:0000988 ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: develops_from CL:0000049 ! common myeloid progenitor

[Term]
id: CL:0000764
name: erythroid lineage cell
def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add]
is_a: CL:0000763 ! myeloid cell

[Term]
id: CL:0000765
name: erythroblast
def: "A nucleated precursor of an erythrocyte." [GOC:add, ISBN:0721601464]
synonym: "normoblast" EXACT []
is_a: CL:0000764 ! erythroid lineage cell

[Term]
id: CL:0000766
name: myeloid leukocyte
def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add]
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: develops_from CL:0000049 ! common myeloid progenitor

[Term]
id: CL:0000767
name: basophil
def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [GOC:add, ISBN:0721601464]
comment: This term covers both immature and mature forms of basophils.
synonym: "basophilic leucocyte" EXACT []
synonym: "basophilic leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
is_a: CL:0000094 ! granulocyte

[Term]
id: CL:0000768
name: immature basophil
def: "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking. A basophil is granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [GOC:add, ISBN:0721601464]
synonym: "immature basophilic leucocyte" EXACT []
synonym: "immature basophilic leukocyte" EXACT []
is_a: CL:0000767 ! basophil
relationship: develops_from CL:0000830 ! basophilic promyelocyte

[Term]
id: CL:0000769
name: basophilic metamyelocyte
def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil." [ISBN:0721601464]
is_a: CL:0000768 ! immature basophil
relationship: develops_from CL:0000614 ! basophilic myelocyte

[Term]
id: CL:0000770
name: band form basophil
def: "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, ISBN:0721601464]
is_a: CL:0000768 ! immature basophil
relationship: develops_from CL:0000769 ! basophilic metamyelocyte

[Term]
id: CL:0000771
name: eosinophil
def: "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin." [GOC:add, ISBN:0721601464]
synonym: "eosinocyte" EXACT []
synonym: "eosinophilic leucocyte" EXACT []
synonym: "eosinophilic leukocyte" EXACT []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
is_a: CL:0000094 ! granulocyte

[Term]
id: CL:0000772
name: immature eosinophil
def: "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking. An eosinophil is a granulocyte that in its mature form has a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin." [GOC:add, ISBN:0721601464]
synonym: "immature eosinocyte" EXACT []
synonym: "immature eosinophilic leucocyte" EXACT []
synonym: "immature eosinophilic leukocyte" EXACT []
is_a: CL:0000771 ! eosinophil
relationship: develops_from CL:0000833 ! eosinophilic promyelocyte

[Term]
id: CL:0000773
name: eosinophilic metamyelocyte
def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil." [GOC:add, ISBN:0721601464]
is_a: CL:0000772 ! immature eosinophil
relationship: develops_from CL:0000612 ! eosinophilic myelocyte

[Term]
id: CL:0000774
name: band form eosinophil
def: "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, ISBN:0721601464]
is_a: CL:0000772 ! immature eosinophil
relationship: develops_from CL:0000773 ! eosinophilic metamyelocyte

[Term]
id: CL:0000775
name: neutrophil
def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [GOC:add, ISBN:0721601464]
synonym: "neutrocyte" EXACT []
synonym: "neutrophil leucocyte" EXACT []
synonym: "neutrophil leukocyte" EXACT []
synonym: "neutrophilic leucocyte" EXACT []
synonym: "neutrophilic leukocyte" EXACT []
synonym: "PMN" BROAD []
synonym: "poly" BROAD []
synonym: "polymorphonuclear leucocyte" BROAD []
synonym: "polymorphonuclear leukocyte" BROAD []
synonym: "polymorphonuclear neutrophil" BROAD []
synonym: "polynuclear neutrophilic leucocyte" BROAD []
synonym: "polynuclear neutrophilic leukocyte" BROAD []
is_a: CL:0000094 ! granulocyte

[Term]
id: CL:0000776
name: immature neutrophil
def: "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking. A neutrophil is a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [GOC:add, ISBN:0721601464]
synonym: "immatuer neutrophilic leukocyte" EXACT []
synonym: "immature neutrocyte" EXACT []
synonym: "immature neutrophil leucocyte" EXACT []
synonym: "immature neutrophil leukocyte" EXACT []
synonym: "immature neutrophilic leucocyte" EXACT []
is_a: CL:0000775 ! neutrophil
relationship: develops_from CL:0000564 ! neutrophilic promyelocyte

[Term]
id: CL:0000777
name: mesangial phagocyte
def: "A tissue-resident macrophage of the renal glomerular mesangium." [GOC:add, ISBN:0702022918, ISBN:3540536663, PMID:1600140, PMID:16146841]
synonym: "mesangial cell" BROAD []
is_a: CL:0000864 ! tissue-resident macrophage

[Term]
id: CL:0000778
name: mononuclear osteoclast
def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452]
comment: Morphology: mononuclear, highly vesicular.
is_a: CL:0000092 ! osteoclast

[Term]
id: CL:0000779
name: multinuclear osteoclast
def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:9415452]
comment: Morphology: multinucleated, highly vesicular.
synonym: "multinucleated osteoclast" EXACT []
is_a: CL:0000092 ! osteoclast
relationship: develops_from CL:0000778 ! mononuclear osteoclast

[Term]
id: CL:0000780
name: multinuclear odontoclast
def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452]
comment: Morphology: multinucleated, highly vesicular; location: roots of decidious (milk) teeth.
synonym: "multinucleated odontoclast" EXACT []
is_a: CL:0000588 ! odontoclast
is_a: CL:0000779 ! multinuclear osteoclast
relationship: develops_from CL:0000781 ! mononuclear odontoclast

[Term]
id: CL:0000781
name: mononuclear odontoclast
def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452]
comment: Morphology: Mononuclear, highly vesicular; location: roots of decidious (milk) teeth.
is_a: CL:0000588 ! odontoclast
is_a: CL:0000778 ! mononuclear osteoclast

[Term]
id: CL:0000782
name: myeloid dendritic cell
def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:9521319]
synonym: "DC1" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "veiled cell" BROAD []
is_a: CL:0000990 ! conventional dendritic cell
relationship: develops_from CL:0000576 ! monocyte

[Term]
id: CL:0000783
name: multinucleated phagocyte
def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add]
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)

[Term]
id: CL:0000784
name: plasmacytoid dendritic cell
def: "A dendritic cell type of distinct morphology, localization, and surface marker expression from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." [GOC:add, PMID:15549123, PMID:15596797]
synonym: "DC2" EXACT []
synonym: "interferon-producing cell" EXACT []
synonym: "IPC" EXACT []
synonym: "lymphoid dendritic cell" EXACT []
synonym: "pDC" EXACT []
synonym: "plasmacytoid monocyte" EXACT []
synonym: "plasmacytoid T cell" EXACT []
synonym: "T-associated plasma cell" EXACT []
is_a: CL:0000451 ! dendritic cell
relationship: develops_from CL:0000037 ! hematopoietic stem cell

[Term]
id: CL:0000785
name: mature B cell
def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." [GOC:add, ISBN:0781735149]
synonym: "mature B lymphocyte" EXACT []
synonym: "mature B-cell" EXACT []
synonym: "mature B-lymphocyte" EXACT []
is_a: CL:0000236 ! B cell
relationship: develops_from CL:0000816 ! immature B cell

[Term]
id: CL:0000786
name: plasma cell
def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, ISBN:0721601464, ISBN:0781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003. 781735149"]
synonym: "plasmacyte" EXACT []
is_a: CL:0000946 ! antibody secreting cell
relationship: develops_from CL:0000980 ! plasmablast

[Term]
id: CL:0000787
name: memory B cell
def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." [GO_REF:0000031, GOC:add, GOC:rhs, ISBN:0781735149]
synonym: "memory B lymphocyte" EXACT []
synonym: "memory B-cell" EXACT []
synonym: "memory B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell

[Term]
id: CL:0000788
name: naive B cell
def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD27-negative, and CD38-negative, and that has not yet been activated by antigen in the periphery." [GO_REF:0000031, GOC:add, GOC:rhs, IBSN:0781765196]
synonym: "naive B lymphocyte" EXACT []
synonym: "naive B-cell" EXACT []
synonym: "naive B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell
relationship: develops_from CL:0000818 ! transitional stage B cell

[Term]
id: CL:0000789
name: alpha-beta T cell
def: "A T cell that expresses an alpha-beta T cell receptor complex." [GOC:add, ISBN:0781735149]
synonym: "alpha-beta T lymphocyte" EXACT []
synonym: "alpha-beta T-cell" EXACT []
synonym: "alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000084 ! T cell

[Term]
id: CL:0000790
name: immature alpha-beta T cell
def: "An alpha-beta T cell that has an immature phenotype." [GOC:add, ISBN:0781735149]
synonym: "immature alpha-beta T lymphocyte" EXACT []
synonym: "immature alpha-beta T-cell" EXACT []
synonym: "immature alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000789 ! alpha-beta T cell

[Term]
id: CL:0000791
name: mature alpha-beta T cell
def: "A alpha-beta T cell that has a mature phenotype." [GOC:add, ISBN:0781735149]
synonym: "mature alpha-beta T lymphocyte" EXACT []
synonym: "mature alpha-beta T-cell" EXACT []
synonym: "mature alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000789 ! alpha-beta T cell

[Term]
id: CL:0000792
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell
def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, ISBN:0781735149]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT []
synonym: "suppressor T cell" BROAD []
synonym: "suppressor T lymphocyte" BROAD []
synonym: "suppressor T-cell" BROAD []
synonym: "suppressor T-lymphocyte" BROAD []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000815 ! regulatory T cell

[Term]
id: CL:0000793
name: CD4-positive, alpha-beta intraepithelial T cell
def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." [GOC:add, ISBN:0781735149]
synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000797 ! alpha-beta intraepithelial T cell
relationship: develops_from CL:0000810 ! CD4-positive, alpha-beta thymocyte

[Term]
id: CL:0000794
name: CD8-positive, alpha-beta cytotoxic T cell
def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." [GO_REF:0000031, GOC:add, GOC:pam, ISBN:0781735149]
comment: Note that while T cels of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo.
synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-cell" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte" EXACT []
synonym: "cytotoxic T cell" BROAD []
synonym: "cytotoxic T lymphocyte" BROAD []
synonym: "cytotoxic T-cell" BROAD []
synonym: "cytotoxic T-lymphocyte" BROAD []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000910 ! cytotoxic T cell
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell

[Term]
id: CL:0000795
name: CD8-positive, alpha-beta regulatory T cell
def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, ISBN:0781735149]
synonym: "CD8-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte" EXACT []
synonym: "suppressor T cell" BROAD []
synonym: "suppressor T lymphocyte" BROAD []
synonym: "suppressor T-cell" BROAD []
synonym: "suppressor T-lymphocyte" BROAD []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000815 ! regulatory T cell

[Term]
id: CL:0000796
name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell
def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, ISBN:0781735149]
synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000797 ! alpha-beta intraepithelial T cell

[Term]
id: CL:0000797
name: alpha-beta intraepithelial T cell
def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, ISBN:0781735149]
synonym: "alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "alpha-beta intraepithelial T-cell" EXACT []
synonym: "alpha-beta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000791 ! mature alpha-beta T cell

[Term]
id: CL:0000798
name: gamma-delta T cell
def: "A T cell that expresses a gamma-delta T cell receptor complex." [GOC:add, ISBN:0781735149]
comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways.
synonym: "gamma-delta T lymphocyte" EXACT []
synonym: "gamma-delta T-cell" EXACT []
synonym: "gamma-delta T-lymphocyte" EXACT []
is_a: CL:0000084 ! T cell

