Utility              package:qtlDesign              R Documentation

_U_t_i_l_i_t_y _f_u_n_c_t_i_o_n_s

_D_e_s_c_r_i_p_t_i_o_n:

     Utility functions

_U_s_a_g_e:

     recomb(d)
     genetic.dist(theta)
     pmixnorm(x,mean=c(0,0),sd=c(1,1),mix.prop=0.5,level=0)
     prop2delta.bc(prop)
     delta2prop.bc(delta)
     prop2delta.f2(prop,model)
     delta2prop.f2(delta,model)
     prop2gv(prop)
     gv2prop(gv)

_A_r_g_u_m_e_n_t_s:

       d: Genetic distance in Morgans

   theta: Recombination fraction

       x: Real number

    mean: Means of component mixtures

      sd: Standard deviations of component mixtures

mix.prop: Mixing proportion

   level: Subtracting constant

    prop: Proportion of variance explained by a QTL

   delta: QTL effect size

   model: Type of genetic model

      gv: Genetic variance

_D_e_t_a_i_l_s:

_V_a_l_u_e:

     'recomb' returns the recombination fraction corresponding to a
     genetic distance in Morgans.  'genetic.dist' returns the genetic
     distance in Morgans for a recombination fraction. 'pmixnorm'
     returns the probability mixture of two Normal distributions with
     means given by 'mean', standard deviations 'sd', and mixing
     proportions 'mix.prob', is less than 'x'. 'prop2delta.bc' returns
     the QTL effect from the proportion of variance explained for a
     backcross. 'delta2prop.bc' returns the QTL effect from the
     proportion of variance explained in a backcross. 'prop2delta.f2'
     returns the QTL effect from the proportion of variance explained
     and genetic model for a F2 intercross. 'delta2prop.f2' returns the
     QTL effect from the proportion of variance explained and the
     genetic model in an F2 intercross. 'prop2gv' returns the genetic
     variance (as a fraction of the environmental variance) given the
     proportion of variance explained by a QTL. 'gv2prop' performs the
     inverse function.

_N_o_t_e:

     We assume Haldane mapping function for the genetic distance.

_A_u_t_h_o_r(_s):

     Saunak Sen, Jaya Satagopan, and Gary Churchill

_R_e_f_e_r_e_n_c_e_s:

     Sen, Satagopan, and Churchill (2004), QTL study design from an
     information perspective, <URL:
     http://repositories.cdlib.org/cbmb/QTLdesign>.

_S_e_e _A_l_s_o:

     'missinfo'

_E_x_a_m_p_l_e_s:

     recomb(0.1)
     genetic.dist(0.1)
     prop2delta.bc(0.1)
     delta2prop.bc(0.1)