[Term]
id: CL:0000799
name: immature gamma-delta T cell
def: "A gamma-delta T cell that has an immature phenotype." [GOC:add, ISBN:0781735149]
comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways.
synonym: "immature gamma-delta T lymphocyte" EXACT []
synonym: "immature gamma-delta T-cell" EXACT []
synonym: "immature gamma-delta T-lymphocyte" EXACT []
is_a: CL:0000798 ! gamma-delta T cell
relationship: develops_from CL:0000807 ! DN3 thymocyte

[Term]
id: CL:0000800
name: mature gamma-delta T cell
def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." [GOC:add, ISBN:0781735149]
synonym: "mature gamma-delta T lymphocyte" EXACT []
synonym: "mature gamma-delta T-cell" EXACT []
synonym: "mature gamma-delta T-lymphocyte" EXACT []
is_a: CL:0000798 ! gamma-delta T cell
relationship: develops_from CL:0000799 ! immature gamma-delta T cell

[Term]
id: CL:0000801
name: gamma-delta intraepithelial T cell
def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, ISBN:0781735149]
synonym: "gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "gamma-delta intraepithelial T-cell" EXACT []
synonym: "gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000800 ! mature gamma-delta T cell

[Term]
id: CL:0000802
name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell
def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, ISBN:0781735149]
synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000801 ! gamma-delta intraepithelial T cell

[Term]
id: CL:0000803
name: CD4-negative CD8-negative gamma-delta intraepithelial T cell
def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, ISBN:0781735149]
synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT []
synonym: "IEL" BROAD []
synonym: "intraepithelial lymphocyte" BROAD []
is_a: CL:0000801 ! gamma-delta intraepithelial T cell

[Term]
id: CL:0000805
name: immature single positive thymocyte
def: "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149]
comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages.
synonym: "immature single positive T cell" EXACT []
synonym: "immature single positive T lymphocyte" EXACT []
synonym: "immature single positive T-lymphocyte" EXACT []
synonym: "ISP" EXACT []
is_a: CL:0000893 ! thymocyte
relationship: develops_from CL:0000808 ! DN4 thymocyte

[Term]
id: CL:0000806
name: DN2 thymocyte
def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149]
comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains.
synonym: "DN2 alpha-beta immature T lymphocyte" EXACT []
synonym: "DN2 alpha-beta immature T-cell" EXACT []
synonym: "DN2 alpha-beta immature T-lymphocyte" EXACT []
synonym: "DN2 cell" EXACT []
synonym: "DN2 immature T cell" EXACT []
synonym: "TN2 cell" EXACT []
synonym: "TN2 thymocyte" EXACT []
is_a: CL:0000893 ! thymocyte
relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell

[Term]
id: CL:0000807
name: DN3 thymocyte
def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [GO_REF:0000031, GOC:add, ISBN:0781735149]
synonym: "DN3 alpha-beta immature T lymphocyte" EXACT []
synonym: "DN3 alpha-beta immature T-cell" EXACT []
synonym: "DN3 alpha-beta immature T-lymphocyte" EXACT []
synonym: "DN3 cell" EXACT []
synonym: "DN3 immature T cell" EXACT []
synonym: "TN3 cell" EXACT []
synonym: "TN3 thymocyte" EXACT []
is_a: CL:0000790 ! immature alpha-beta T cell
is_a: CL:0000893 ! thymocyte
relationship: develops_from CL:0000806 ! DN2 thymocyte

[Term]
id: CL:0000808
name: DN4 thymocyte
def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149]
comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain.
synonym: "DN4 alpha-beta immature T lymphocyte" EXACT []
synonym: "DN4 alpha-beta immature T-lymphocyte" EXACT []
synonym: "DN4 cell" EXACT []
synonym: "DN4 immature T cell" EXACT []
synonym: "DN4 immature T-cell" EXACT []
is_a: CL:0000790 ! immature alpha-beta T cell
is_a: CL:0000893 ! thymocyte
relationship: develops_from CL:0000807 ! DN3 thymocyte

[Term]
id: CL:0000809
name: double-positive, alpha-beta thymocyte
def: "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." [GO_REF:0000031, GOC:add, ISBN:0781735149]
comment: Thymocytes of this stage are undergoing positive and negative selection.
synonym: "double-positive, alpha-beta immature T lymphocyte" EXACT []
synonym: "DP cell" EXACT []
synonym: "DP thymocyte" EXACT []
is_a: CL:0000790 ! immature alpha-beta T cell
relationship: develops_from CL:0000805 ! immature single positive thymocyte

[Term]
id: CL:0000810
name: CD4-positive, alpha-beta thymocyte
def: "An immature alpha-beta T cell that is located in the thymus and expressing the CD4 coreceptor." [GO_REF:0000031, GOC:add, ISBN:0781735149]
synonym: "CD4-positive, alpha-beta immature T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta immature T-cell" EXACT []
synonym: "CD4-positive, alpha-beta immature T-lymphocyte" EXACT []
synonym: "SP CD4 cell" EXACT []
is_a: CL:0000790 ! immature alpha-beta T cell
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte

[Term]
id: CL:0000811
name: CD8-positive, alpha-beta thymocyte
def: "An immature alpha-beta T cell that is located in the thymus and expressing the CD8 coreceptor." [GO_REF:0000031, GOC:add, ISBN:0781735149]
synonym: "CD8-positive, alpha-beta immature T cell" RELATED []
synonym: "CD8-positive, alpha-beta immature T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta immature T-cell" EXACT []
synonym: "CD8-positive, alpha-beta immature T-lymphocyte" EXACT []
synonym: "SP CD8 cell" EXACT []
is_a: CL:0000790 ! immature alpha-beta T cell
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte

[Term]
id: CL:0000813
name: memory T cell
def: "A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." [GO_REF:0000031, GOC:add, GOC:pam, ISBN:0781735149]
synonym: "memory T lymphocyte" EXACT []
synonym: "memory T-cell" EXACT []
synonym: "memory T-lymphocyte" EXACT []
is_a: CL:0000084 ! T cell

[Term]
id: CL:0000814
name: mature NK T cell
def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." [GOC:add, ISBN:0781735149]
synonym: "mature natural killer T cell" EXACT []
synonym: "mature natural killer T lymphocyte" EXACT []
synonym: "mature natural killer T-cell" EXACT []
synonym: "mature natural killer T-lymphocyte" EXACT []
synonym: "mature NK T lymphocyte" EXACT []
synonym: "mature NK T-cell" EXACT []
synonym: "mature NK T-lymphocyte" EXACT []
synonym: "mature NKT cell" EXACT []
is_a: CL:0000791 ! mature alpha-beta T cell
relationship: develops_from CL:0000914 ! immature NK T cell

[Term]
id: CL:0000815
name: regulatory T cell
def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add]
comment: This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta.
synonym: "regulatory T cell" EXACT []
synonym: "regulatory T lymphocyte" EXACT []
synonym: "regulatory T-cell" EXACT []
synonym: "regulatory T-lymphocyte" EXACT []
synonym: "suppressor T cell" BROAD []
synonym: "suppressor T lymphocyte" BROAD []
synonym: "suppressor T-cell" BROAD []
synonym: "suppressor T-lymphocyte" BROAD []
is_a: CL:0000084 ! T cell

[Term]
id: CL:0000816
name: immature B cell
def: "An immature B cell is a precursor B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." [GO_REF:0000031, GOC:add, GOC:rhs, ISBN:0781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."]
synonym: "immature B lymphocyte" EXACT []
synonym: "immature B-cell" EXACT []
synonym: "immature B-lymphocyte" EXACT []
synonym: "newly formed B Cell" EXACT [IBSN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."]
is_a: CL:0000817 ! precursor B cell
relationship: develops_from CL:0000826 ! pro-B cell

[Term]
id: CL:0000817
name: precursor B cell
def: "A precursor B cell is a B cell with the phenotype CD10-positive (P08473/NEP_HUMAN; PIRSF001194)." [GO_REF:0000031, GOC:rhs]
synonym: "pre-B cell" EXACT []
is_a: CL:0000236 ! B cell

[Term]
id: CL:0000818
name: transitional stage B cell
def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12810111]
synonym: "T1 B cell" NARROW []
synonym: "T2 B cell" NARROW []
synonym: "T3 B cell" NARROW []
synonym: "transitional stage B lymphocyte" EXACT []
synonym: "transitional stage B-cell" EXACT []
synonym: "transitional stage B-lymphocyte" EXACT []
is_a: CL:0000236 ! B cell

[Term]
id: CL:0000819
name: B-1 B cell
def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." [GO_REF:0000031, GOC:add, PMID:11861604]
synonym: "B-1 B lymphocyte" EXACT []
synonym: "B-1 B-cell" EXACT []
synonym: "B-1 B-lymphocyte" EXACT []
is_a: CL:0000785 ! mature B cell

[Term]
id: CL:0000820
name: B-1a B cell
def: "A B-1 B cell that has the phenotype CD5-positive." [GOC:add, PMID:11861604]
synonym: "B-1a B lymphocyte" EXACT []
synonym: "B-1a B-cell" EXACT []
synonym: "B-1a B-lymphocyte" EXACT []
is_a: CL:0000819 ! B-1 B cell

[Term]
id: CL:0000821
name: B-1b B cell
def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." [GOC:add, PMID:11861604]
synonym: "B-1b B lymphocyte" EXACT []
synonym: "B-1b B-cell" EXACT []
synonym: "B-1b B-lymphocyte" EXACT []
is_a: CL:0000819 ! B-1 B cell

[Term]
id: CL:0000822
name: B-2 B cell
def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." [GOC:add, ISBN:0781735149, PMID:11861604]
synonym: "B-0 B cell" RELATED []
synonym: "B-2 B lymphocyte" EXACT []
synonym: "B-2 B-cell" EXACT []
synonym: "B-2 B-lymphocyte" EXACT []
synonym: "follicular B cell" RELATED []
is_a: CL:0000785 ! mature B cell

[Term]
id: CL:0000823
name: immature natural killer cell
def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD117-positive, CD122-positive, and CD161-positive, and expresses additional natural killer cell receptors (NKR)." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618]
comment: In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules.
synonym: "immature NK cell" EXACT []
synonym: "p-NK" RELATED [PMID:12457618]
is_a: CL:0000623 ! natural killer cell
relationship: develops_from CL:0000937 ! pre-natural killer cell

[Term]
id: CL:0000824
name: mature natural killer cell
def: "A natural killer cell that is developmentally mature, has the phenotype CD16-positive, and expresses a variety of inhibitory and activating receptors that recognize NHC class I and other stress related molecules." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:14685782]
synonym: "LAK cell" BROAD [PMID:14685782]
synonym: "lymphokine activated killer cell" BROAD [PMID:14685782]
synonym: "mature NK cell" EXACT []
is_a: CL:0000623 ! natural killer cell
relationship: develops_from CL:0000823 ! immature natural killer cell

[Term]
id: CL:0000825
name: pro-NK cell
def: "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11532393, PMID:12457618, PMID:15032583, PMID:15766674]
synonym: "natural killer cell progenitor" EXACT []
synonym: "NKP" EXACT [PMID:12457618, PMID:15032583, PMID:15766674]
synonym: "null cell" RELATED [PMID:11532393]
synonym: "preNK cell" RELATED [PMID:11532393]
synonym: "pro-natural killer cell" EXACT []
is_a: CL:0000838 ! lymphoid progenitor cell
relationship: develops_from CL:0000051 ! common lymphoid progenitor

[Term]
id: CL:0000826
name: pro-B cell
def: "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." [GOC:add, ISBN:0781735149]
synonym: "pro-B lymphocyte" EXACT []
synonym: "pro-B-cell" EXACT []
synonym: "pro-B-lymphocyte" EXACT []
synonym: "progenitor B cell" EXACT []
is_a: CL:0000838 ! lymphoid progenitor cell
relationship: develops_from CL:0000051 ! common lymphoid progenitor

[Term]
id: CL:0000827
name: pro-T cell
def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149]
synonym: "DN1 cell" NARROW []
synonym: "DN1 thymocyte" NARROW []
synonym: "pro-T lymphocyte" EXACT []
synonym: "progenitor T cell" EXACT []
synonym: "TN1 cell" NARROW []
is_a: CL:0000838 ! lymphoid progenitor cell
relationship: develops_from CL:0000051 ! common lymphoid progenitor

[Term]
id: CL:0000828
name: thromboblast
def: "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." [GOC:add]
comment: Note that this is a non-mammalian cell type.
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000050 ! megakaryocyte erythroid progenitor cell

[Term]
id: CL:0000829
name: basophilic myeloblast
def: "A myeloblast committed to the basophil lineage. A myeloblast is the most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, and a nongranular basophilic cytoplasm." [GOC:add, ISBN:0721601464]
is_a: CL:0000835 ! myeloblast
relationship: develops_from CL:0000613 ! basophil progenitor cell

[Term]
id: CL:0000830
name: basophilic promyelocyte
def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, and containing a few, as yet undifferentiated, cytoplasmic granules." [GOC:add, ISBN:0721601464]
is_a: CL:0000836 ! promyelocyte
relationship: develops_from CL:0000829 ! basophilic myeloblast

[Term]
id: CL:0000831
name: mast cell progenitor
def: "A progenitor cell of the mast cell lineage." [GOC:add, http://www.copewithcytokines.de, PMID:16006518, PMID:16330751, PMID:8629001, PMID:9354811]
synonym: "CFU-Mast " RELATED []
synonym: "CFU-MC" RELATED []
synonym: "colony forming unit mast cell" RELATED []
synonym: "MCP" EXACT []
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell

[Term]
id: CL:0000832
name: eosinophilic myeloblast
def: "A myeloblast committed to the eosinophil lineage. A myeloblast is the most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, and a nongranular basophilic cytoplasm." [GOC:add, ISBN:0721601464]
is_a: CL:0000835 ! myeloblast
relationship: develops_from CL:0000611 ! eosinophil progenitor cell

[Term]
id: CL:0000833
name: eosinophilic promyelocyte
def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, and containing a few, as yet undifferentiated, cytoplasmic granules." [GOC:add, ISBN:0721601464]
is_a: CL:0000836 ! promyelocyte
relationship: develops_from CL:0000832 ! eosinophilic myeloblast

[Term]
id: CL:0000834
name: neutrophil progenitor cell
def: "A progenitor cell of the neutrophil lineage." [GOC:add, ISBN:0721601464]
synonym: "neutrophil stem cell" RELATED []
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell

[Term]
id: CL:0000835
name: myeloblast
def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, and a nongranular basophilic cytoplasm." [GOC:add, ISBN:0721601464]
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell

[Term]
id: CL:0000836
name: promyelocyte
def: "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, and containing a few, as yet undifferentiated, cytoplasmic granules." [GOC:add, ISBN:0721601464]
is_a: CL:0000839 ! myeloid progenitor cell
relationship: develops_from CL:0000835 ! myeloblast

[Term]
id: CL:0000837
name: hematopoietic progenitor cell
def: "A progenitor cell of any hematopoietic lineage, potentially multipotent." [GOC:add]
comment: Note that this is a class of cell types, not an identified single cell type.
synonym: "hemopoietic progenitor cell" EXACT []
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000037 ! hematopoietic stem cell

[Term]
id: CL:0000838
name: lymphoid progenitor cell
def: "A progenitor cell of any lymphoid lineage, potentially multipotent." [GOC:add]
comment: Note that this is a class of cell types, not an identified single cell type.
is_a: CL:0000837 ! hematopoietic progenitor cell

[Term]
id: CL:0000839
name: myeloid progenitor cell
def: "A progenitor cell of any myeloid lineage, potentially multipotent." [GOC:add]
comment: Note that this is a class of cell types, not an identified single cell type.
is_a: CL:0000837 ! hematopoietic progenitor cell

[Term]
id: CL:0000840
name: immature myeloid dendritic cell
def: "An immature cell of the myeloid dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues." [GOC:add, PMID:9521319]
is_a: CL:0000782 ! myeloid dendritic cell
relationship: develops_from CL:0000576 ! monocyte

[Term]
id: CL:0000841
name: mature myeloid dendritic cell
def: "A mature cell of the myeloid dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." [GOC:add, PMID:9521319]
is_a: CL:0000782 ! myeloid dendritic cell
relationship: develops_from CL:0000840 ! immature myeloid dendritic cell

[Term]
id: CL:0000842
name: mononuclear cell
def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add]
is_a: CL:0000738 ! leukocyte

[Term]
id: CL:0000843
name: follicular B cell
def: "A resting mature B cell that has the phenotype CD23-positive and CD21-positive, and found typically in the B cell follicle region of the spleen." [GOC:add, ISBN:0781735149]
is_a: CL:0000785 ! mature B cell

[Term]
id: CL:0000844
name: germinal center B cell
def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes." [GOC:add, ISBN:0781735149]
is_a: CL:0000785 ! mature B cell
relationship: develops_from CL:0000818 ! transitional stage B cell
relationship: develops_from CL:0000843 ! follicular B cell

[Term]
id: CL:0000845
name: marginal zone B cell
def: "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL." [GOC:add, ISBN:0781735149, PMID:10933592]
is_a: CL:0000785 ! mature B cell

[Term]
id: CL:0000846
name: vestibular dark cell
def: "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings." [PMID:11223304]
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0000847
name: ciliated olfactory receptor neuron
def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." [PMID:16841163]
synonym: "ciliated olfactory sensory neuron" EXACT []
synonym: "ciliated sensory neuron" EXACT []
is_a: CL:0000207 ! olfactory receptor cell

[Term]
id: CL:0000848
name: microvillous olfactory receptor neuron
def: "An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli." [PMID:16841163]
synonym: "microvillous olfactory sensory neuron" EXACT []
synonym: "microvillous sensory neuron" RELATED []
is_a: CL:0000207 ! olfactory receptor cell

[Term]
id: CL:0000849
name: crypt olfactory receptor neuron
def: "An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli." [PMID:16841163]
synonym: "crypt cell" EXACT []
synonym: "crypt olfactory sensory neuron" EXACT []
synonym: "crypt sensory neuron" EXACT []
is_a: CL:0000207 ! olfactory receptor cell

[Term]
id: CL:0000850
name: serotonergic neuron
alt_id: CL:0000403
def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl]
synonym: "5-HT neuron" EXACT []
synonym: "5-hydroxytryptamine neuron" EXACT []
synonym: "serotinergic neuron" RELATED []
xref: FBbt:00005133
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000851
name: neuromast mantle cell
def: "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." [ISBN:0125296509]
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000852
name: neuromast support cell
def: "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." [ISBN:0125296509]
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000853
name: olfactory epithelial support cell
def: "Olfactory epithelial support cell is a non ciliated columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium." [SANBI:mhl]
synonym: "olfactory sustentacular cell" EXACT []
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0000854
name: interneuromast cell
def: "Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts." [SANBI:mhl]
is_a: CL:0000133 ! neurectodermal cell
relationship: develops_from CL:0000032 ! neuroplacodal cell

[Term]
id: CL:0000855
name: hair cell
def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [SANBI:mhl]
is_a: CL:0000199 ! mechanoreceptor cell

[Term]
id: CL:0000856
name: neuromast hair cell
def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [SANBI:mhl]
is_a: CL:0000855 ! hair cell

[Term]
id: CL:0000857
name: slow muscle myoblast
def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." [SANBI:mhl]
is_a: CL:0000515 ! skeletal muscle myoblast

[Term]
id: CL:0000858
name: fast muscle myoblast
def: "A skeletal muscle myoblast that differentiates into fast muscle fibers." [SANBI:mhl]
is_a: CL:0000515 ! skeletal muscle myoblast

[Term]
id: CL:0000859
name: cementum secreting cell
def: "A secretory cell that secretes cementum, a bony substance that covers the root of a tooth." [SANBI:mhl]
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000860
name: inflammatory monocyte
def: "A type of monocyte characterised by high expression of CCR2, increased responsiveness to monocyte chemoattractant CCL2/MCP1, and increased phagocytic activity." [GO_REF:0000031, GOC:ana, PMID:16322748, PMID:18303997]
comment: Markers: CCR2+CXCCR1- (human, mouse, rat); human: CD16-, mouse: CD62L+,Ly6C+,7/4+; role or process: inflammation (inflammatory response).
is_a: CL:0000576 ! monocyte

[Term]
id: CL:0000861
name: elicited macrophage
def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response." [GO_REF:0000031, GOC:add, GOC:ana, PMID:15771589]
comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response).
is_a: CL:0000235 ! macrophage
relationship: develops_from CL:0000860 ! inflammatory monocyte

[Term]
id: CL:0000862
name: suppressor macrophage
def: "A macrophage that suppresses immune reponses." [GOC:add]
comment: Markers: May express: IL10, TGFbeta.
is_a: CL:0000861 ! elicited macrophage

[Term]
id: CL:0000863
name: inflammatory macrophage
def: "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatoy cytokines, ROS and NO, and shows potent microbicidal activity." [GO_REF:0000031, GOC:ana]
comment: Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response).
synonym: "classically activated macrophage" EXACT []
synonym: "M1 macrophage" RELATED []
is_a: CL:0000861 ! elicited macrophage

[Term]
id: CL:0000864
name: tissue-resident macrophage
def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana]
is_a: CL:0000235 ! macrophage

[Term]
id: CL:0000865
name: gastrointestinal tract (lamina propria) macrophage
def: "A gut-associated lymphoid tissue macrophage found in lamnia propria of the gut." [GO_REF:0000031, GOC:ana]
is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage

[Term]
id: CL:0000866
name: thymic macrophage
def: "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." [GO_REF:0000031, GOC:ana]
comment: Role or process: immune, clearance of apoptotic thymocytes, antigen-presentation.
is_a: CL:0000864 ! tissue-resident macrophage

[Term]
id: CL:0000867
name: secondary lymphoid organ macrophage
def: "A tissue-resident macrophage found in a secondary lymphoid organ." [GO_REF:0000031, GOC:ana]
is_a: CL:0000864 ! tissue-resident macrophage

[Term]
id: CL:0000868
name: lymph node macrophage
def: "A secondary lymophoid organ macrophage found in a lymph node." [GO_REF:0000031, GOC:ana]
is_a: CL:0000867 ! secondary lymphoid organ macrophage

[Term]
id: CL:0000869
name: tonsillar macrophage
def: "A gut-associated lymphoid tissue macrophage found in tonsils." [GO_REF:0000031, GOC:ana]
is_a: CL:0000884 ! mucosa-associated lymphoid tissue macrophage

[Term]
id: CL:0000870
name: Peyer's patch macrophage
def: "A gut-associated lymphoid tissue macrophage found in the Peyer's patches." [GO_REF:0000031, GOC:ana]
is_a: CL:0000885 ! gut-associated lymphoid tissue macrophage

[Term]
id: CL:0000871
name: splenic macrophage
def: "A secondary lymophoid organ macrophage found in the spleen." [GO_REF:0000031, GOC:ana, PMID:15771589, PMID:16322748]
comment: Role or process: immune, clearance of apoptotic and senescent cells.
is_a: CL:0000867 ! secondary lymphoid organ macrophage

[Term]
id: CL:0000872
name: splenic marginal zone macrophage
def: "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation." [GO_REF:0000031, GOC:ana]
comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+.
is_a: CL:0000871 ! splenic macrophage

[Term]
id: CL:0000873
name: splenic metallophillic macrophage
def: "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus." [GO_REF:0000031, GOC:ana]
comment: Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+.
is_a: CL:0000871 ! splenic macrophage

[Term]
id: CL:0000874
name: splenic red pulp macrophage
def: "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes." [GO_REF:0000031, GOC:ana]
comment: Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes.
is_a: CL:0000871 ! splenic macrophage

[Term]
id: CL:0000875
name: resident monocyte
def: "Subset of monocytes characterised by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, but increased co-stimulatory activity." [GO_REF:0000031, GOC:ana, PMID:16322748, PMID:18303997]
comment: Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-.
is_a: CL:0000576 ! monocyte

[Term]
id: CL:0000876
name: splenic white pulp macrophage
def: "A splenic macrophage found in the white pulp of the spleen." [GO_REF:0000031, GOC:ana]
comment: Markers: Mouse: F4/80-, CD68+, macrosialin+.
is_a: CL:0000871 ! splenic macrophage

[Term]
id: CL:0000877
name: splenic tingible body macrophage
def: "A splenic white pulp macrophage found in and around the germinal centres of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centres." [GO_REF:0000031, GOC:ana]
is_a: CL:0000876 ! splenic white pulp macrophage

[Term]
id: CL:0000878
name: central nervous system macrophage
def: "A tissue-resident macrophage found in the central nervous system." [GO_REF:0000031, GOC:ana, PMID:16322748]
synonym: "CNS macrophage" EXACT []
is_a: CL:0000864 ! tissue-resident macrophage

[Term]
id: CL:0000879
name: meningeal macrophage
def: "A central nervous system macrophage found in the meninges (the three membranes that surround the brain)." [GO_REF:0000031, GOC:ana]
is_a: CL:0000878 ! central nervous system macrophage

[Term]
id: CL:0000880
name: choroid-plexus macrophage
def: "A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain." [GO_REF:0000031, GOC:ana]
is_a: CL:0000878 ! central nervous system macrophage

[Term]
id: CL:0000881
name: perivascular macrophage
def: "A central nervous system macrophage found in small blood vessels in the brain." [GO_REF:0000031, GOC:ana, PMID:16507898]
comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+.
is_a: CL:0000878 ! central nervous system macrophage

[Term]
id: CL:0000882
name: thymic medullary macrophage
def: "A thymic macrophage found in the thymic medulla." [GO_REF:0000031, GOC:ana]
is_a: CL:0000866 ! thymic macrophage

[Term]
id: CL:0000883
name: thymic cortical macrophage
def: "A thymic macrophage found in the thymic cortex." [GO_REF:0000031, GOC:ana]
is_a: CL:0000866 ! thymic macrophage

[Term]
id: CL:0000884
name: mucosa-associated lymphoid tissue macrophage
def: "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." [GO_REF:0000031, GOC:ana]
is_a: CL:0000867 ! secondary lymphoid organ macrophage

[Term]
id: CL:0000885
name: gut-associated lymphoid tissue macrophage
def: "A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut." [GO_REF:0000031, GOC:ana]
is_a: CL:0000884 ! mucosa-associated lymphoid tissue macrophage

[Term]
id: CL:0000886
name: nasal and broncial associated lymphoid tissue macrophage
def: "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." [GO_REF:0000031, GOC:ana]
is_a: CL:0000884 ! mucosa-associated lymphoid tissue macrophage

[Term]
id: CL:0000887
name: lymph node subcapsular sinus macrophage
def: "A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens." [GO_REF:0000031, GOC:ana PMID\:14668803, PMID:17934446]
is_a: CL:0000868 ! lymph node macrophage

[Term]
id: CL:0000888
name: lymph node tingible body macrophage
def: "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centres, and that participates in phagocytosis of apoptotic B cells from the germinal centres." [GO_REF:0000031, GOC:ana]
is_a: CL:0000868 ! lymph node macrophage

[Term]
id: CL:0000889
name: myeloid suppressor cell
def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays." [GO_REF:0000031, GOC:add, GOC:ana, PMID:16168663, PMID:17016554, PMID:17016559]
comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis.
is_a: CL:0000766 ! myeloid leukocyte

[Term]
id: CL:0000890
name: alternatively activated macrophage
def: "An elicited macrophage characterized by low production of pro-inflamatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling." [GO_REF:0000031, GOC:ana]
comment: Role or process: tissue remodeling.
synonym: "M2 macrophage" RELATED []
is_a: CL:0000861 ! elicited macrophage

[Term]
id: CL:0000891
name: foam cell
def: "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add]
is_a: CL:0000548 ! animal cell

[Term]
id: CL:0000892
name: smooth muscle cell derived foam cell
def: "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add]
is_a: CL:0000891 ! foam cell
relationship: develops_from CL:0000192 ! smooth muscle cell

[Term]
id: CL:0000893
name: thymocyte
def: "An immature T cell located in the thymus." [GO_REF:0000031, GOC:add]
synonym: "immature T cell" BROAD []
synonym: "immature T lymphocyte" BROAD []
synonym: "immature T-cell" BROAD []
synonym: "immature T-lymphocyte" BROAD []
is_a: CL:0000084 ! T cell

[Term]
id: CL:0000894
name: DN1 thymic pro-T cell
def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "DN1 thymic pro-T lymphocyte" EXACT []
synonym: "DN1 thymic pro-T-cell" EXACT []
synonym: "DN1 thymic pro-T-lymphocyte" EXACT []
synonym: "DN1 thymic progenitor T cell" EXACT []
synonym: "DN1 thymocyte" EXACT []
is_a: CL:0000827 ! pro-T cell

[Term]
id: CL:0000895
name: naive thymus-derived CD4-positive, alpha-beta T cell
def: "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive and CD62L-positive. This cell type develops in the thymus." [GO_REF:0000031, GOC:add, GOC:pam]
comment: These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs.
synonym: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT []
synonym: "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000898 ! naive T cell
relationship: develops_from CL:0000810 ! CD4-positive, alpha-beta thymocyte

[Term]
id: CL:0000896
name: activated CD4-positive, alpha-beta T cell
def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "activated CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "activated CD4-positive, alpha-beta T-cell" EXACT []
synonym: "activated CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
relationship: develops_from CL:0000895 ! naive thymus-derived CD4-positive, alpha-beta T cell

[Term]
id: CL:0000897
name: CD4-positive, alpha-beta memory T cell
def: "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive." [GO_REF:0000031, GOC:add, GOC:pam, ISBN:0781735149]
synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta memory T-cell" EXACT []
synonym: "CD4-positive, alpha-beta memory T-lymphocyte" EXACT []
is_a: CL:0000624 ! CD4-positive, alpha-beta T cell
is_a: CL:0000813 ! memory T cell
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell

[Term]
id: CL:0000898
name: naive T cell
def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "naive T lymphocyte" EXACT []
synonym: "naive T-cell" EXACT []
synonym: "naive T-lymphocyte" EXACT []
is_a: CL:0000084 ! T cell

[Term]
id: CL:0000899
name: T-helper 17 cell
def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "helper T cell type 17" EXACT []
synonym: "Th17 cell" EXACT []
synonym: "Th17 T cell" EXACT []
synonym: "Th17 T lymphocyte" EXACT []
synonym: "Th17 T-cell" EXACT []
synonym: "Th17 T-lymphocyte" EXACT []
is_a: CL:0000492 ! CD4-positive helper T cell
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell

[Term]
id: CL:0000900
name: naive thymus-derived CD8-positive, alpha-beta T cell
def: "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CCR7 positive and CD127 positive." [GO_REF:0000031, GOC:add, GOC:pam, ISBN:0781735149]
comment: Additional markers in human are CD45RA. This cell traffics in secondary lymphoid organs and blood.
synonym: "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "naive thymus-dervied CD8-positive, alpha-beta T-cell" EXACT []
synonym: "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000898 ! naive T cell
relationship: develops_from CL:0000811 ! CD8-positive, alpha-beta thymocyte

[Term]
id: CL:0000901
name: Tr1 cell
def: "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "T-regulatory T cell type 1" EXACT []
synonym: "Tr1 T cell" EXACT []
synonym: "Tr1 T lymphocyte" EXACT []
synonym: "Tr1 T-cell" EXACT []
synonym: "Tr1 T-lymphocyte" EXACT []
is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell

[Term]
id: CL:0000902
name: induced T-regulatory cell
def: "CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "adaptive Treg" RELATED []
synonym: "aTreg" RELATED []
synonym: "induced regulatory T cell" EXACT []
synonym: "induced regulatory T lymphocyte" EXACT []
synonym: "induced regulatory T-cell" EXACT []
synonym: "induced regulatory T-lymphocyte" EXACT []
synonym: "induced Treg" EXACT []
synonym: "iTreg" EXACT []
is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell

[Term]
id: CL:0000903
name: natural T-regulatory cell
def: "CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "natural regulatory T cell" EXACT []
synonym: "natural regulatory T lymphocyte" EXACT []
synonym: "natural regulatory T-cell" EXACT []
synonym: "natural regulatory T-lymphocyte" EXACT []
synonym: "natural Treg" EXACT []
synonym: "nTreg" EXACT []
is_a: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte

[Term]
id: CL:0000904
name: central memory CD4-positive, alpha-beta T cell
def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "central CD4-positive, alpha-beta memory T cell" EXACT []
synonym: "central CD4-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "central CD4-positive, alpha-beta memory T-cell" EXACT []
synonym: "central CD4-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "central memory CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "central memory CD4-positive, alpha-beta T-cell" EXACT []
synonym: "central memory CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell

[Term]
id: CL:0000905
name: effector memory CD4-positive, alpha-beta T cell
def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "effector CD4-positive, alpha-beta memory T cell" EXACT []
synonym: "effector CD4-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "effector CD4-positive, alpha-beta memory T-cell" EXACT []
synonym: "effector CD4-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "effector memory CD4-positive, alpha-beta T lymphocyte" EXACT []
synonym: "effector memory CD4-positive, alpha-beta T-cell" EXACT []
synonym: "effector memory CD4-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell

[Term]
id: CL:0000906
name: activated CD8-positive, alpha-beta T cell
def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "activated CD8-positive, alpha-beta T-cell" EXACT []
synonym: "activated CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
relationship: develops_from CL:0000900 ! naive thymus-derived CD8-positive, alpha-beta T cell

[Term]
id: CL:0000907
name: central memory CD8 positive, alpha-beta T cell
def: "A CD8-positive, alpha beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "central CD8-positive, alpha-beta memory T cell" EXACT []
synonym: "central CD8-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "central CD8-positive, alpha-beta memory T-cell" EXACT []
synonym: "central CD8-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "central memory CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "central memory CD8-positive, alpha-beta T-cell" EXACT []
synonym: "central memory CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell

[Term]
id: CL:0000908
name: CD8-positive, alpha-beta cytokine secreting effector T cell
def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT []
synonym: "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000912 ! helper T cell
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell

[Term]
id: CL:0000909
name: CD8-positive, alpha-beta memory T cell
def: "A CD8-positive, alpha-beta T cell with memory phenotype." [GO_REF:0000031, GOC:add]
synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "CD8-positive, alpha-beta memory T-cell" EXACT []
synonym: "CD8-positive, alpha-beta memory T-lymphocyte" EXACT []
is_a: CL:0000625 ! CD8-positive, alpha-beta T cell
is_a: CL:0000813 ! memory T cell
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell

[Term]
id: CL:0000910
name: cytotoxic T cell
def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "cytotoxic T lymphocyte" EXACT []
synonym: "cytotoxic T-cell" EXACT []
synonym: "cytotoxic T-lymphocyte" EXACT []
is_a: CL:0000911 ! effector T cell

[Term]
id: CL:0000911
name: effector T cell
def: "A differentiated T cell with ability to traffic to peripheral tissues that has acquired helper or cytotoxic functions." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "effector T lymphocyte" EXACT []
synonym: "effector T-cell" EXACT []
synonym: "effector T-lymphocyte" EXACT []
is_a: CL:0000084 ! T cell

[Term]
id: CL:0000912
name: helper T cell
def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "helper T lymphocyte" EXACT []
synonym: "helper T-cell" EXACT []
synonym: "helper T-lymphocyte" EXACT []
synonym: "T-helper cell" EXACT []
is_a: CL:0000911 ! effector T cell

[Term]
id: CL:0000913
name: effector memory CD8-positive, alpha-beta T cell
def: "A CD8-positive, alpha beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "effector CD8-positive, alpha-beta memory T cell" EXACT []
synonym: "effector CD8-positive, alpha-beta memory T lymphocyte" EXACT []
synonym: "effector CD8-positive, alpha-beta memory T-cell" EXACT []
synonym: "effector CD8-positive, alpha-beta memory T-lymphocyte" EXACT []
synonym: "effector memory CD8-positive, alpha-beta T lymphocyte" EXACT []
synonym: "effector memory CD8-positive, alpha-beta T-cell" EXACT []
synonym: "effector memory CD8-positive, alpha-beta T-lymphocyte" EXACT []
is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell

[Term]
id: CL:0000914
name: immature NK T cell
def: "A CD4-positive alpha-beta T cell expressing NK cell markers and a CD1d-restricted T cell receptor and found in the thymus." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "immature NK T lymphocyte" EXACT []
synonym: "immature NK T-cell" EXACT []
synonym: "immature NK T-lymphocyte" EXACT []
synonym: "immature NKT cell" EXACT []
is_a: CL:0000790 ! immature alpha-beta T cell
relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte

[Term]
id: CL:0000915
name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell
def: "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" EXACT []
is_a: CL:0000797 ! alpha-beta intraepithelial T cell
relationship: develops_from CL:0000811 ! CD8-positive, alpha-beta thymocyte

[Term]
id: CL:0000916
name: dendritic epidermal T cell
def: "A mature gamma-delta T cell located in the skin." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "dendritic epidermal T lymphocyte" EXACT []
synonym: "dendritic epidermal T-cell" EXACT []
synonym: "dendritic epidermal T-lymphocyte" EXACT []
is_a: CL:0000800 ! mature gamma-delta T cell

[Term]
id: CL:0000917
name: Tc1 cell
def: "A CD8-positive, alpha-beta positive T cell expressing T-bet and eomesodermin and secreting interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "T-cytotoxic T cell type 1" EXACT []
synonym: "Tc1 T cell" EXACT []
synonym: "Tc1 T lymphocyte" EXACT []
synonym: "Tc1 T-cell" EXACT []
synonym: "Tc1 T-lymphocyte" EXACT []
is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell

[Term]
id: CL:0000918
name: Tc2 cell
def: "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "T-cytotoxic T cell type 2" EXACT []
synonym: "Tc2 T cell" EXACT []
synonym: "Tc2 T lymphocyte" EXACT []
synonym: "Tc2 T-cell" EXACT []
synonym: "Tc2 T-lymphocyte" EXACT []
is_a: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell

[Term]
id: CL:0000919
name: CD8-positive, CD25-positive, alpha-beta regulatory T cell
def: "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T cell" EXACT []
synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT []
is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell

[Term]
id: CL:0000920
name: CD8-positive, CD28-negative, alpha-beta regulatory T cell
def: "CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T cell" EXACT []
synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T lymphocyte" EXACT []
synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-cell" EXACT []
synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-lymphocyte" EXACT []
is_a: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell
relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell

[Term]
id: CL:0000921
name: type I NK T cell
def: "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains." [GO_REF:0000031, GOC:add, GOC:pam]
comment: In mouse the canonical TCR is V-alpha-14, and in humans it is V-alpha 24.
synonym: "classical NK T cell" EXACT []
synonym: "invariant NK T cell" RELATED []
synonym: "type I NK T lymphocyte" EXACT []
synonym: "type I NK T-cell" EXACT []
synonym: "type I NK T-lymphocyte" EXACT []
synonym: "type I NKT cell" EXACT []
is_a: CL:0000814 ! mature NK T cell

[Term]
id: CL:0000922
name: type II NK T cell
def: "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "type II NK T lymphocyte" EXACT []
synonym: "type II NK T-cell" EXACT []
synonym: "type II NK T-lymphocyte" EXACT []
synonym: "type II NKT cell" EXACT []
is_a: CL:0000814 ! mature NK T cell

[Term]
id: CL:0000923
name: CD4-positive type I NK T cell
def: "A type I NK T cell that has the phenotype CD4-positive." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD4-positive type I NK T lymphocyte" EXACT []
synonym: "CD4-positive type I NK T-cell" EXACT []
synonym: "CD4-positive type I NK T-lymphocyte" EXACT []
synonym: "CD4-positive type I NKT cell" EXACT []
is_a: CL:0000921 ! type I NK T cell

[Term]
id: CL:0000924
name: CD4-negative, CD8-negative type I NK T cell
def: "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD4-negative, CD8-negative type I NK T lymphocyte" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-cell" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT []
synonym: "CD4-negative, CD8-negative type I NKT cell" EXACT []
is_a: CL:0000921 ! type I NK T cell

[Term]
id: CL:0000925
name: activated CD4-positive type I NK T cell
def: "A type I NK T cell that has been recently activated, secrets interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "activated CD4-positive type I NK T lymphocyte" EXACT []
synonym: "activated CD4-positive type I NK T-cell" EXACT []
synonym: "activated CD4-positive type I NK T-lymphocyte" EXACT []
synonym: "activated CD4-positive type I NKT cell" EXACT []
is_a: CL:0000814 ! mature NK T cell
is_a: CL:0000921 ! type I NK T cell
relationship: develops_from CL:0000923 ! CD4-positive type I NK T cell

[Term]
id: CL:0000926
name: CD4-positive type I NK T cell secreting interferon-gamma
def: "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD4-positive type I NK T cell secreting IFN-gamma" EXACT []
synonym: "CD4-positive type I NK T lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-positive type I NK T-cell secreting interferon-gamma" EXACT []
synonym: "CD4-positive type I NK T-lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-positive type I NKT cell secreting interferon-gamma" EXACT []
is_a: CL:0000814 ! mature NK T cell
relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell

[Term]
id: CL:0000927
name: CD4-positive type I NK T cell secreting interleukin-4
def: "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD4-positive type I NK T cell secreting IL-4" EXACT []
synonym: "CD4-positive type I NK T lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-positive type I NK T-cell secreting interleukin-4" EXACT []
synonym: "CD4-positive type I NK T-lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-positive type I NKT cell secreting interleukin-4" EXACT []
is_a: CL:0000814 ! mature NK T cell
relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell

[Term]
id: CL:0000928
name: activated CD4-negative, CD8-negative type I NK T cell
def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "activated CD4-negative, CD8-negative type I NK T lymphocyte" EXACT []
synonym: "activated CD4-negative, CD8-negative type I NK T-cell" EXACT []
synonym: "activated CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT []
synonym: "activated CD4-negative, CD8-negative type I NKT cell" EXACT []
is_a: CL:0000921 ! type I NK T cell
relationship: develops_from CL:0000924 ! CD4-negative, CD8-negative type I NK T cell

[Term]
id: CL:0000929
name: CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma
def: "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma" EXACT []
synonym: "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" EXACT []
is_a: CL:0000814 ! mature NK T cell
relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell

[Term]
id: CL:0000930
name: CD4-negative, CD8-negative type I NK T cell secreting interleukin-4
def: "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD4-negative, CD8-negative type I NK T cell secreting IL-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4" EXACT []
synonym: "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" EXACT []
is_a: CL:0000814 ! mature NK T cell
relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell

[Term]
id: CL:0000931
name: activated type II NK T cell
def: "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "activated type II NK T lymphocyte" EXACT []
synonym: "activated type II NK T-cell" EXACT []
synonym: "activated type II NK T-lymphocyte" EXACT []
synonym: "activated type II NKT cell" EXACT []
is_a: CL:0000922 ! type II NK T cell

[Term]
id: CL:0000932
name: type II NK T cell secreting interferon-gamma
def: "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "type II NK T cell secreting IFN-gamma" EXACT []
synonym: "type II NK T lymphocyte secreting interferon-gamma" EXACT []
synonym: "type II NK T-cell secreting interferon-gamma" EXACT []
synonym: "type II NK T-lymphocyte secreting interferon-gamma" EXACT []
synonym: "type II NKT cell secreting interferon-gamma" EXACT []
is_a: CL:0000814 ! mature NK T cell
relationship: develops_from CL:0000931 ! activated type II NK T cell

[Term]
id: CL:0000933
name: type II NK T cell secreting interleukin-4
def: "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "type II NK T cell secreting IL-4" EXACT []
synonym: "type II NK T lymphocyte secreting interleukin-4" EXACT []
synonym: "type II NK T-cell secreting interleukin-4" EXACT []
synonym: "type II NK T-lymphocyte secreting interleukin-4" EXACT []
synonym: "type II NKT cell secreting interleukin-4" EXACT []
is_a: CL:0000814 ! mature NK T cell
relationship: develops_from CL:0000931 ! activated type II NK T cell

[Term]
id: CL:0000934
name: CD4-positive, alpha-beta cytotoxic T cell
def: "A CD4-positive, alpha-beta T cell that has cytotoxic function." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD4-positive, alpha-beta cytotoxic T lymphocyte" EXACT []
synonym: "CD4-positive, alpha-beta cytotoxic T-cell" EXACT []
synonym: "CD4-positive, alpha-beta cytotoxic T-lymphocyte" EXACT []
is_a: CL:0000910 ! cytotoxic T cell
relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell

[Term]
id: CL:0000935
name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell
def: "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte" EXACT []
synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell" EXACT []
synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte" EXACT []
is_a: CL:0000797 ! alpha-beta intraepithelial T cell

[Term]
id: CL:0000936
name: early lymphoid progenitor
def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, CD117-positive, Sca-1-positive, FLT3-positive, and CD34 positive." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "ELP" EXACT []
is_a: CL:0000838 ! lymphoid progenitor cell

[Term]
id: CL:0000937
name: pre-natural killer cell
def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, CD117-positive, and CD161-positive." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "pre-NK cell" EXACT []
is_a: CL:0000623 ! natural killer cell

[Term]
id: CL:0000938
name: CD56-bright cytokine secreting natural killer cell
def: "NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "CD56-bright cytokine secreting NK cell" EXACT []
is_a: CL:0000824 ! mature natural killer cell

[Term]
id: CL:0000939
name: cytotoxic CD56-dim natural killer cell
def: "A mature natural killer cell that has the phenotype CD56-dim abd CD16-positive and is capable of cytotoxic function and cytokine production." [GO_REF:0000031, GOC:add, GOC:pam]
comment: This population is mainly found in human.
synonym: "cytotoxic CD56-dim NK cell" EXACT []
is_a: CL:0000824 ! mature natural killer cell

[Term]
id: CL:0000940
name: mucosal invariant T cell
def: "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." [GO_REF:0000031, GOC:add, GOC:pam]
synonym: "mucosal invariant T lymphocyte" EXACT []
synonym: "mucosal invariant T-cell" EXACT []
synonym: "mucosal invariant T-lymphocyte" EXACT []
is_a: CL:0000789 ! alpha-beta T cell

[Term]
id: CL:0000941
name: thymic conventional dendritic cell
def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." [GO_REF:0000031, GOC:add, GOC:pam]
comment: In the mouse this cell expresses CD8-alpha-alpha.
is_a: CL:0000990 ! conventional dendritic cell
relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell

[Term]
id: CL:0000942
name: thymic plasmacytoid dendritic cell
def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." [GO_REF:0000031, GOC:add, GOC:pam]
is_a: CL:0000784 ! plasmacytoid dendritic cell
relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell

[Term]
id: CL:0000943
name: Be1 Cell
def: "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." [GO_REF:0000031, GOC:msz, PMID:11101868]
synonym: "B effector cell type 1" RELATED []
is_a: CL:0000968 ! Be cell

[Term]
id: CL:0000944
name: Be2 cell
def: "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." [GO_REF:0000031, GOC:msz, PMID:11101868]
synonym: "B effector cell type 2" RELATED []
is_a: CL:0000968 ! Be cell

[Term]
id: CL:0000945
name: lymphocyte of B lineage
def: "A lymphocyte of B lineage is a lymphocyte that expresses CD19 (P15391/CD19_HUMAN; PIRSF016630) on the cell surface. An additional defining characteristic is the commitment to express an immunoglobulin complex." [GO_REF:0000031, GOC:add, GOC:rhs, ISBN:0781735149]
comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plamsablasts and plasma cells).
is_a: CL:0000542 ! lymphocyte
relationship: develops_from CL:0000826 ! pro-B cell

[Term]
id: CL:0000946
name: antibody secreting cell
def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, ISBN:0721601464, ISBN:0781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003. 781735149"]
is_a: CL:0000945 ! lymphocyte of B lineage

[Term]
id: CL:0000947
name: IgE plasma cell
def: "A long lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz]
is_a: CL:0000974 ! long lived plasma cell

[Term]
id: CL:0000948
name: IgE memory B cell
def: "A class switched memory B cell that expresses IgE on the cell surface." [GO_REF:0000031, GOC:rhs]
is_a: CL:0000972 ! class switched memory B cell

[Term]
id: CL:0000949
name: IgD plasmablast
def: "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." [GO_REF:0000031, GOC:msz]
is_a: CL:0000980 ! plasmablast

[Term]
id: CL:0000950
name: IgE plasmablast
def: "A plasmablast that secretes IgE." [GO_REF:0000031, GOC:msz]
is_a: CL:0000980 ! plasmablast

[Term]
id: CL:0000951
name: IgE short-lived plasma cell
def: "A short lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."]
is_a: CL:0000975 ! short lived plasma cell

[Term]
id: CL:0000952
name: preBCR-positive large pre-B-II cell
def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that expresses the pre-B cell receptor, composed of surrogate light chain protein (SL), which is composed of VpreB (P12018/VPREB_HUMAN; PIRSF001974), Lambda 5/14.1 (P15814/IGLL1_HUMAN; PIRSF001989), in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." [GO_REF:0000031, GOC:rhs, PMID:9785673]
is_a: CL:0000957 ! large pre-B-II cell

[Term]
id: CL:0000953
name: preBCR-negative large pre-B-II cell
def: "An preBRC-negative large pre-B-II cell is a large pre-B-II cell that lacks expression of the pre-B cell receptor, composed of surrogate light chain protein (SL), which is composed of VpreB (P12018/VPREB_HUMAN; PIRSF001974) and Lambda 5/14.1 (P15814/IGLL1_HUMAN; PIRSF001989), in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." [GO_REF:0000031, GOC:rhs, PMID:9785673]
is_a: CL:0000957 ! large pre-B-II cell

[Term]
id: CL:0000954
name: small pre-B-II cell
def: "A small pre-B-II cell is a pre-B-II cell that expresses Rag1 (P15918/RAG1_HUMAN), Rag2 (P55895/RAG2_HUMAN; PIRSF015717), lack expression of preBCR and BCR, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." [GO_REF:0000031, GOC:rhs, PMID:9785673]
is_a: CL:0000817 ! precursor B cell

[Term]
id: CL:0000955
name: pre-B-II cell
def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34 (P28906/CD34_HUMAN; PIRSF028749), TdT (P04053/TDT_HUMAN; PIRSF000817), immunoglobulin kappa light chain and immunoglobulin lambda light chain." [GO_REF:0000031, GOC:rhs, PMID:9785673]
synonym: "Large pre-B-II" RELATED [ISBN:781735149]
synonym: "pre-B-lymphocyte" EXACT []
is_a: CL:0000817 ! precursor B cell
relationship: develops_from CL:0000826 ! pro-B cell

[Term]
id: CL:0000956
name: pre-B-I cell
def: "A pre-B-I cell is a precursor B cell that expresses CD34 (P28906/CD34_HUMAN; PIRSF028749) and surrogate immunoglobulin light chain on the cell surface, VpreB (P12018/VPREB_HUMAN; PIRSF001974), Lambda 5/14.1 (P15814/IGLL1_HUMAN; PIRSF001989), TdT (P04053/TDT_HUMAN; PIRSF000817), Rag1 (P15918/RAG1_HUMAN), Rag2 (P55895/RAG2_HUMAN; PIRSF015717) intracellularly, carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." [GO_REF:0000031, GOC:rhs, PMID:9785673]
is_a: CL:0000817 ! precursor B cell

[Term]
id: CL:0000957
name: large pre-B-II cell
def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and lacks expression of Rag1 (P15918/RAG1_HUMAN) and Rag2 (P55895/RAG2_HUMAN; PIRSF015717)." [GO_REF:0000031, GOC:rhs, PMID:9785673]
is_a: CL:0000817 ! precursor B cell

[Term]
id: CL:0000958
name: T1 B cell
def: "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative." [GO_REF:0000031, GOC:rhs, PMID:12810111]
is_a: CL:0000818 ! transitional stage B cell

[Term]
id: CL:0000959
name: T2 B cell
def: "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles." [GO_REF:0000031, GOC:msz, PMID:12810111]
is_a: CL:0000818 ! transitional stage B cell
relationship: develops_from CL:0000958 ! T1 B cell

[Term]
id: CL:0000960
name: T3 B cell
def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive." [GO_REF:0000031, GOC:msz, PMID:12810111, PMID:17174121]
synonym: "An1 B cell" EXACT [PMID:17174121]
is_a: CL:0000818 ! transitional stage B cell
relationship: develops_from CL:0000959 ! T2 B cell

[Term]
id: CL:0000961
name: Bm1 B cell
def: "A follicular B cell that expresses IgD, but not CD23 or CD38. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." [GO_REF:0000031, GOC:msz, PMID:17992590, PMID:8006591]
is_a: CL:0000843 ! follicular B cell
relationship: develops_from CL:0000818 ! transitional stage B cell

[Term]
id: CL:0000962
name: Bm2 B cell
def: "A follicular B cell that expresses IgD and CD23 and CD38. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." [GO_REF:0000031, GOC:msz, PMID:17992590, PMID:8006591]
is_a: CL:0000843 ! follicular B cell
relationship: develops_from CL:0000961 ! Bm1 B cell

[Term]
id: CL:0000963
name: Bm3-delta B cell
def: "A germinal center B cell that develops from a Bm3 B cell." [GO_REF:0000031, GOC:add, GOC:msz]
is_a: CL:0000844 ! germinal center B cell
relationship: develops_from CL:0000965 ! Bm3 B cell

[Term]
id: CL:0000964
name: Bm2' B cell
def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positivie, and CD23-negative." [GO_REF:0000031, GOC:msz, PMID:17992590, PMID:8006591]
synonym: "Bm2-prime B cell" EXACT []
synonym: "germinal center founder cell" RELATED []
is_a: CL:0000844 ! germinal center B cell
relationship: develops_from CL:0000962 ! Bm2 B cell

[Term]
id: CL:0000965
name: Bm3 B cell
def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." [GO_REF:0000031, GOC:msz, PMID:8006591]
synonym: "centroblast" RELATED [PMID:8006591]
is_a: CL:0000844 ! germinal center B cell
relationship: develops_from CL:0000964 ! Bm2' B cell

[Term]
id: CL:0000966
name: Bm4 B cell
def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." [GO_REF:0000031, GOC:msz, PMID:8006591]
synonym: "centrocyte" RELATED [PMID:17992590]
is_a: CL:0000844 ! germinal center B cell
relationship: develops_from CL:0000963 ! Bm3-delta B cell

[Term]
id: CL:0000967
name: Bm5 B cell
def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." [GO_REF:0000031, GOC:msz, PMID:8006591]
is_a: CL:0000787 ! memory B cell
relationship: develops_from CL:0000966 ! Bm4 B cell

[Term]
id: CL:0000968
name: Be cell
def: "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." [GO_REF:0000031, GOC:msz, PMID:11101868]
synonym: "B effector cell" RELATED []
is_a: CL:0000785 ! mature B cell

[Term]
id: CL:0000969
name: regulatory B cell
def: "A mature B cell that has the phenotype CD1b-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses." [GO_REF:0000031, GOC:msz, PMID:11869683]
is_a: CL:0000785 ! mature B cell

[Term]
id: CL:0000970
name: unswitched memory B cell
def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive and/or IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." [GO_REF:0000031, GOC:rhs, ISBN:0781765196 "Fundamental Immunology (ed. W.E. Paul)"]
is_a: CL:0000787 ! memory B cell
relationship: develops_from CL:0000980 ! plasmablast

[Term]
id: CL:0000971
name: IgM memory B cell
def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." [GO_REF:0000031, GOC:rhs]
is_a: CL:0000970 ! unswitched memory B cell

[Term]
id: CL:0000972
name: class switched memory B cell
def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore does not express IgM or IgD on the cell surface. These cells usually express CD27 and either IgG, IgE, or IgA on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196]
is_a: CL:0000787 ! memory B cell
relationship: develops_from CL:0000970 ! unswitched memory B cell

[Term]
id: CL:0000973
name: IgA memory B cell
def: "A class switched memory B cell that expresses IgA." [GO_REF:0000031, GOC:msz]
is_a: CL:0000972 ! class switched memory B cell

[Term]
id: CL:0000974
name: long lived plasma cell
def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." [GO_REF:0000031, GOC:msz, ISBN:9780781765190 "Fundamental Immunology, 6ed (Paul,ed), 2003"]
is_a: CL:0000786 ! plasma cell
relationship: develops_from CL:0000975 ! short lived plasma cell

[Term]
id: CL:0000975
name: short lived plasma cell
def: "A fully differentiated plasma cell that lives for months." [GO_REF:0000031, GOC:msz]
is_a: CL:0000786 ! plasma cell
relationship: develops_from CL:0000980 ! plasmablast

[Term]
id: CL:0000976
name: IgA short lived plasma cell
def: "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." [GO_REF:0000031, GOC:msz, ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003. 781735149"]
is_a: CL:0000975 ! short lived plasma cell

[Term]
id: CL:0000977
name: IgG short-lived plasma cell
def: "A short lived plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, IBSN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."]
is_a: CL:0000975 ! short lived plasma cell

[Term]
id: CL:0000978
name: IgM short lived plasma cell
def: "A short lived plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, IBSN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."]
is_a: CL:0000975 ! short lived plasma cell

[Term]
id: CL:0000979
name: IgG memory B cell
def: "An IgG memory B cell is a class switched memory B cell that has class switched and expresses IgG on the cell surface." [GO_REF:0000031, GOC:rhs]
is_a: CL:0000972 ! class switched memory B cell

[Term]
id: CL:0000980
name: plasmablast
def: "An activated mature (naive or memory) B cell that is secreting Immunoglobulin, typified by expression of CD27 and CD38 but not CD138." [GO_REF:0000031, GOC:msz]
is_a: CL:0000946 ! antibody secreting cell
relationship: develops_from CL:0000788 ! naive B cell
relationship: develops_from CL:0000967 ! Bm5 B cell

[Term]
id: CL:0000981
name: double negative memory B cell
def: "A memory B cell with the phenotype IgD-negative and CD27-negative." [GO_REF:0000031, GOC:msz]
is_a: CL:0000787 ! memory B cell

[Term]
id: CL:0000982
name: IgG plasmablast
def: "A plasmablast that secretes IgG." [GO_REF:0000031, GOC:msz]
is_a: CL:0000980 ! plasmablast

[Term]
id: CL:0000983
name: IgM plasmablast
def: "A plasmablast that secretes IgM." [GO_REF:0000031, GOC:msz]
is_a: CL:0000980 ! plasmablast

[Term]
id: CL:0000984
name: IgA plasmablast
def: "A plasmablast that secretes IgA." [GO_REF:0000031, GOC:msz]
is_a: CL:0000980 ! plasmablast

[Term]
id: CL:0000985
name: IgG plasma cell
def: "A fully differentiated plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."]
is_a: CL:0000974 ! long lived plasma cell

[Term]
id: CL:0000986
name: IgM plasma cell
def: "A fully differentiated plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."]
is_a: CL:0000974 ! long lived plasma cell

[Term]
id: CL:0000987
name: IgA plasma cell
def: "A fully differentiated plasma cell that secretes IgA." [GO_REF:0000031, GOC:msz, ISBN:781735149 "Fundamental Immunology, 6th ed. (WE Paul, ed) Wolters Kluwer (Philadelphia), 2003."]
is_a: CL:0000974 ! long lived plasma cell

[Term]
id: CL:0000988
name: hematopoietic cell
def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add]
synonym: "haematopoietic cell" EXACT []
synonym: "haemopoietic cell" EXACT []
synonym: "hemopoietic cell" EXACT []
is_a: CL:0000000 ! cell

[Term]
id: CL:0000989
name: CD11c-low plasmacytoid dendritic cell
def: "CD11c-low plasmacytoid dendritic cell is a leukocyte that has a low plasma membrane amount of CD11c, has plasma membrane part CD45R and GR1 and lacks plasma membrane part CD11b, CD3, CD34, CD56, and CD19." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486]
xref: DC_CL:0000001
is_a: CL:0000784 ! plasmacytoid dendritic cell

[Term]
id: CL:0000990
name: conventional dendritic cell
def: "Conventional dendritic cell is a leukocyte that has a high plasma membrane amount of CD11c and lacks plasma membrane part CD19, CD3, CD34, and CD56." [GO_REF:0000031, GOC:amm, PMID:17850486]
xref: DC_CL:0000003
is_a: CL:0000451 ! dendritic cell

[Term]
id: CL:0000991
name: CD11c-negative plasmacytoid dendritic cell
def: "CD11c-negative plasmacytoid dendritic cell is a leukocyte that lacks plasma membrane part CD11c, CD19, CD3, CD34, and CD56 and has plasma membrane part CD123, CD303, CD45RA, and ILT7." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486]
xref: DC_CL:0000004
is_a: CL:0000784 ! plasmacytoid dendritic cell

[Term]
id: CL:0000992
name: immature CD11c-low plasmacytoid dendritic cell
def: "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that has a low plasma membrane amount of CD80 and CD86." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486]
xref: DC_CL:0000006
is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell
relationship: develops_from CL:0001029 ! common dendritic progenitor

[Term]
id: CL:0000993
name: mature CD11c-low plasmacytoid dendritic cell
def: "A mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that has plasma membrane part CD83 and has a high plasma membrane amount of CD80, CD86, and MHCII." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486]
xref: DC_CL:0000007
is_a: CL:0000989 ! CD11c-low plasmacytoid dendritic cell

[Term]
id: CL:0000994
name: immature CD11c-negative plasmacytoid dendritic cell
def: "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell that lacks plasma membrane part CD80 and has a low plasma membrane amount of CD86 and MHCII." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486]
xref: DC_CL:0000008
is_a: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell
relationship: develops_from CL:0000995 ! CD71-positive common myeloid progenitor OR CD7-negative lymphoid progenitor OR CD7-positive lymphoid progenitor

[Term]
id: CL:0000995
name: CD71-positive common myeloid progenitor OR CD7-negative lymphoid progenitor OR CD7-positive lymphoid progenitor
xref: DC_CL:1100000
is_a: CL:0000837 ! hematopoietic progenitor cell
union_of: CL:0001026 ! CD71-positive common myeloid progenitor
union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell
union_of: CL:0001028 ! CD7-positive lymphoid progenitor cell

[Term]
id: CL:0000996
name: mature CD11c-negative plasmacytoid dendritic cell
def: "Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell that has a high plasma membrane amount of CD80, CD86, and MHCII and has plasma membrane part CD83," [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486]
xref: DC_CL:0000009
is_a: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell

[Term]
id: CL:0000997
name: immature CD8_alpha-negative CD11b-positive dendritic cell
def: "Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that has a low plasma membrane amount of CD80, CD86, and MHCII." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000010
is_a: CL:0000999 ! CD8_alpha-negative CD11b-positive dendritic cell
relationship: develops_from CL:0001029 ! common dendritic progenitor

[Term]
id: CL:0000998
name: CD8_alpha-negative CD11b-negative dendritic cell
def: "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that lacks plasma membrane part CD11b, CD4 and CD8_alpha and has plasma membrane part CD205." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000011
is_a: CL:0000990 ! conventional dendritic cell

[Term]
id: CL:0000999
name: CD8_alpha-negative CD11b-positive dendritic cell
def: "CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that has plasma membrane part CD11b and CD4 and lacks plasma membrane part CD205 and CD8_alpha." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000012
is_a: CL:0000990 ! conventional dendritic cell

[Term]
id: CL:0001000
name: CD8_alpha-positive CD11b-negative dendritic cell
def: "CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that lacks plasma membrane part CD11b and CD4 and has plasma membrane part CD205 and CD8_alpha." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000013
is_a: CL:0000990 ! conventional dendritic cell

[Term]
id: CL:0001001
name: immature CD8_alpha-negative CD11b-negative dendritic cell
def: "Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that has a low plasma membrane amount of CD80, CD86, and MHCII." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000014
is_a: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell
relationship: develops_from CL:0001029 ! common dendritic progenitor

[Term]
id: CL:0001002
name: mature CD8_alpha-negative CD11b-negative dendritic cell
def: "Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that has a high plasma membrane amount of CD80, CD86, and MHCII and has plasma membrane part CD83." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000015
is_a: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell

[Term]
id: CL:0001003
name: mature CD8_alpha-negative CD11b-positive dendritic cell
def: "Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that has a high plasma membrane amount of CD80, CD86, and MHCII and has plasma membrane part CD83." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000016
is_a: CL:0000999 ! CD8_alpha-negative CD11b-positive dendritic cell

[Term]
id: CL:0001004
name: immature CD8_alpha-positive CD11b-negative dendritic cell
def: "Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that has a low plasma membrane amount of CD80, CD86, and MHCII." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000017
is_a: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell
relationship: develops_from CL:0001029 ! common dendritic progenitor

[Term]
id: CL:0001005
name: mature CD8_alpha-positive CD11b-negative dendritic cell
def: "Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that has a high plasma membrane amount of CD80, CD86, and MHCII and has plasma membrane part CD83." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000018
is_a: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell

[Term]
id: CL:0001006
name: dermal dendritic cell
def: "Dermal dendritic cell is a conventional dendritic cell that has plasma membrane part CD11b and CD205 and lacks plasma membrane part CD8_alpha." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000019
is_a: CL:0000990 ! conventional dendritic cell

[Term]
id: CL:0001007
name: interstitial dendritic cell
def: "Interstitial dendritic cell is a conventional dendritic cell that has plasma membrane part CD11b, CD1a, CD206, CD209, and CD36." [GO_REF:0000031, GOC:amm, PMID:17850486]
xref: DC_CL:0000020
is_a: CL:0000990 ! conventional dendritic cell

[Term]
id: CL:0001008
name: SCA1-positive hematopoietic stem cell
def: "SCA1-positive hematopoietic stem cell is a hematopoietic stem cell that has plasma membrane part CD117 and SCA1 and lacks plasma membrane part CD2, CD3, C34, CD4, CD45R, CD5, CD8, CD90,GR1, NK1.1, Ter-119." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047]
xref: DC_CL:0000043
is_a: CL:0000037 ! hematopoietic stem cell

[Term]
id: CL:0001009
name: immature dermal dendritic cell
def: "Immature dermal dendritic cell is a dermal dendritic cell that has a low plasma membrane amount of CD80, CD86, and MHCII." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000022
is_a: CL:0001006 ! dermal dendritic cell
relationship: develops_from CL:0001029 ! common dendritic progenitor

[Term]
id: CL:0001010
name: mature dermal dendritic cell
def: "Mature dermal dendritic cell is a dermal dendritic cell that has a high plasma membrane amount of CD80, CD86, and MHCII and has plasma membrane part CD83." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000023
is_a: CL:0001006 ! dermal dendritic cell

[Term]
id: CL:0001011
name: immature interstitial dendritic cell
def: "Immature interstitial dendritic cell is a interstitial dendritic cell that has a low plasma membrane amount of CD80, CD86, and MHCII." [GO_REF:0000031, GOC:amm, PMID:17850486]
xref: DC_CL:0000024
is_a: CL:0001007 ! interstitial dendritic cell
relationship: develops_from CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor

[Term]
id: CL:0001012
name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
xref: DC_CL:1110000
is_a: CL:0000837 ! hematopoietic progenitor cell
union_of: CL:0000557 ! granulocyte monocyte progenitor cell
union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell

[Term]
id: CL:0001013
name: mature interstitial dendritic cell
def: "Mature interstitial dendritic cell is a interstitial dendritic cell that has a high plasma membrane amount of CD80, CD86, and MHCII and has plasma membrane part CD83." [GO_REF:0000031, GOC:amm, PMID:17850486]
xref: DC_CL:0000025
is_a: CL:0001007 ! interstitial dendritic cell

[Term]
id: CL:0001014
name: CD1a-positive Langerhans cell
def: "CD1a-positive Langerhans cell is a Langerhans_cell that has plasma membrane part CD1a and CD324." [GO_REF:0000031, GOC:amm, PMID:17850486]
xref: DC_CL:0000026
is_a: CL:0000453 ! Langerhans cell

[Term]
id: CL:0001015
name: CD8_alpha-low Langerhans cell
def: "CD8_alpha-low Langerhans cell is a Langerhans cell that has a high plasma membrane amount of CD205 and has a low plasma membrane amount of CD8_alpha." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000027
is_a: CL:0000453 ! Langerhans cell

[Term]
id: CL:0001016
name: immature CD1a-positive Langerhans cell
def: "Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that has a low plasma membrane amount of CD80, CD86, and MHCII." [GO_REF:0000031, GOC:amm, PMID:17850486]
xref: DC_CL:0000028
is_a: CL:0001014 ! CD1a-positive Langerhans cell

[Term]
id: CL:0001017
name: mature CD1a-positive Langerhans cell
def: "Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that has a high plasma membrane amount of CD80, CD86, and MHCII and has plasma membrane part CD83." [GO_REF:0000031, GOC:amm, PMID:17850486]
xref: DC_CL:0000029
is_a: CL:0001014 ! CD1a-positive Langerhans cell

[Term]
id: CL:0001018
name: immature CD8_alpha-low Langerhans cell
def: "Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that has a low plasma membrane amount of CD80, CD86, and MHCII." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000030
is_a: CL:0001015 ! CD8_alpha-low Langerhans cell
relationship: develops_from CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor

[Term]
id: CL:0001019
name: CD115-positive monocyte OR common dendritic progenitor
xref: DC_CL:1111000
is_a: CL:0000837 ! hematopoietic progenitor cell
union_of: CL:0001022 ! CD115-positive monocyte
union_of: CL:0001029 ! common dendritic progenitor

[Term]
id: CL:0001020
name: mature CD8_alpha-low Langerhans cell
def: "Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that has a high plasma membrane amount of CD80, CD86, and MHCII and has plasma membrane part CD83." [GO_REF:0000031, GOC:amm, PMID:18082389]
xref: DC_CL:0000031
is_a: CL:0001015 ! CD8_alpha-low Langerhans cell

[Term]
id: CL:0001021
name: CD10-positive common lymphoid progenitor
def: "CD10-positive common lymphoid progenitor is a common lymphoid progenitor that has plasma membrane part CD10, CD45RA, and CD34 and lacks plasma membrane part CD19, CD3, and CD4." [GO_REF:0000031, GOC:add, GOC:amm, PMID:18082389]
synonym: "CD10-positive common lymphocyte precursor" EXACT []
synonym: "CD10-positive common lymphocyte progenitor" EXACT []
synonym: "CD10-positive common lymphoid precursor" EXACT []
xref: DC_CL:0000032
is_a: CL:0000051 ! common lymphoid progenitor
relationship: develops_from CL:0001024 ! CD133-positive hematopoietic stem cell

[Term]
id: CL:0001022
name: CD115-positive monocyte
def: "CD115-positive monocyte is a monocyte that has plasma membrane part CD115 and CD11b." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047]
xref: DC_CL:0000033
is_a: CL:0000576 ! monocyte
relationship: develops_from CL:0001023 ! CD117-positive common myeloid progenitor

[Term]
id: CL:0001023
name: CD117-positive common myeloid progenitor
def: "CD117-positive common myeloid progenitor is a common myeloid progenitor that has plasma membrane part CD117 and CD34 and lacks plasma membrane part CD2, CD217, CD3, CD4, CD45R, CD5, CD8, GR1, NK1.1, SCA1, and Ter-119." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047]
synonym: "CD117-positive common myeloid precursor" EXACT []
xref: DC_CL:0000034
is_a: CL:0000049 ! common myeloid progenitor
relationship: develops_from CL:0001008 ! SCA1-positive hematopoietic stem cell

[Term]
id: CL:0001024
name: CD133-positive hematopoietic stem cell
def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that has plasma membrane part CD133 and CD34 and lacks plasma membrane part CD11b, CD15, CD16, CD19, CD2, CD3, CD33, CD56, and CD71." [GO_REF:0000031, GOC:add, GOC:amm, PMID:16551251]
xref: DC_CL:0000035
is_a: CL:0000037 ! hematopoietic stem cell

[Term]
id: CL:0001025
name: CD217-positive common lymphoid progenitor
def: "CD217-positive common lymphoid progenitor is a common lymphoid progenitor that has plasma membrane part CD117, CD217, SCA1 and lacks plasma membrane part CD2, CD3, CD4, CD45R, CD5, GR1, CD8, NK1.1, Ter-119." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047]
synonym: "CD217-positive common lymphocyte precursor" EXACT []
synonym: "CD217-positive common lymphocyte progenitor" EXACT []
synonym: "CD217-positive common lymphoid precursor" EXACT []
xref: DC_CL:0000036
is_a: CL:0000051 ! common lymphoid progenitor
relationship: develops_from CL:0001008 ! SCA1-positive hematopoietic stem cell

[Term]
id: CL:0001026
name: CD71-positive common myeloid progenitor
def: "CD71-positive common myeloid progenitor is a common myeloid progenitor that has plasma membrane part CD34, CD45RA, and CD71 and lacks plasma membrane part CD10, CD19, CD3, CD4, and CD7." [GO_REF:0000031, GOC:add, GOC:amm, PMID:16551251]
synonym: "CD71-positive common myeloid precursor" EXACT []
xref: DC_CL:0000038
is_a: CL:0000049 ! common myeloid progenitor
relationship: develops_from CL:0001024 ! CD133-positive hematopoietic stem cell

[Term]
id: CL:0001027
name: CD7-negative lymphoid progenitor cell
def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that has plasma membrane part CD34 and lacks plasma membrane part CD19, CD3, CD4, CD45RA, and CD7." [GO_REF:0000031, GOC:amm, PMID:16551251]
synonym: "CD7-negative lymphoid precursor" EXACT []
xref: DC_CL:0000039
is_a: CL:0000838 ! lymphoid progenitor cell
relationship: develops_from CL:0001021 ! CD10-positive common lymphoid progenitor

[Term]
id: CL:0001028
name: CD7-positive lymphoid progenitor cell
def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that has plasma membrane part CD34 and CD7 and lacks plasma membrane part CD19, CD3, CD4, CD45RA." [GO_REF:0000031, GOC:amm, PMID:16551251]
synonym: "CD7-positive lymphoid precursor" EXACT []
xref: DC_CL:0000040
is_a: CL:0000838 ! lymphoid progenitor cell
relationship: develops_from CL:0001021 ! CD10-positive common lymphoid progenitor

[Term]
id: CL:0001029
name: common dendritic progenitor
def: "Common dendritic precursor is a hematopoietic progenitor cell that has plasma membrane part CD117, CD135, and M-CSFR." [GO_REF:0000031, GOC:amm, PMID:16551251]
xref: DC_CL:0000041
is_a: CL:0000837 ! hematopoietic progenitor cell
relationship: develops_from CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor

[Term]
id: CL:0001030
name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
xref: DC_CL:1111100
is_a: CL:0000837 ! hematopoietic progenitor cell
union_of: CL:0001023 ! CD117-positive common myeloid progenitor
union_of: CL:0001025 ! CD217-positive common lymphoid progenitor

[Term]
id: CL:0001031
name: cerebellar granule cell
def: "Granule cell that is part of the cerebellum." [GOC:mah]
is_a: CL:0000120 ! granule cell

[Term]
id: CL:0001032
name: cortical granule cell
def: "Granule cell that is part of the cerebral cortex." [GOC:mah]
is_a: CL:0000120 ! granule cell

[Term]
id: CL:0001033
name: hippocampal granule cell
def: "Granule cell that is part of the hippocampus." [GOC:mah]
is_a: CL:0000120 ! granule cell

[Term]
id: CL:0001658
name: visual pigment cell (sensu Nematoda and Protostomia)
xref: FBbt:00004230
is_a: CL:0000149 ! visual pigment cell
is_a: CL:0000341 ! pigment cell (sensu Nematoda and Protostomia)

[Term]
id: CL:0005000
name: spinal cord interneuron
def: "A CNS interneuron located in the spinal cord." [CL:CVS]
comment: Is_a interneuron, part_of UBERON:0002240.
is_a: CL:0000402 ! CNS interneuron

[Term]
id: CL:0005001
name: iridoblast
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an iridophore." [CL:CVS]
comment: Derived from UBERON:0002342 neural crest.
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0005002
name: xanthoblast
def: "A non-terminally differentiated cell that differentiates into a xanthophore." [CL:CVS]
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0005003
name: leucoblast
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a leucophore." [CL:CVS]
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0005004
name: pigment erythroblast
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into an erythrophore." [CL:CVS]
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0005005
name: cyanoblast
def: "A non-terminally differentiated cell that originates from the neural crest and differentiates into a cyanophore." [CL:CVS]
is_a: CL:0000055 ! non-terminally differentiated cell
relationship: develops_from CL:0000333 ! neural crest cell

[Term]
id: CL:0005006
name: ionocyte
def: "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment." [PMID:17555741, PMID:19268451]
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0005007
name: Kolmer-Agduhr neuron
def: "Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons." [PMID:18680739]
synonym: "KA cell" EXACT []
synonym: "KA interneuron" EXACT [PMID:15539490]
synonym: "KA neuron" EXACT [PMID:9634146]
synonym: "Kolmer-Agduhr cell" EXACT []
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:0005000 ! spinal cord interneuron

[Term]
id: CL:0005008
name: macular hair cell
def: "An auditory hair cell located in the macula that is sensitive to auditory stimuli." [CL:CVS]
is_a: CL:0000202 ! auditory hair cell

[Term]
id: CL:0005009
name: renal principal cell
def: "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the cells apical membrane is regulated by aldosterone and vasopressin. In mammals these cells are located in the renal collecting ducts." [CL:CVS]
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0005010
name: renal intercalated cell
def: "A cuboidal epithelial cell of the kidney that regulates acid/base balance." [CL:CVS]
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:0005011
name: renal alpha-intercalated cell
def: "A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance." [CL:CVS]
is_a: CL:0005010 ! renal intercalated cell

[Term]
id: CL:0005012
name: multi-ciliated epithelial cell
def: "A ciliated epithelial cell with many cilium." [CL:CVS]
is_a: CL:0000067 ! ciliated epithelial cell

[Term]
id: CL:0005013
name: single ciliated epithelial cell
def: "A ciliated epithelial cell with a single cilium." [CL:CVS]
is_a: CL:0000067 ! ciliated epithelial cell

[Term]
id: CL:0005014
name: auditory epithelial support cell
def: "A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells." [CL:CVS]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000630 ! supportive cell

[Term]
id: CL:0005015
name: inner phalangeal cell
def: "An auditory epithelial support cell that surrounds the nerve fibers and synapses of the auditory inner hair cells." [CL:CVS]
is_a: CL:0005014 ! auditory epithelial support cell

[Term]
id: CL:0005016
name: apical cell
def: "The apical cell is the upper cell formed after the first division of a plant zygote." [TAIR:TB]
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0005017
name: plant basal cell
def: "The lower cell formed after the first division of a plant zygote." [TAIR:TB]
is_a: CL:0000610 ! plant cell

[Term]
id: CL:0005018
name: ghrelin secreting cell
def: "A cell that secretes ghrelin, the peptide hormone that stimulates hunger." [CL:curator]
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0005019
name: pancreatic epsilon cell
def: "Ghrelin secreting cells found in the endocrine pancreas." [PMID:14970313]
comment: In mammals the endocrine pancreas is call the Islets of Langerhans.
is_a: CL:0005018 ! ghrelin secreting cell

[Term]
id: CL:1000036
name: hepatic oval cell
is_a: CL:0000036 ! epithelial fate stem cell

[Term]
id: CL:1000082
name: stretch receptor cell
is_a: CL:0000006 ! receptor cell (sensu Animalia)

[Term]
id: CL:1000083
name: stratified keratinized epithelial stem cell
is_a: CL:0000357 ! stratified epithelial stem cell

[Term]
id: CL:1000085
name: stratified non keratinized epithelial stem cell
is_a: CL:0000357 ! stratified epithelial stem cell

[Term]
id: CL:1000191
name: pillar cell
def: "A cell that lines the tunnel of Corti in the mammalian cochlea. The tunnel of Corti lies between the single row of inner hair cells and the first row of outer hair cells." [PMID:12417662]
synonym: "cochlear pillar cell" RELATED []
synonym: "pillar cell of cochlea" EXACT []
xref: FMA:75722
is_a: CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: CL:1000274
name: trophectodermal cell
synonym: "trophectoderm cell" EXACT []
is_a: CL:0000349 ! extraembryonic cell

[Typedef]
id: develops_from
name: develops_from
is_transitive: true

